Промена на крвните лактати при ергометриско тестирање кај професионални фудбалери за време на една натпреварувачка полусезона

BACKGROUND: Determination of concentration of blood lactates on different degrees of ergometric loading in laboratory is of interest of monitoring of lactate tolerance and glycolysis adaptation as an important energy source during the football game. Blood lactates are often used as indicator of anaerobic energy production in football. In fact, they show the balance between lactate release and release, and as such to be a considered as an indicator several facts should be taken into account.AIM: The aim of this study is to determine the impact of individual phases of training process in the football on the blood lactates in professional football players, and to determine the differences in the concentration of blood lactates between individual phases of the training process.MATERIALS AND METHODS: This study was conducted at the PZU Kinetikus in Skopje during 2014 year. The study covers a sample of 36 respondents on age between 18 and 32 years, defined as professional football players from football club that is part of national premier football league. Concentration of blood lactates in mmol/l was determined, by using blood analyzer "ACCUSPORT", during the stationary phase, after completion of each level of the maximum load ergometric test and the recovery phase (3 minutes after test completion). – Lactates in stationary, lactates after 3 minutes, lactates after 6 minutes, lactates after 9 minutes, lactates after 12 minutes, lactates after 15 minutes, lactates after maximum and lactates after recovery.RESULTS: The blood lactate at maximum progressive growing ergometric test showed significant changes, at the fifth level of load (at the end of 15 minutes), at maximum load and at the stage of recovery, three minutes after the test.CONCLUSIONS: The significant reduction in blood lactate on the fifth level of the load, which is actually a level that is achieved AnT of 4 mmol/l, in the preparatory phase, may indicate preliminary signs of adaptation of glycolysis and lactate tolerance.ОСНОВА: Одредувањето на концентрацијата на крвните лактати на различни степени на ергометриско лабораториско оптоварување е од интерест за следење на лактатна толеранција и адаптацијата на гликолизата како важен енергетски извор во текот на фудбалската игра. Крвните лактати се често користен индикатор за анаеробната лактатна енергетска продукција во фудбалот. Всушност, тие го покажуваат балансот помеѓу создавањето, ослободувањето и отстранувањето на лактатите, и како такви, за да бидат индикатор, неколку факти треба да се земат предвид. ЦЕЛ: Целта ноа оваа студија е да се утврдивлијанието на одделните фази одтренажниот процес во фудбалот врз крвните лактати кај професионали фудбалери,како и да се утврдат разликите на концентрациите на крвните лактати помеѓу одделните фази на тренажниот процес. МАТЕРИЈАЛ И МЕТОДИ: Истражувањето е организирано од страна наПЗУ Кинетикус, Скопје во тек на 2014 година. Во студијата е опфатен примерок од 36 испитаници кои седефинирани како професионални фудбалери од еден фудбалски тим од Првата национална фудбалска лига на возраст од 18-32 години.Со помош на крвен анализатор "ACCUSPORT" одредена е концентрацијата на крвните лактати во ммол/л, во мирување, по завршување на секој степен на оптоварување на максималниот ергометриски тест и во фазата на опоравување (3 минути по завршување на тестот) -Лак мир, Лак 3мин, Лак 6мин, Лак 9мин, Лак 12мин, Лак 15 мин, Лак макс и Лак опор. РЕЗУЛТАТИ: Крвните лактати при максимален прогресивно растечки ергометриски тест покажаа значајни промени, и тоа, при петтиот степен на оптоварување (на крајот од 15-та минута), при максимално оптоварување и во фазата на опоравување, три минути по завршувањето на тестот. ЗАКЛУЧОЦИ: Значајното намалување на крвните лактати на петтиот степен на оптоварување, кој е всушност нивото на кое е постигнат AnT од 4 ммол/л, по подготвителната фаза, можеби индицира почетни знаци на адаптација на гликолизата и лактатната толеранциј

Point-of-care measurement of blood lactate in children admitted with febrile illness to an African District Hospital.

BACKGROUND: Lactic acidosis is a consistent predictor of mortality owing to severe infectious disease, but its detection in low-income settings is limited to the clinical sign of "deep breathing" because of the lack of accessible technology for its measurement. We evaluated the use of a point-of-care (POC) diagnostic device for blood lactate measurement to assess the severity of illness in children admitted to a district hospital in Tanzania. METHODS: Children between the ages of 2 months and 13 years with a history of fever were enrolled in the study during a period of 1 year. A full clinical history and examination were undertaken, and blood was collected for culture, microscopy, complete blood cell count, and POC measurement of blood lactate and glucose. RESULTS: The study included 3248 children, of whom 164 (5.0%) died; 45 (27.4%) of these had raised levels of blood lactate (>5 mmol/L) but no deep breathing. Compared with mortality in children with lactate levels of ≤ 3 mmol/L, the unadjusted odds of dying were 1.6 (95% confidence interval [CI].8-3.0), 3.4 (95% CI, 1.5-7.5), and 8.9 (95% CI, 4.7-16.8) in children with blood lactate levels of 3.1-5.0, 5.1-8.0, or >8.0 mmol/L, respectively. The prevalence of raised lactate levels (>5 mmol/L) was greater in children with malaria than in children with nonmalarial febrile illness (P < .001) although the associated mortality was greater in slide-negative children. CONCLUSIONS: POC lactate measurement can contribute to the assessment of children admitted to hospital with febrile illness and can also create an opportunity for more hospitals in resource-poor settings to participate in clinical trials of interventions to reduce mortality associated with hyperlactatemia

