325 research outputs found

    Artificial intelligence and computer-aided diagnosis in colonoscopy: current evidence and future directions

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    Computer-aided diagnosis offers a promising solution to reduce variation in colonoscopy performance. Pooled miss rates for polyps are as high as 22%, and associated interval colorectal cancers after colonoscopy are of concern. Optical biopsy, whereby in-vivo classification of polyps based on enhanced imaging replaces histopathology, has not been incorporated into routine practice because it is limited by interobserver variability and generally only meets accepted standards in expert settings. Real-time decision-support software has been developed to detect and characterise polyps, and also to offer feedback on the technical quality of inspection. Some of the current algorithms, particularly with recent advances in artificial intelligence techniques, match human expert performance for optical biopsy. In this Review, we summarise the evidence for clinical applications of computer-aided diagnosis and artificial intelligence in colonoscopy

    The role of artificial intelligence in prospective real-time histological prediction of colorectal lesions during colonoscopy: a systematic review and meta-analysis

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    Artificial intelligence (AI) presents a novel platform for improving disease diagnosis. However, the clinical utility of AI remains limited to discovery studies, with poor translation to clinical practice. Current data suggests that 26% of diminutive pre-malignant lesions and 3.5% of colorectal cancers are missed during colonoscopies. The primary aim of this study was to explore the role of artificial intelligence in real-time histological prediction of colorectal lesions during colonoscopy. A systematic search using MeSH headings relating to “AI”, “machine learning”, “computer-aided”, “colonoscopy”, and “colon/rectum/colorectal” identified 2290 studies. Thirteen studies reporting real-time analysis were included. A total of 2958 patients with 5908 colorectal lesions were included. A meta-analysis of six studies reporting sensitivities (95% CI) demonstrated that endoscopist diagnosis was superior to a computer-assisted detection platform, although no statistical significance was reached (p = 0.43). AI applications have shown encouraging results in differentiating neoplastic and non-neoplastic lesions using narrow-band imaging, white light imaging, and blue light imaging. Other modalities include autofluorescence imaging and elastic scattering microscopy. The current literature demonstrates that despite the promise of new endoscopic AI models, they remain inferior to expert endoscopist diagnosis. There is a need to focus developments on real-time histological predictions prior to clinical translation to demonstrate improved diagnostic capabilities and time efficiency

    Endoscopic Assessment and Treatment of Barrett’s Oesophagus

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    Oesophageal cancer worldwide is the eighth commonest cancer and carries a poor prognosis. Barrett’s oesophagus is the only known risk factor for oesophageal adenocarcinoma. Cancer progresses along a metaplasia-dysplasia pathway. Dysplastic changes may be seen on endoscopic assessment. This thesis presents evidence that i-Scan virtual chromoendoscopy together with acetic acid chromoendoscopy can improve dysplasia detection using a simple classification system. Superficial lesions, without deeper invasion (low and high grade dysplasia, early cancers) have a low risk of distant metastasis. Endoscopic resection and ablation techniques have been demonstrated to have an excellent efficacy and safety profile. The current standard of care for early Barrett’s neoplasia is endoscopic management rather than surgical intervention. Surgery for oesophageal cancer is centred in specialist units due to improved outcomes in high volume centres. The UK radiofrequency ablation registry collects outcomes for patients undergoing endoscopic therapy for Barrett’s neoplasia. This thesis demonstrates that there is no difference in dysplasia or intestinal metaplasia resolution rates or dysplasia recurrence between low and high volume centres. Learning curve analysis suggests that there is a change point at 18 cases, when the observed successful treatment rate of the centre becomes better than the expected rate. Centres should complete 20 cases before competency can be achieved. Treatment of Barrett’s neoplasia involves endoscopic resection of visible lesions. Due to the high risk of metachronous lesions, the remaining Barrett’s epithelium undergoes field ablation, commonly with radiofrequency ablation. Following successful treatment the risk of dysplasia recurrence is 6%. The risk increases with increasing length of the initial Barrett segment and with increasing age. The risk of untreated islands of Barrett’s IM is unknown but this thesis demonstrates that it does not seem to confer an increased risk of recurrence and may not require further ablation if unresponsive to treatment

