119,508 research outputs found

    Keterampilan Manajerial Kepala Sekolah

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    The general purpose of this study was to determine the skills of junior High School number 7 Lubuklinggau. While the specific purpose of this research are: (1) to describe the conceptual skills of Principal. (2) to describe human relations skills of Principal. (3) to describe the technical skills of Principal. This research used descriptive qualitative method is based on the formulation of research that requires researchers to explore in order to understand and explain the problems examined through an intensive relationship with the source data. In General researcherscan deduce that the Principal of the junior high school number 7 Lubuklinggau.Keywod: managerial skills, principa

    ANALISIS PELAYANAN DINAS DUKCAPIL KOTA CIMAHI DI ERA PANDEMI COVID 19

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    Penelitian ini bertujuan untuk mengetahui dan melakukan analisis terhadap pelayanan yang dilakukan oleh Dinas DUKCAPIL Kota Cimahi di masa pandemic covid 19, DUKCAPIL kota Cimahi adalah salah satu dinas yang memiliki tugas pokok dan fungsi untuk dapat melayani masyarakat terkait dengan dokumen kependudukan dan pencatatan sipil. Peneltian mengunakan metode kualitatif deskriptif dengan pendekatan induktif, penelitian dilakukan dengan observasi secara langsung dan merilis data-data terkait pelayanan yang dilakukan oleh dinas DUKCAPIL kota Cimahi. Yang dirilis oleh Dinas Penerangan Kota Cimahi. Simpulan yang didapat, bahwa dengan pandemic covid 19, kota Cimahi melakukan PPKM, yaitu penetapan pembatasan kegiatan masyarakat, dimana pelayanan dilakukan sebahagian besar dengan system daring(on-line), dan hanya dinas-dinas tertentu yang melakukan pelayanan secara langsung, seperti dinas kebersihan, dinas perhubungan, dan dinas Satpol PP. sehingga pelayanan dinas DUKCAPIL sangat dirasakan belum optimal, diperlukan adanya sinergitas dari Dinas-dinas yang melakukan pelayanan kepada masyarakat di kota Cimahi.Kata Kunci: Analisis, Pelayanan public, pandemic covid 1

    Dopamine perturbation of gene co-expression networks reveals differential response in schizophrenia for translational machinery.

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    The dopaminergic hypothesis of schizophrenia (SZ) postulates that positive symptoms of SZ, in particular psychosis, are due to disturbed neurotransmission via the dopamine (DA) receptor D2 (DRD2). However, DA is a reactive molecule that yields various oxidative species, and thus has important non-receptor-mediated effects, with empirical evidence of cellular toxicity and neurodegeneration. Here we examine non-receptor-mediated effects of DA on gene co-expression networks and its potential role in SZ pathology. Transcriptomic profiles were measured by RNA-seq in B-cell transformed lymphoblastoid cell lines from 514 SZ cases and 690 controls, both before and after exposure to DA ex vivo (100 μM). Gene co-expression modules were identified using Weighted Gene Co-expression Network Analysis for both baseline and DA-stimulated conditions, with each module characterized for biological function and tested for association with SZ status and SNPs from a genome-wide panel. We identified seven co-expression modules under baseline, of which six were preserved in DA-stimulated data. One module shows significantly increased association with SZ after DA perturbation (baseline: P = 0.023; DA-stimulated: P = 7.8 × 10-5; ΔAIC = -10.5) and is highly enriched for genes related to ribosomal proteins and translation (FDR = 4 × 10-141), mitochondrial oxidative phosphorylation, and neurodegeneration. SNP association testing revealed tentative QTLs underlying module co-expression, notably at FASTKD2 (top P = 2.8 × 10-6), a gene involved in mitochondrial translation. These results substantiate the role of translational machinery in SZ pathogenesis, providing insights into a possible dopaminergic mechanism disrupting mitochondrial function, and demonstrates the utility of disease-relevant functional perturbation in the study of complex genetic etiologies

    Condensation of MgS in outflows from carbon stars

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    The basic mechanism responsible for the widespread condensation of MgS in the outflows from carbon rich stars on the tip of the AGB is discussed with the aim of developing a condensation model that can be applied in model calculations of dust formation in stellar winds. The different possibilities how MgS may be formed in the chemical environment of outflows from carbon stars are explored by some thermochemical calculations and by a detailed analysis of the growth kinetics of grains in stellar winds. The optical properties of core-mantle grains with a MgS mantle are calculated to demonstrate that such grains reproduce the structure of the observed 30 μ\mum feature. These considerations are complemented by model calculations of circumstellar dust shells around carbon stars. It is argued that MgS is formed via precipitation on silicon carbide grains. This formation mechanism explains some of the basic observed features of MgS condensation in dust shells around carbon stars. A weak secondary peak at about 33 ... 36 μ\mum is shown to exist in certain cases if MgS forms a coating on SiC.Comment: 9 pages, 7 figure

    The relationship between price volatility, maturity and volume of trade of the Malaysian bond market

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    Kajian ini cuba membuat eksplorasi ke atas kesan tempoh matang dan volum dagangan ke atas kemeruapan pasaran bon Malaysia. Bon MGS, Cagamas clan Korporat yang aktif didagangkan merupakan data yang digunakan di dalam kajian ini. Perhubungan di antara pembolehubah-pembolehubah ini seterusnya dicerap dengan menggunakan analisa regresi. Tempoh kajian ini dibahagikan kepada tiga tempoh iaitu tempoh krisis (Mac 1996-Jun I997), tempoh semasa krisis sebelum pegging (Julai 1997-Ogos 1998) dan tempoh krisis selepas pegging (September 1998-Mac 1999). Adalah didapati bahawa tidak wujud perhubungan di antara kemeruapan harga dan tempoh matang bagi bon MGS dan Cagamas tetapi bagi bon Korporat, perhubungan di antara pemboleh ubah tersebut adalah positif dalam semua tempoh masa. Keputusan kajian juga menunjukkan bagi bon Korporat apabila volum dagangan dimasukkan ke dalam persamaan regresi, perhubungan di antara tempoh matang dan kemeruapan harganya menjadi tidak signifikan kecuali bagi tempoh semasa krisis sebelum pegging
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