Convolutional Sparse Kernel Network for Unsupervised Medical Image Analysis

The availability of large-scale annotated image datasets and recent advances in supervised deep learning methods enable the end-to-end derivation of representative image features that can impact a variety of image analysis problems. Such supervised approaches, however, are difficult to implement in the medical domain where large volumes of labelled data are difficult to obtain due to the complexity of manual annotation and inter- and intra-observer variability in label assignment. We propose a new convolutional sparse kernel network (CSKN), which is a hierarchical unsupervised feature learning framework that addresses the challenge of learning representative visual features in medical image analysis domains where there is a lack of annotated training data. Our framework has three contributions: (i) We extend kernel learning to identify and represent invariant features across image sub-patches in an unsupervised manner. (ii) We initialise our kernel learning with a layer-wise pre-training scheme that leverages the sparsity inherent in medical images to extract initial discriminative features. (iii) We adapt a multi-scale spatial pyramid pooling (SPP) framework to capture subtle geometric differences between learned visual features. We evaluated our framework in medical image retrieval and classification on three public datasets. Our results show that our CSKN had better accuracy when compared to other conventional unsupervised methods and comparable accuracy to methods that used state-of-the-art supervised convolutional neural networks (CNNs). Our findings indicate that our unsupervised CSKN provides an opportunity to leverage unannotated big data in medical imaging repositories.Comment: Accepted by Medical Image Analysis (with a new title 'Convolutional Sparse Kernel Network for Unsupervised Medical Image Analysis'). The manuscript is available from following link (https://doi.org/10.1016/j.media.2019.06.005

Multi-scale Orderless Pooling of Deep Convolutional Activation Features

Deep convolutional neural networks (CNN) have shown their promise as a universal representation for recognition. However, global CNN activations lack geometric invariance, which limits their robustness for classification and matching of highly variable scenes. To improve the invariance of CNN activations without degrading their discriminative power, this paper presents a simple but effective scheme called multi-scale orderless pooling (MOP-CNN). This scheme extracts CNN activations for local patches at multiple scale levels, performs orderless VLAD pooling of these activations at each level separately, and concatenates the result. The resulting MOP-CNN representation can be used as a generic feature for either supervised or unsupervised recognition tasks, from image classification to instance-level retrieval; it consistently outperforms global CNN activations without requiring any joint training of prediction layers for a particular target dataset. In absolute terms, it achieves state-of-the-art results on the challenging SUN397 and MIT Indoor Scenes classification datasets, and competitive results on ILSVRC2012/2013 classification and INRIA Holidays retrieval datasets

Learning a Hierarchical Latent-Variable Model of 3D Shapes

We propose the Variational Shape Learner (VSL), a generative model that learns the underlying structure of voxelized 3D shapes in an unsupervised fashion. Through the use of skip-connections, our model can successfully learn and infer a latent, hierarchical representation of objects. Furthermore, realistic 3D objects can be easily generated by sampling the VSL's latent probabilistic manifold. We show that our generative model can be trained end-to-end from 2D images to perform single image 3D model retrieval. Experiments show, both quantitatively and qualitatively, the improved generalization of our proposed model over a range of tasks, performing better or comparable to various state-of-the-art alternatives.Comment: Accepted as oral presentation at International Conference on 3D Vision (3DV), 201