Characterization of a monoclonal antibody that induces the acrosome reaction of sea urchin sperm.

A monoclonal antibody, J18/29, induces the acrosome reaction (AR) in spermatozoa of the sea urchin Strongylocentrotus purpuratus. J18/29 induces increases in both intracellular Ca2+ and intracellular pH similar to those occurring upon induction of the AR by the natural inducer, the fucose sulfate-rich glycoconjugate of egg jelly. Lowering the Ca2+ concentration or the pH of the seawater inhibits the J18/29-induced AR, as does treatment with Co2+, an inhibitor of Ca2+ channels. The J18/29-induced AR is also inhibited by verapamil, tetraethylammonium chloride, and elevated K+. All these treatments cause similar inhibition of the egg jelly-induced AR. J18/29 reacts with a group of membrane proteins ranging in molecular mass from 340 to 25 kD, as shown by immunoprecipitation of lysates of 125I-labeled sperm and Western blots. The most prominent reacting proteins are of molecular masses of 320, 240, 170, and 58 kD. The basis of the multiple reactivity appears to reside in the polypeptide chains of these proteins, as J18/29 binding is sensitive to protease digestion but resistant to periodate oxidation. There are approximately 570,000 sites per cell for J18/29 binding. J18/29 is the only reagent of known binding specificity that induces the AR; it identifies a subset of sperm membrane proteins whose individual characterization may lead to the isolation of the receptors involved in the triggering of the AR at fertilization

Coexistence of a triplet nodal order-parameter and a singlet order-parameter at the interfaces of ferromagnet-superconductor Co/CoO/In junctions

We present differential conductance measurements of Cobalt / Cobalt-Oxide / Indium planar junctions, 500nm x 500nm in size. The junctions span a wide range of barriers, from very low to a tunnel barrier. The characteristic conductance of all the junctions show a V-shape structure at low bias instead of the U-shape characteristic of a s-wave order parameter. The bias of the conductance peaks is, for all junctions, larger than the gap of indium. Both properties exclude pure s-wave pairing. The data is well fitted by a model that assumes the coexistence of s-wave singlet and equal spin p-wave triplet fluids. We find that the values of the s-wave and p-wave gaps follow the BCS temperature dependance and that the amplitude of the s-wave fluid increases with the barrier strength.Comment: 5 pages, Accepted to Phys. Rev.

Implications of a transition in the dark energy equation of state for the H0H_0 and σ8\sigma_8 tensions

We explore the implications of a rapid appearance of dark energy between the redshifts ($z$) of one and two on the expansion rate and growth of perturbations. Using both Gaussian process regression and a parameteric model, we show that this is the preferred solution to the current set of low-redshift ($z<3$) distance measurements if $H_0=73~\rm km\,s^{-1}\,Mpc^{-1}$ to within 1\% and the high-redshift expansion history is unchanged from the $\Lambda$CDM inference by the Planck satellite. Dark energy was effectively non-existent around $z=2$, but its density is close to the $\Lambda$CDM model value today, with an equation of state greater than $-1$ at $z<0.5$. If sources of clustering other than matter are negligible, we show that this expansion history leads to slower growth of perturbations at $z<1$, compared to $\Lambda$CDM, that is measurable by upcoming surveys and can alleviate the $\sigma_8$ tension between the Planck CMB temperature and low-redshift probes of the large-scale structure.Comment: 24 pages, 16 figure

Generic separating sets for 3D elasticity tensors

We define what is a generic separating set of invariant functions (a.k.a. a weak functional basis) for tensors. We produce then two generic separating sets of polynomial invariants for 3D elasticity tensors, one made of 19 polynomials and one made of 21 polynomials (but easier to compute) and a generic separating set of 18 rational invariants. As a byproduct, a new integrity basis for the fourth-order harmonic tensor is provided

Mars and frame-dragging: study for a dedicated mission

In this paper we preliminarily explore the possibility of designing a dedicated satellite-based mission to measure the general relativistic gravitomagnetic Lense-Thirring effect in the gravitational field of Mars. The focus is on the systematic error induced by the multipolar expansion of the areopotential and on possible strategies to reduce it. It turns out that the major sources of bias are the Mars'equatorial radius R and the even zonal harmonics J_L, L = 2,4,6... of the areopotential. An optimal solution, in principle, consists of using two probes at high-altitudes (a\approx 9500-9600 km) and different inclinations, and suitably combining their nodes in order to entirely cancel out the bias due to \delta R. The remaining uncancelled mismodelled terms due to \delta J_L, L = 2,4,6,... would induce a bias \lesssim 1%, according to the present-day MGS95J gravity model, over a wide range of admissible values of the inclinations. The Lense-Thirring out-of-plane shifts of the two probes would amount to about 10 cm yr^-1.Comment: LaTex2e, 16 pages, 5 figures, no tables. To appear in General Relativity and Gravitatio

The Foundation Supernova Survey: Measuring Cosmological Parameters with Supernovae from a Single Telescope

Measurements of the dark energy equation-of-state parameter, $w$, have been limited by uncertainty in the selection effects and photometric calibration of $z<0.1$ Type Ia supernovae (SNe Ia). The Foundation Supernova Survey is designed to lower these uncertainties by creating a new sample of $z<0.1$ SNe Ia observed on the Pan-STARRS system. Here, we combine the Foundation sample with SNe from the Pan-STARRS Medium Deep Survey and measure cosmological parameters with 1,338 SNe from a single telescope and a single, well-calibrated photometric system. For the first time, both the low-$z$ and high-$z$ data are predominantly discovered by surveys that do not target pre-selected galaxies, reducing selection bias uncertainties. The $z>0.1$ data include 875 SNe without spectroscopic classifications and we show that we can robustly marginalize over CC SN contamination. We measure Foundation Hubble residuals to be fainter than the pre-existing low-$z$ Hubble residuals by $0.046 \pm 0.027$ mag (stat+sys). By combining the SN Ia data with cosmic microwave background constraints, we find $w=-0.938 \pm 0.053$, consistent with $\Lambda$CDM. With 463 spectroscopically classified SNe Ia alone, we measure $w=-0.933\pm0.061$. Using the more homogeneous and better-characterized Foundation sample gives a 55% reduction in the systematic uncertainty attributed to SN Ia sample selection biases. Although use of just a single photometric system at low and high redshift increases the impact of photometric calibration uncertainties in this analysis, previous low-$z$ samples may have correlated calibration uncertainties that were neglected in past studies. The full Foundation sample will observe up to 800 SNe to anchor the LSST and WFIRST Hubble diagrams.Comment: 30 pages, 17 figures, accepted by Ap