31,949 research outputs found
DISC: Deep Image Saliency Computing via Progressive Representation Learning
Salient object detection increasingly receives attention as an important
component or step in several pattern recognition and image processing tasks.
Although a variety of powerful saliency models have been intensively proposed,
they usually involve heavy feature (or model) engineering based on priors (or
assumptions) about the properties of objects and backgrounds. Inspired by the
effectiveness of recently developed feature learning, we provide a novel Deep
Image Saliency Computing (DISC) framework for fine-grained image saliency
computing. In particular, we model the image saliency from both the coarse- and
fine-level observations, and utilize the deep convolutional neural network
(CNN) to learn the saliency representation in a progressive manner.
Specifically, our saliency model is built upon two stacked CNNs. The first CNN
generates a coarse-level saliency map by taking the overall image as the input,
roughly identifying saliency regions in the global context. Furthermore, we
integrate superpixel-based local context information in the first CNN to refine
the coarse-level saliency map. Guided by the coarse saliency map, the second
CNN focuses on the local context to produce fine-grained and accurate saliency
map while preserving object details. For a testing image, the two CNNs
collaboratively conduct the saliency computing in one shot. Our DISC framework
is capable of uniformly highlighting the objects-of-interest from complex
background while preserving well object details. Extensive experiments on
several standard benchmarks suggest that DISC outperforms other
state-of-the-art methods and it also generalizes well across datasets without
additional training. The executable version of DISC is available online:
http://vision.sysu.edu.cn/projects/DISC.Comment: This manuscript is the accepted version for IEEE Transactions on
Neural Networks and Learning Systems (T-NNLS), 201
Statistical methods for tissue array images - algorithmic scoring and co-training
Recent advances in tissue microarray technology have allowed
immunohistochemistry to become a powerful medium-to-high throughput analysis
tool, particularly for the validation of diagnostic and prognostic biomarkers.
However, as study size grows, the manual evaluation of these assays becomes a
prohibitive limitation; it vastly reduces throughput and greatly increases
variability and expense. We propose an algorithm - Tissue Array Co-Occurrence
Matrix Analysis (TACOMA) - for quantifying cellular phenotypes based on
textural regularity summarized by local inter-pixel relationships. The
algorithm can be easily trained for any staining pattern, is absent of
sensitive tuning parameters and has the ability to report salient pixels in an
image that contribute to its score. Pathologists' input via informative
training patches is an important aspect of the algorithm that allows the
training for any specific marker or cell type. With co-training, the error rate
of TACOMA can be reduced substantially for a very small training sample (e.g.,
with size 30). We give theoretical insights into the success of co-training via
thinning of the feature set in a high-dimensional setting when there is
"sufficient" redundancy among the features. TACOMA is flexible, transparent and
provides a scoring process that can be evaluated with clarity and confidence.
In a study based on an estrogen receptor (ER) marker, we show that TACOMA is
comparable to, or outperforms, pathologists' performance in terms of accuracy
and repeatability.Comment: Published in at http://dx.doi.org/10.1214/12-AOAS543 the Annals of
Applied Statistics (http://www.imstat.org/aoas/) by the Institute of
Mathematical Statistics (http://www.imstat.org
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