    Improving the Management of Large Colorectal Polyps

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    This thesis is focused on identifying current practices in the management of large non pedunculated colorectal polyps (LNPCPs) and the development of a structured management framework to improve outcomes. The methodology used includes a systematic review to ascertain current knowledge and retrospective quantitative analysis to identify current LNPCP management outcomes. The English Bowel Cancer Screening Programme (BCSP) which has a high volume of recorded LNPCP data was used to facilitate the latter process. In addition, qualitative analysis using consensus methodology to create best practice guidelines, key performance indicators (KPIs) to audit LNPCP outcomes and a complex polyp multidisciplinary team process was undertaken. The main outcomes of this thesis were: 1. Confirmation of variation in LNPCP management practices leading to variable outcomes 2. Formulation of evidence based and expert consensus LNPCP management guidelines 3. Identification of KPIs to allow audit of LNPCP management and outcomes 4. Identification of pertinent research questions to improve evidence LNPCP base 5. Development and pilot of regional complex polyp multidisciplinary team meetin

    Narrow band imaging and serology in the assessment of premalignant gastric pathology

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    Background: Patient outcomes in gastric adenocarcinoma are poor due to late diagnosis. Detecting and treating at the premalignant stage has the potential to improve this. Helicobacter pylori is also a strong risk factor for this disease.Aims: Primary aims were to assess the diagnostic accuracy of magnified narrow band imaging (NBI-Z) endoscopy and serology in detecting normal mucosa, H. pylori gastritis and gastric atrophy. Secondary aims were to compare the diagnostic accuracies of two classification systems using both NBI-Z and white light endoscopy with magnification (WLE-Z) and evaluate the inter-observer agreement.Methods: Patients were prospectively recruited. Images of gastric mucosa were stored with histology and serum for IgG H. pylori and Pepsinogen (PG) I/II ELISAs. Blinded expert endoscopists agreed on mucosal pattern. Mucosal images and serological markers were compared with histology. Kappa statistics determined inter-observer variability for randomly allocated images among four experts and four non-experts.Results: 116 patients were prospectively recruited. Diagnostic accuracy of NBI-Z for determining normal gastric mucosa was 0.87(95%CI 0.82–0.92), H. pylori gastritis 0.65(95%CI 0.55–0.75) and gastric atrophy 0.88(95%CI 0.81–0.94). NBI-Z was superior to serology at detecting gastric atrophy: NBI-Z gastric atrophy 0.88(95%CI 0.81-0.94) vs PGI/II ratio

    Optimizing endoscopic strategies for colorectal cancer screening : improving colonoscopy effectiveness by optical, non-optical, and computer-based models

