Is lymphoma curable?

This is early 1980s, a few years after I took up a consultant surgical pathologist post at the Royal Hampshire County Hospital in Winchester. I get a call from Dr Anthony Galea- Debono who is now a physician and neurologist in private practice in Malta. In the late 1970s, Tony and I used to meet often over lunch because we worked not far from each other in London, him at Queen’s Square and I at The Middlesex in Mortimer Street. The call from Galea-Debono is about a young woman in her early thirties who has been referred to him for management of a diagnosis of tuberculosis following an excision biopsy of an enlarged neck lymph node, and wishes the histology reviewed before he starts anti-tuberculous therapy. The lymph node histology, in fact, shows what I thought was a high grade large cell lymphoma with necrosis, the latter feature having been misinterpreted as tuberculous necrosis. The patient also complained of retrosternal pain on ingesting alcohol. I confirm the lymphoma diagnosis with Professor Dennis Wright, at the time a world figure in lymphoid pathology, and conveniently located in Southampton, just down the road from Winchester.peer-reviewe

Metric and topo-geometric properties of urban street networks: some convergences, divergences, and new results

The theory of cities, which has grown out of the use of space syntax techniques in urban studies, proposes a curious mathematical duality: that urban space is locally metric but globally topo-geometric. Evidence for local metricity comes from such generic phenomena as grid intensification to reduce mean trip lengths in live centres, the fall of movement from attractors with metric distance, and the commonly observed decay of shopping with metric distance from an intersection. Evidence for global topo-geometry come from the fact that we need to utilise both the geometry and connectedness of the larger scale space network to arrive at configurational measures which optimally approximate movement patterns in the urban network. It might be conjectured that there is some threshold above which human being use some geometrical and topological representation of the urban grid rather than the sense of bodily distance to making movement decisions, but this is unknown. The discarding of metric properties in the large scale urban grid has, however, been controversial. Here we cast a new light on this duality. We show first some phenomena in which metric and topo-geometric measures of urban space converge and diverge, and in doing so clarify the relation between the metric and topo-geometric properties of urban spatial networks. We then show how metric measures can be used to create a new urban phenomenon: the partitioning of the background network of urban space into a network of semi-discrete patches by applying metric universal distance measures at different metric radii, suggesting a natural spatial area-isation of the city at all scales. On this basis we suggest a key clarification of the generic structure of cities: that metric universal distance captures exactly the formally and functionally local patchwork properties of the network, most notably the spatial differentiation of areas, while the top-geometric measures identifying the structure which overcomes locality and links the urban patchwork into a whole at different scales

Metric and topo-geometric properties of urban street networks: some convergences, divergences and new results

The theory of cities, which has grown out of the use of space syntax techniques in urban studies, proposes a curious mathematical duality: that urban space is locally metric but globally topo-geometric. Evidence for local metricity comes from such generic phenomena as grid intensification to reduce mean trip lengths in live centres, the fall of movement from attractors with metric distance, and the commonly observed decay of shopping with metric distance from an intersection. Evidence for global topo-geometry come from the fact that we need to utilise both the geometry and connectedness of the larger scale space network to arrive at configurational measures which optimally approximate movement patterns in the urban network. It might be conjectured that there is some threshold above which human being use some geometrical and topological representation of the urban grid rather than the sense of bodily distance to making movement decisions, but this is unknown. The discarding of metric properties in the large scale urban grid has, however, been controversial. Here we cast a new light on this duality. We show first some phenomena in which metric and topo-geometric measures of urban space converge and diverge, and in doing so clarify the relation between the metric and topo-geometric properties of urban spatial networks. We then show how metric measures can be used to create a new urban phenomenon: the partitioning of the background network of urban space into a network of semi-discrete patches by applying metric universal distance measures at different metric radii, suggesting a natural spatial area-isation of the city at all scales. On this basis we suggest a key clarification of the generic structure of cities: that metric universal distance captures exactly the formally and functionally local patchwork properties of the network, most notably the spatial differentiation of areas, while the top-geometric measures identifying the structure which overcomes locality and links the urban patchwork into a whole at different scales

