Composite Patient Reports: A Laboratory Informatics Perspective and Pilot Project for Personalized Medicine and Translational Research

Clinical laboratories are a strong and integral partner in personalized health care. Laboratory information systems hold a vast amount of data representing human phenotypes, genotypes, biomarkers, progression of disease and response to therapy. These structured and unstructured free text data are critical for patient care and a resource for personalized medicine and translational research. Laboratory data are integrated into many electronic medical records that provide “summary reports” and “trending” to visualize longitudinal patient data. However, these generic reports are not sufficient to manage complex sub-specialty patients. There is an urgent need for end-user driven composite reports for the care of such patients. Using multiple myeloma as a model, this pilot was performed to assess the needs of stakeholders and create a customized report. This laboratory informatics solution is delivered at the point of care through the hospital EMR. Future work will involve further integration with hospital systems to promote clinical decision support and translational research

Interactive Visualization and Exploration of Time-oriented Clinical Data Using a Distributed Temporal-Abstraction Architecture

KNAVE-II is a system for visualization and exploration of large amounts of time-oriented clinical data and of multiple levels of clinically meaningful abstractions derivable from these data. KNAVE-II uses a distributed temporal-abstraction architecture that integrates a set of knowledge services, each interacting with a domain-specific knowledge source, a set of data-access services, each interacting with a clinical data source, and a computational service for deriving knowledge-based abstractions of the data