2,207 research outputs found
Finite-size and correlation-induced effects in Mean-field Dynamics
The brain's activity is characterized by the interaction of a very large
number of neurons that are strongly affected by noise. However, signals often
arise at macroscopic scales integrating the effect of many neurons into a
reliable pattern of activity. In order to study such large neuronal assemblies,
one is often led to derive mean-field limits summarizing the effect of the
interaction of a large number of neurons into an effective signal. Classical
mean-field approaches consider the evolution of a deterministic variable, the
mean activity, thus neglecting the stochastic nature of neural behavior. In
this article, we build upon two recent approaches that include correlations and
higher order moments in mean-field equations, and study how these stochastic
effects influence the solutions of the mean-field equations, both in the limit
of an infinite number of neurons and for large yet finite networks. We
introduce a new model, the infinite model, which arises from both equations by
a rescaling of the variables and, which is invertible for finite-size networks,
and hence, provides equivalent equations to those previously derived models.
The study of this model allows us to understand qualitative behavior of such
large-scale networks. We show that, though the solutions of the deterministic
mean-field equation constitute uncorrelated solutions of the new mean-field
equations, the stability properties of limit cycles are modified by the
presence of correlations, and additional non-trivial behaviors including
periodic orbits appear when there were none in the mean field. The origin of
all these behaviors is then explored in finite-size networks where interesting
mesoscopic scale effects appear. This study leads us to show that the
infinite-size system appears as a singular limit of the network equations, and
for any finite network, the system will differ from the infinite system
Numerical analysis of a mechanotransduction dynamical model reveals homoclinic bifurcations of extracellular matrix mediated oscillations of the mesenchymal stem cell fate
We perform one and two-parameter numerical bifurcation analysis of a
mechanotransduction model approximating the dynamics of mesenchymal stem cell
differentiation into neurons, adipocytes, myocytes and osteoblasts. For our
analysis, we use as bifurcation parameters the stiffness of the extracellular
matrix and parameters linked with the positive feedback mechanisms that
up-regulate the production of the YAP/TAZ transcriptional regulators (TRs) and
the cell adhesion area. Our analysis reveals a rich nonlinear behaviour of the
cell differentiation including regimes of hysteresis and multistability, stable
oscillations of the effective adhesion area, the YAP/TAZ TRs and the
PPAR receptors associated with the adipogenic fate, as well as
homoclinic bifurcations that interrupt relatively high-amplitude oscillations
abruptly. The two-parameter bifurcation analysis of the Andronov-Hopf points
that give birth to the oscillating patterns predicts their existence for soft
extracellular substrates (), a regime that favours the neurogenic and
the adipogenic cell fate. Furthermore, in these regimes, the analysis reveals
the presence of homoclinic bifurcations that result in the sudden loss of the
stable oscillations of the cell-substrate adhesion towards weaker adhesion and
high expression levels of the gene encoding Tubulin beta-3 chain, thus
favouring the phase transition from the adipogenic to the neurogenic fate
Networks of coupled oscillators: From phase to amplitude chimeras
This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. This article appeared in Chaos 28, 113124 (2018) and may be found at https://doi.org/10.1063/1.5054181.We show that amplitude-mediated phase chimeras and amplitude chimeras can occur in the same network of nonlocally coupled identical oscillators. These are two different partial synchronization patterns, where spatially coherent domains coexist with incoherent domains and coherence/incoherence referring to both amplitude and phase or only the amplitude of the oscillators, respectively. By changing the coupling strength, the two types of chimera patterns can be induced. We find numerically that the amplitude chimeras are not short-living transients but can have a long lifetime. Also, we observe variants of the amplitude chimeras with quasiperiodic temporal oscillations. We provide a qualitative explanation of the observed phenomena in the light of symmetry breaking bifurcation scenarios. We believe that this study will shed light on the connection between two disparate chimera states having different symmetry-breaking properties.
Chimera states are emergent dynamical patterns in networks of coupled oscillators where coherent and incoherent domains coexist due to spontaneous symmetry-breaking. In oscillators that exhibit both phase and amplitude dynamics, two types of distinct chimera patterns exist, namely, amplitude-mediated phase chimeras (AMCs) and amplitude chimeras (ACs). In the AMC state coherent and incoherent regions are distinguished by different mean phase velocities: all coherent oscillators have the same phase velocity, however, the incoherent oscillators have disparate phase velocities. In contrast to AMC, in the AC state, all the oscillators have the same phase velocity, however, the oscillators in the incoherent domain show periodic oscillations with randomly shifted center of mass. Surprisingly, in all the previous studies on chimeras, a given network of continuous-time dynamical systems seems to show either AMC or AC: they never occur in the same network. In this paper, for the first time, we identify a network of coupled oscillators where both AMC and AC are observed in the same system, and we also provide a qualitative explanation of the observation based on symmetry-breaking bifurcations.DFG, 163436311, SFB 910: Kontrolle selbstorganisierender nichtlinearer Systeme: Theoretische Methoden und Anwendungskonzept
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