Network geography: relations, interactions, scaling and spatial processes in GIS

This chapter argues that the representational basis of GIS largely avoidseven the most rudimentary distortions of Euclidean space as reflected, forexample, in the notion of the network. Processes acting on networks whichinvolve both short and longer term dynamics are often absent from GIscience. However a sea change is taking place in the way we view thegeography of natural and man-made systems. This is emphasising theirdynamics and the way they evolve from the bottom up, with networks anessential constituent of this decentralized paradigm. Here we will sketchthese developments, showing how ideas about graphs in terms of the waythey evolve as connected, self-organised structures reflected in theirscaling, are generating new and important views of geographical space.We argue that GI science must respond to such developments and needs tofind new forms of representation which enable both theory andapplications through software to be extended to embrace this new scienceof networks

Residue symbols and Jantzen-Seitz partitions

Jantzen-Seitz partitions are those $p$-regular partitions of~$n$ which label $p$-modular irreducible representations of the symmetric group $S_n$ which remain irreducible when restricted to $S_{n-1}$; they have recently also been found to be important for certain exactly solvable models in statistical mechanics. In this article we study their combinatorial properties via a detailed analysis of their residue symbols; in particular the $p$-cores of Jantzen-Seitz partitions are determined

Flexible Learning Spaces Evaluation Report

City University, London is tackling the challenge of ensuring the learning spaces provided are able to meet the anticipated increase in technology usage and prevalent pedagogies. There is no longer a standard classroom design that will achieve this goal and therefore it is imperative to pilot and explore a variety of flexible learning spaces. This report feeds back on an evaluation of two flexible learning space approaches piloted in the autumn term of 2012 as alternatives to traditional computer rooms laid out in rows with the lecturer positioned at the front. These approaches are: pop-up computers on circular tables in AG24A; and laptop lockers enabling staff to borrow laptops to use with students on node chairs in AG24B. Each of these approaches also supported the use of students’ own devices in learning spaces. These methods were evaluated using surveys, interviews and an open house forum. The report shares the findings and recommendations from this evaluation and future plans for learning spaces

How do I enhance motivation to learn and higher order cognition among students of Science through the use of a virtual learning environment?

In this paper I explore the capacity of Moodle to enhance the teaching and learning of Leaving Certificate Biology within a small urban secondary school. I simultaneously investigate the potential of the technology to enhance higher-order cognition and motivation to learn among the students. Adopting an action research approach has led me to a much deeper understanding of the tacit knowledge that inspires my work. The chief stimulus to my research was the realisation that my explicit practice was in negation of my implicit values. I have come to know my practice and over time changed it. I can now see evidence of a greater congruence between my espoused core educational values and my explicit actions. Cycle one of the research focuses on setting up and introducing Moodle to a group of Biology students. The second cycle shows the feasibility of a community of enquiry through a discussion-forum. A process of social validation runs concurrently, in which interested individuals substantiate my claim that my core educational values are being translated into my practice. Throughout I learn to strike a balance between co-learner and guide. Consequently the students come to act as co-authors in moving away from authoritarian dissemination of facts. This facilitates a community of inquiry, revolving around the collaborative negotiation of meaning. There is clear evidence of increased higher-order cognition and motivation to learn among the participants within this virtual community

Anatomic-electrophysiological correlations concerning the pathways for atrioventricular conduction.

The remarkable success of radiofrequency ablation in recent decades in curing atrioventricular nodal reentrant tachycardias has intensified efforts to provide a solid theoretical basis for understanding the mechanisms of atrioventricular transmission. These efforts, which were made by both anatomists and electrophysiologists, frequently resulted in seemingly controversial observations. Quantitatively and qualitatively, our understanding of the mysteries of propagation through the inhomogeneous and extremely complex atrioventricular conduction axis is much deeper than it was at the beginning of the past century. We must go back to the initial sources, nonetheless, in an attempt to provide a common ground for evaluating the morphological and electrophysiological principles of junctional arrhythmias. In this review, we provide an account of the initial descriptions, which still provide an appropriate foundation for interpreting recent electrophysiological findings