345 research outputs found

    Effects of municipal smoke-free ordinances on secondhand smoke exposure in the Republic of Korea

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    ObjectiveTo reduce premature deaths due to secondhand smoke (SHS) exposure among non-smokers, the Republic of Korea (ROK) adopted changes to the National Health Promotion Act, which allowed local governments to enact municipal ordinances to strengthen their authority to designate smoke-free areas and levy penalty fines. In this study, we examined national trends in SHS exposure after the introduction of these municipal ordinances at the city level in 2010.MethodsWe used interrupted time series analysis to assess whether the trends of SHS exposure in the workplace and at home, and the primary cigarette smoking rate changed following the policy adjustment in the national legislation in ROK. Population-standardized data for selected variables were retrieved from a nationally representative survey dataset and used to study the policy action’s effectiveness.ResultsFollowing the change in the legislation, SHS exposure in the workplace reversed course from an increasing (18% per year) trend prior to the introduction of these smoke-free ordinances to a decreasing (−10% per year) trend after adoption and enforcement of these laws (β2 = 0.18, p-value = 0.07; β3 = −0.10, p-value = 0.02). SHS exposure at home (β2 = 0.10, p-value = 0.09; β3 = −0.03, p-value = 0.14) and the primary cigarette smoking rate (β2 = 0.03, p-value = 0.10; β3 = 0.008, p-value = 0.15) showed no significant changes in the sampled period. Although analyses stratified by sex showed that the allowance of municipal ordinances resulted in reduced SHS exposure in the workplace for both males and females, they did not affect the primary cigarette smoking rate as much, especially among females.ConclusionStrengthening the role of local governments by giving them the authority to enact and enforce penalties on SHS exposure violation helped ROK to reduce SHS exposure in the workplace. However, smoking behaviors and related activities seemed to shift to less restrictive areas such as on the streets and in apartment hallways, negating some of the effects due to these ordinances. Future studies should investigate how smoke-free policies beyond public places can further reduce the SHS exposure in ROK

    Modern meat: the next generation of meat from cells

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    Modern Meat is the first textbook on cultivated meat, with contributions from over 100 experts within the cultivated meat community. The Sections of Modern Meat comprise 5 broad categories of cultivated meat: Context, Impact, Science, Society, and World. The 19 chapters of Modern Meat, spread across these 5 sections, provide detailed entries on cultivated meat. They extensively tour a range of topics including the impact of cultivated meat on humans and animals, the bioprocess of cultivated meat production, how cultivated meat may become a food option in Space and on Mars, and how cultivated meat may impact the economy, culture, and tradition of Asia

    Interrogating the interconnected biological networks in liver diseases reveals the core components of a perturbed homeostatic system.

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    This thesis explores the interplay between genetics, environment, and immunological regulation in metabolic associated fatty liver disease (MAFLD), metabolic steatohepatitis (MeSH), and hepatocellular carcinoma (HCC), focusing on liver response to dietary exposome and bone marrow hematopoietic stem and progenitor cells (HSPCs) activity. Using weighted gene co-expression network analysis (WGCNA), we assessed mRNA expression in murine models and human datasets, identifying conserved metabolic and immunological programs and discrepancies in immune responses. The heightened immune response in certain mouse models, reflective of bone marrow HSPCs response, is found protective and consistent with human data, emphasizing the crucial role of immune system-tumorigenesis interplay. Investigating regulatory factors, we spotlight bile acids’ significance. Maintaining a robust immune response is linked to reduced liver tumor burden, with HSPC dietary response as a potential regulatory factor. While cholesterol homeostasis disruptions alone don’t stimulate HSPCs, when combined with disrupted bile acid homeostasis, they significantly impact HSPCs. Rescuing bile acid synthesis dampens HSPC activity, underscoring bile acids' regulatory role. Our findings provide valuable insights into the intricate regulatory networks governing liver disease, presenting potential new avenues for research, including exploring bile acid metabolism’s direct regulation of bone marrow HSPCs, assessing the long-term impact of HSPC stimulation, and investigating liver cholesterol homeostasis’s effect on immunotherapy response. This research suggests exploration of minimal therapeutics targeting sensitive targets and context-driven interpretation in animal model extrapolation. Overall, our experimental approach shows potential in aiding the development of effective treatments for liver diseases, paving the way for future studies in this field

    Google search and the mediation of digital health information: a case study on unproven stem cell treatments

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    Google Search occupies a unique space within broader discussions of direct-to-consumer marketing of stem cell treatments in digital spaces. For patients, researchers, regulators, and the wider public, the search platform influences the who, what, where, and why of stem cell treatment information online. Ubiquitous and opaque, Google Search mediates which users are presented what types of content when these stakeholders engage in online searches around health information. The platform also sways the activities of content producers and the characteristics of the content they produce. For those seeking and studying information on digital health, this platform influence raises difficult questions around risk, authority, intervention, and oversight. This thesis addresses a critical gap in digital methodologies used in mapping and characterising that influence as part of wider debates around algorithmic accountability within STS and digital health scholarship. By adopting a novel methodological approach to Blackbox auditing and data collection, I provide a unique evidentiary base for the analysis of ads, organic results, and the platform mechanisms of influence on queries related to stem cell treatments. I explore the question: how does Google Search mediate information that people access online about ‘proven’ and ‘unproven’ stem cell treatments? Here I show that, in spite of a general ban on advertisements of stem cell treatments, users continue to be presented with content promoting unproven treatments. The types, frequency, and commercial intent of results related to stem cell treatments shifted across user groups including geography and, more troublingly, those impacted by Parkinson’s Disease and Multiple Sclerosis. Additionally, I find evidence that the technological structure of Google Search itself enables primary and secondary commercial activities around the mediation and dissemination of health information online. It suggests that Google Search’s algorithmically-mediated rendering of search results – including both commercial and non-commercial activities - has critical implications for the present and future of digital health studies

    GRS 2023 Program Booklet

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