Robust Lasso-Zero for sparse corruption and model selection with missing covariates

We propose Robust Lasso-Zero, an extension of the Lasso-Zero methodology [Descloux and Sardy, 2018], initially introduced for sparse linear models, to the sparse corruptions problem. We give theoretical guarantees on the sign recovery of the parameters for a slightly simplified version of the estimator, called Thresholded Justice Pursuit. The use of Robust Lasso-Zero is showcased for variable selection with missing values in the covariates. In addition to not requiring the specification of a model for the covariates, nor estimating their covariance matrix or the noise variance, the method has the great advantage of handling missing not-at random values without specifying a parametric model. Numerical experiments and a medical application underline the relevance of Robust Lasso-Zero in such a context with few available competitors. The method is easy to use and implemented in the R library lass0

Increased tumor necrosis factor alpha and interleukin-6 serum levels and their correlation with laboratory parameters in patients with imported malaria

In malaria, blood concentrations of proinflammatory cytokines, such as tumor necrosis factor alpha (TNF-α) and interleukin (IL)-6, are increased. In a study which included 34 patients, TNF-α and IL-6 were examined in two phases, immediately after the admission of patients, and at the end of antimalarial therapy, when the parasitemia was negative. The results show a significant increase of TNF-α and IL-6 in the first phase, before the effects of antimalarial therapy. A very strong correlation between TNF-α and IL-6 is also confirmed, which suggests their coordinated production. Increased TNF-α values were correlated with an older age, the level of parasitemia, the number of platelets and leukocytes, elevated values of procalcitonin, D-dimer and lactate dehydrogenasе, and lower values of serum iron and antithrombin. Increased values of IL-6 were correlated with the level of parasitemia, the number of platelets and leukocytes, and elevated values of D-dimer and lactates

Modelling the microfiltration of lactic acid fermentation broths and comparison of operating modes

clarification of fermentation broths by cross-flow microfiltration. Microfiltration experiments conducted under constant transmembrane pressure and under constant permeate fluxes (higher and lower than the critical flux) were represented by the resistance in series model in which the membrane resistance, the adsorption resistance, the bacteria cake resistance and the soluble compounds concentration polarisation resistance were taken into account. The different operating modes were compared in terms of two industrial interest criteria: the productivity and fouling rates. Higher productivities were obtained during constant transmembrane pressure runs whereas the lowest fouling rate was observed during the run conducted with a constant permeate flux lower than the critical flux. However, this fouling was mainly due to adsorption and solute components concentration polarisation. Key words

Informetrics on accidents and trauma

MEDLINE database has been analysed for 1995-97 on index Accidents and Trauma. Publications output has been classified year-wise country-wise, journal-wise and other fine structure characteristics have been found. High frequency keywords have been identified. Other valuable data have been compiled. The value of informater for decision-making is brought out by this study and the comprehensive data compilation by MEDLINE is established

L'économie de mouvement en course à pied : comparaison entre mesures objectives et évaluations subjectives par l'entraineur spécialisé

L'économie de mouvement en course à pied est un paramètre essentiel pour la performance et de nouvelles méthodes d'entrainement essaient aujourd'hui de le cibler. La mesure de cette économie de course se fait habituellement en laboratoire par la consommation d'oxygène nécessaire au déplacement à une vitesse donnée sous-maximale. La question de cette étude est de voir dans quelle mesure l'oeil averti d'un entraineur en course à pied peut estimer l'économie de course, en comparaison à une mesure objective de la consommation d'oxygène. Au total, 22 coureurs de niveaux différents et 9 entraineurs ont pris part à cette étude. Elle s'est dans un premier temps déroulée avec les coureurs sur le site du Stade de Coubertin à Vidy (VD). Cette étape a permis les enregistrements vidéo et la mesure de leur économie de course respective ainsi que l'établissement des notes d'économies de référence. Dans un second temps, les évaluations par les entraineurs ont été faites en ligne sur la base des vidéos. Les résultats ont été traités de telle manière à obtenir des coefficients (corrélation intraclasse et kappa de Cohen) estimant la concordance des évaluations de chaque entraineur avec les notes de référence. La concordance au sein du groupe d'entraineurs a aussi été évaluée. L'étude présente en conclusion des résultats étonnants, remettant en question la capacité des entraineurs à évaluer l'économie de course de coureurs issus d'un groupe de performances hétérogènes par rapport à des mesures objectives. En revanche, l'étude présente des résultats indiquant une bonne concordance des entraineurs entre eux

LIVER TRANSPLANTATION FOR TYPE I GLYCOGEN STORAGE DISEASE

A 16½-year-old girl with type I glycogen storage disease was treated by orthotopic liver transplantation under cyclosporin/steroid immunosuppression. All metabolic stigmata of the disease were relieved and 1 year postoperatively she follows a normal diet and lifestyle

Impact of sorbic acid on germinant receptor-dependent and -independent germination pathways in Bacillus cereus

Amino acid- and inosine-induced germination of Bacillus cereus ATCC 14579 spores was reversibly inhibited in the presence of 3 mM undissociated sorbic acid. Exposure to high hydrostatic pressure, Ca-dipicolinic acid (DPA), and bryostatin, an activator of PrkC kinase, negated this inhibition, pointing to specific blockage of signal transduction in germinant receptor-mediated germination