The Influence of Lavender Aroma Therapy on Decreasing Blood Pressure in Hypertension Patients

The objective of this research was to determine the influence of lavender aromatherapy on decreasing blood pressure in hypertension patients. The research employed quantitative method with quasi experiment design. The samples were 32 patients either in the treatment group or in the non-treatment group. They were selected by consecutive sampling technique. The result of the research showed that the decrease in systolic and diastolic blood pressure of the treatment group was 9.7299 mmHg and 4.3237 mmHg while without treatment was 7.0461 mmHg and 3.51152 mmHg. Paired t-test resulted the probability value of systolic blood pressure was α (0.000) <0.05, the probability of diastolic blood pressure was α (0.000) <0.05. It could be concluded that there was the influence of lavender aromatherapy on the decrease in systolic and diastolic blood pressure. Inhalation with lavender aromatherapy method can become one of the considerations in nursing intervention to decrease blood pressure in hypertension patients. It can be an alternative of therapy complement besides medication

Lingnan Gardeners Newsletter (No. 35) = 嶺南彩園通訊 (第35期)

Lavender 薰衣草https://commons.ln.edu.hk/ln_gardeners_newsletter/1035/thumbnail.jp

Regulating Innovative Medicine: Fitting Square Pegs in Round Holes

Increasingly, innovative medical products are creating a quandary for the Food and Drug Administration ( FDA ) because they often transcend the FDA\u27s traditional categorical approach to regulating medical products. In a recent attempt to simplify this process, the FDA has proposed a new rule for regulating combination products. This iBrief discusses the FDA\u27s current approach and analyzes the possible affects of the proposed regulation. Because of the many shortcomings of both systems, this iBrief concludes that the FDA should instead stop assigning center jurisdiction based on a product\u27s primary mode of action, and give the Office of Combination Products internal agency jurisdiction over combination products. This alternative approach would increase consistency and efficiency while maintaining the FDA\u27s high standards for medical product safety and efficacy

Lavender oil-potent anxiolytic properties via modulating voltage dependent calcium channels

Recent clinical data support the clinical use of oral lavender oil in patients suffering from subsyndromal anxiety. We identified the molecular mechanism of action that will alter the perception of lavender oil as a nonspecific ingredient of aromatherapy to a potent anxiolytic inhibiting voltage dependent calcium channels (VOCCs) as highly selective drug target. In contrast to previous publications where exorbitant high concentrations were used, the effects of lavender oil in behavioral, biochemical, and electrophysiological experiments were investigated in physiological concentrations in the nanomolar range, which correlate to a single dosage of 80 mg/d in humans that was used in clinical trials. We show for the first time that lavender oil bears some similarities with the established anxiolytic pregabalin. Lavender oil inhibits VOCCs in synaptosomes, primary hippocampal neurons and stably overexpressing cell lines in the same range such as pregabalin. Interestingly, Silexan does not primarily bind to P/Q type calcium channels such as pregabalin and does not interact with the binding site of pregabalin, the α2δ subunit of VOCCs. Lavender oil reduces non-selectively the calcium influx through several different types of VOCCs such as the N-type, P/Q-type and T-type VOCCs. In the hippocampus, one brain region important for anxiety disorders, we show that inhibition by lavender oil is mainly mediated via N-type and P/Q-type VOCCs. Taken together, we provide a pharmacological and molecular rationale for the clinical use of the oral application of lavender oil in patients suffering from anxiety

Effectiveness of Indonesian Essential Oil Mixture of Lemongrass, Cananga, and Patchouli in Relaxation Through Inhalation: a Clinical Test on Healthy Woman with High Potential for Stress

Relaxation is one of many mechanisms for coping with stress. One of the most widely used methods for relaxation is aromatherapy with the application of essential oils. Known for their therapeutic benefits, essential oils can be extracted from various Indonesian native herbs such as lemongrass (sereh wangi or Cymbopogon winterianus), cananga or ylang-ylang (kenanga or Canarium odoratum), and patchouli (nilam or Pogostemon cabin). This study aims to examine the effectiveness of a mixture of Indonesian essential oil made of lemongrass, cananga, and patchouli extracts. Experiment was conducted by asking a number of subjects to inhale the oil mixture and assessing its effectiveness in terms of psychological relaxation by using Visual Analog Scale or VAS) and of physical relaxation by examining the subjects’ blood pressure (MAP), pulse frequency, and breathing frequency. The result was then compared with that of lavender oil and with the control group. The study was conducted on 60 healthy women through single-blind clinical trials (before and after) using the “intent to treat” approach, followed by a startle test. Participants were divided into three groups: (1) 20 participants who were treated with Indonesian essential oil mixture, (2) 20 participants who were treated with lavender oil, and (3) 20 participants who served as the control group. Psychological relaxation measurement showed that Indonesian essential oil mixture produced the same degree of effectiveness as lavender oil and the control groups did, although both treatments tended to produce better results than the control group did. However, physical relaxation measurement showed that Indonesian essential oil mixture produced a higher degree of effectiveness than lavender oil and tended to produce a better result than the control group did, especially in terms of blood pressure based on MAP scores.    &nbsp

