InstructBio: A Large-scale Semi-supervised Learning Paradigm for Biochemical Problems

In the field of artificial intelligence for science, it is consistently an essential challenge to face a limited amount of labeled data for real-world problems. The prevailing approach is to pretrain a powerful task-agnostic model on a large unlabeled corpus but may struggle to transfer knowledge to downstream tasks. In this study, we propose InstructMol, a semi-supervised learning algorithm, to take better advantage of unlabeled examples. It introduces an instructor model to provide the confidence ratios as the measurement of pseudo-labels' reliability. These confidence scores then guide the target model to pay distinct attention to different data points, avoiding the over-reliance on labeled data and the negative influence of incorrect pseudo-annotations. Comprehensive experiments show that InstructBio substantially improves the generalization ability of molecular models, in not only molecular property predictions but also activity cliff estimations, demonstrating the superiority of the proposed method. Furthermore, our evidence indicates that InstructBio can be equipped with cutting-edge pretraining methods and used to establish large-scale and task-specific pseudo-labeled molecular datasets, which reduces the predictive errors and shortens the training process. Our work provides strong evidence that semi-supervised learning can be a promising tool to overcome the data scarcity limitation and advance molecular representation learning

Large-scale semi-supervised learning with online spectral graph sparsification

International audienceWe introduce Sparse-HFS, a scalable algorithm that can compute solutions to SSL problems using only O(n polylog(n)) space and O(m polylog(n)) time

BigSSL: Exploring the Frontier of Large-Scale Semi-Supervised Learning for Automatic Speech Recognition

We summarize the results of a host of efforts using giant automatic speech recognition (ASR) models pre-trained using large, diverse unlabeled datasets containing approximately a million hours of audio. We find that the combination of pre-training, self-training and scaling up model size greatly increases data efficiency, even for extremely large tasks with tens of thousands of hours of labeled data. In particular, on an ASR task with 34k hours of labeled data, by fine-tuning an 8 billion parameter pre-trained Conformer model we can match state-of-the-art (SoTA) performance with only 3% of the training data and significantly improve SoTA with the full training set. We also report on the universal benefits gained from using big pre-trained and self-trained models for a large set of downstream tasks that cover a wide range of speech domains and span multiple orders of magnitudes of dataset sizes, including obtaining SoTA performance on many public benchmarks. In addition, we utilize the learned representation of pre-trained networks to achieve SoTA results on non-ASR tasks.Comment: 14 pages, 7 figures, 13 tables; v2: minor corrections, reference baselines and bibliography updated; v3: corrections based on reviewer feedback, bibliography update

Distributed Low-rank Subspace Segmentation

Vision problems ranging from image clustering to motion segmentation to semi-supervised learning can naturally be framed as subspace segmentation problems, in which one aims to recover multiple low-dimensional subspaces from noisy and corrupted input data. Low-Rank Representation (LRR), a convex formulation of the subspace segmentation problem, is provably and empirically accurate on small problems but does not scale to the massive sizes of modern vision datasets. Moreover, past work aimed at scaling up low-rank matrix factorization is not applicable to LRR given its non-decomposable constraints. In this work, we propose a novel divide-and-conquer algorithm for large-scale subspace segmentation that can cope with LRR's non-decomposable constraints and maintains LRR's strong recovery guarantees. This has immediate implications for the scalability of subspace segmentation, which we demonstrate on a benchmark face recognition dataset and in simulations. We then introduce novel applications of LRR-based subspace segmentation to large-scale semi-supervised learning for multimedia event detection, concept detection, and image tagging. In each case, we obtain state-of-the-art results and order-of-magnitude speed ups

Lessons from Building Acoustic Models with a Million Hours of Speech

This is a report of our lessons learned building acoustic models from 1 Million hours of unlabeled speech, while labeled speech is restricted to 7,000 hours. We employ student/teacher training on unlabeled data, helping scale out target generation in comparison to confidence model based methods, which require a decoder and a confidence model. To optimize storage and to parallelize target generation, we store high valued logits from the teacher model. Introducing the notion of scheduled learning, we interleave learning on unlabeled and labeled data. To scale distributed training across a large number of GPUs, we use BMUF with 64 GPUs, while performing sequence training only on labeled data with gradient threshold compression SGD using 16 GPUs. Our experiments show that extremely large amounts of data are indeed useful; with little hyper-parameter tuning, we obtain relative WER improvements in the 10 to 20% range, with higher gains in noisier conditions.Comment: "Copyright 2019 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.