Independent doubly truncated gamma variables

Density and distribution functions of the sum of independent variables, each having a truncated gamma density function, were derived for use in the measurement of complex physical phenomena

Pengaruh Aromaterapi Lavender Terhadap Intensitas Nyeri Pada Pasien Pasca Operasi Di Rumah Sakit Dustira Cimahi

Lavender as aromatherapy give effect of relaxing and sedation. Research aimed to know the influence of lavender aromatherapy on pain intensity on major surgical post operative patient. This research used pre-experimental design with one group pretest-posttest design form. Sample in this research as many as 10 people by purposive sampling technique and data analysis by paired t-test. Statistical test result obtained p value 0,001. There is seen a significance difference of pain intensity before and after lavender aromatherapy provision. Suggestion for Dustira Hospital Cimahi, research could become input for Hospital to applied lavender aromatherapy provision on post operative patient. Lavender aromatherapy should be taught before surgery, and patients can be applied in patients after surgery

The effects of aerobic exercise with lavender essence use on cognitive state and serum brain-derived neurotrophic factor levels in elderly with mild cognitive impairment

Introduction: The aim of this study was to investigate the effects of 12-week aerobic exercise and lavender essence on cognitive states and brain-derived neurotrophic factor (BDNF) levels of elderly with mild cognitive impairment (MCI).Methods: In this clinical study, 40 elderly whose scores for mini–mental state examination (MMSE) ranged 21 to 25 were purposively selected by simple sampling. They were randomly divided into 4 equal groups: aerobic exercise, lavender extract, aerobic-lavender. and placebo. They underwent their respective treatments for 12 weeks. The aerobic exercise consisted of 8-minute running session with intensity of 75-85 HRR Max for the first session. One minute was added to the running span after each 2 sessions. Accordingly, the running span reached 26 minutes at the end of the 12-week exercise period. To conduct treatment with lavender, 2 drops of lavender essence were administered twice a day. Before and after the treatments, cognitive state was measured and blood samples collected to measure BDNF.Results: BDNF levels of the exercise and exercise + lavender groups increased significantly compared to those of the other 2 groups (P < 0.05). In addition, the cognitive states of the 3 intervention groups increased significantly compared to that of the placebo group (P < 0.05).Conclusion: Combination of 12-week aerobic exercise and lavender may decelerate or probably halt the progressive process of the impairment via improving the cognitive state in elderly with MCI

Growth performance, in vitro antioxidant properties and chemical composition of the halophyte Limonium algarvense Erben are strongly influenced by the irrigation salinity

Limonium algarvense Erben (sea lavender) is a halophyte species with potential to provide natural ingredients with in vitro antioxidant, anti-inflammatory, neuroprotective and antidiabetic properties. This study reports for the first time the 1) cultivation of sea lavender in greenhouse conditions under irrigation with freshwater (approx. 0 mM NaCl) and saline aquaculture wastewater (300 and 600 mM NaCl), and 2) the influence of the irrigation salinity on the plant performance (e.g growth, number of produced leaves and flowers), in vitro antioxidant properties [radical scavenging activity (DPPH and ABTS), ferric reducing antioxidant power (FRAP), metal chelating properties on copper (CCA) and iron (ICA)], toxicity (in vitro on three mammalian cell lines) and chemical composition (determined by LC-ESI-HRMS/MS). The freshwater-irrigated plants had better growth performance than those irrigated with saltwater. Extracts from wild plants, had the highest antioxidant activity, but those from cultivated ones kept high in vitro antioxidant properties and interesting chemical profile. The flowers' extracts of plants irrigated with 300 mM NaCl had the highest antioxidant activities against DPPH, whereas those from freshwater-irrigated plants were more active on ABTS, CCA and FRAP. Most of the extracts showed nil toxicity. The flowers' extracts displayed the highest diversity of compounds, mainly quercetin, apigenin, luteolin, naringenin and their glycoside derivatives. Moreover, their abundance varied with the irrigation salinity. These data indicate that sea lavender plants can be successfully cultivated in greenhouse conditions under fresh- and saltwater irrigation, maintaining interesting biological and chemical properties.Funding Agency Portuguese Foundation for Science and Technology Portuguese National Budget CCMAR/Multi/04326/2019 GreenVet project ALG-01-0145-FEDER-028876 XtrerneAquaCrops FA-05-2017-028 Lisboa-01-0145-FEDER-022125-RNEM-IST ID/QUI/00100/201 Portuguese Foundation for Science and Technology SFRH/BD/116604/2016 CEECIND/00425/2017info:eu-repo/semantics/publishedVersio