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    Introduction: Le cancer colorectal demeure un grave problème de santé publique au Canada. Les programmes de dépistage pourraient réduire l'incidence du cancer colorectal et la mortalité qui lui est associée. Une coloscopie de haute qualité est considérée comme un moyen rentable de prévenir le cancer en identifiant et en éliminant les lésions précurseurs du cancer. Bien que la coloscopie puisse servir de mesure préventive contre le cancer, la procédure peut imposer un fardeau supplémentaire à la santé publique par l'enlèvement et l'évaluation histologique de polypes colorectaux diminutifs et insignifiants, qui présentent un risque minime d'histologie avancée ou de cancer. La technologie de l'amélioration de l'image permettrait aux médecins de réséquer et de rejeter les polypes diminutifs ou de diagnostiquer et de laisser les polypes rectosigmoïdiens diminutifs sans examen histopathologique. Malgré la disponibilité de systèmes informatiques de caractérisation des polypes, la pratique du diagnostic optique reste limitée en raison de la crainte d'un mauvais diagnostic de cancer, d'une mauvaise surveillance des patients et des problèmes médico-légaux correspondants. Il est donc indispensable d'élaborer des stratégies alternatives de résection et d'élimination non optiques pour améliorer la précision et la sécurité du diagnostic optique et l'adapter à la pratique clinique. Ces stratégies doivent répondre à des critères cliniques simples et ne nécessitent pas de formation supplémentaire ni de dispositifs d'amélioration de l'image. De plus, la pratique sûre du diagnostic optique, la prise de décision appropriée concernant la technique de polypectomie ou l'intervalle de surveillance dépendent de l'estimation précise de la taille des polypes. La variabilité inter-endoscopistes dans la mesure de la taille des polypes exige le développement de méthodes fiables et validées pour augmenter la précision de la mesure de la taille. Une balance virtuelle intégrée à un endoscope haute définition est actuellement disponible pour le calcul automatique de la taille des polypes, mais sa faisabilité clinique n'a pas encore été établie. En dehors des points susmentionnés, une coloscopie de haute qualité nécessite l'examen complet de la muqueuse colique, ainsi que la visualisation de la valve iléocæcale et de l'orifice appendiculaire. À ce jour, aucune solution informatique n'a été capable d'assister les endoscopistes pendant les coloscopies en temps réel en détectant et en différenciant les points de repère cæcaux de façon automatique. Objectifs: Les objectifs de cette thèse sont : 1) d'étudier l'effet de la limitation du diagnostic optique aux polypes de 1 à 3 mm sur la sécurité du diagnostic optique pour le traitement des polypes diminutifs et l'acceptation par les endoscopistes de son utilisation dans les pratiques en temps réel tout en préservant ses potentiels de temps et de rentabilité ; 2) élaborer et examiner des stratégies non optiques de résection et d'élimination qui peuvent remplacer le diagnostic optique tout en offrant les mêmes possibilités d'économie de temps et d'argent ; 3) examiner la précision relative d'un endoscope à échelle virtuelle pour mesurer la taille des polypes ; 4) former, valider et tester un modèle d'intelligence artificielle qui peut prédire la complétude d'une procédure de coloscopie en identifiant les points de repère anatomiques du cæcum (c'est-à-dire la valve iléo-cæcale et l'orifice appendiculaire) et en les différenciant les uns des autres, des polypes et de la muqueuse normale. Méthodes: Pour atteindre le premier objectif de cette thèse, une analyse post-hoc de trois études prospectives a été réalisée pour évaluer la proportion de patients chez lesquels des adénomes avancés ont été découverts et le diagnostic optique a entraîné une surveillance retardée dans trois groupes de taille de polypes : 1–3, 1–5, et 1–10 mm. Pour atteindre le second objectif de cette thèse, deux stratégies non optiques ont été développées et testées dans deux études prospectives: une stratégie de résection et d'élimination basée sur la localisation qui utilise la localisation anatomique des polypes pour classer les polypes du côlon en non-néoplasiques ou néoplasiques à faible risque et une stratégie de résection et d'élimination basée sur les polypes qui attribue des intervalles de surveillance en fonction du nombre et de la taille des polypes. Dans les trois études, la concordance de l'attribution d'intervalles de surveillance basée sur un diagnostic optique à haute confiance ou sur des stratégies non optiques avec les recommandations basées sur la pathologie, ainsi que la proportion d'examens pathologiques évités et la proportion de communications immédiates d'intervalles de surveillance, ont été évaluées. Le troisième objectif de cette thèse a été abordé par le biais d'une étude de faisabilité pilote prospective qui a utilisé la mesure de spécimens de polypes immédiatement après leur prélèvement, suite à une polypectomie par un pied à coulisse Vernier comme référence pour comparer la précision relative des mesures de la taille des polypes entre les endoscopistes et un endoscope à échelle virtuelle. Enfin, le quatrième objectif de cette thèse a été évalué par l'enregistrement et l'annotation prospective de vidéos de coloscopie. Des images non modifiées de polype, de valve iléo-caecale, d'orifice appendiculaire et de muqueuse normale ont été extraites et utilisées pour développer et tester un modèle de réseau neuronal convolutionnel profond pour classer les images pour les points de repère qu'elles contiennent. Résultats: La réduction du seuil du diagnostic optique favoriserait la sécurité du diagnostic optique en diminuant de manière significative le risque d'écarter un polype avec une histologie avancée ou la mauvaise surveillance d'un patient avec de tels polypes. En outre, les stratégies non optiques de résection et d'élimination pourraient dépasser le critère de référence d'au moins 90% de concordance dans l'attribution des intervalles de surveillance post-polypectomie par rapport aux décisions basées sur l'évaluation pathologique. De plus, il a été démontré que l'endoscope à échelle virtuelle est plus précis que l'estimation visuelle de la taille des polypes en temps réel. Enfin, un modèle d'apprentissage profond s'est révélé très efficace pour détecter les repères cæcaux, les polypes et la muqueuse normale, à la fois individuellement et en combinaison. Discussion: La prédiction histologique optique des polypes de 1 à 3 mm est une approche efficace pour améliorer la sécurité et la faisabilité de la stratégie de résection et d'écartement dans la pratique. Les approches non optiques de résection et d'élimination offrent également des alternatives viables au diagnostic optique lorsque les endoscopistes ne sont pas en mesure de répondre aux conditions de mise en œuvre systématique du diagnostic optique, ou lorsque la technologie d'amélioration de l'image n'est pas accessible. Les stratégies de résection et de rejet, qu'elles soient optiques ou non, pourraient réduire les coûts supplémentaires liés aux examens histopathologiques et faciliter la communication du prochain intervalle de surveillance le même jour que la coloscopie de référence. Un endoscope virtuel à échelle réduite faciliterait l'utilisation du diagnostic optique pour la détection des polypes diminutifs et permet une prise de décision appropriée pendant et après la coloscopie. Enfin, le modèle d'apprentissage profond peut être utile pour promouvoir et contrôler la qualité des coloscopies par la prédiction d'une coloscopie complète. Cette technologie peut être intégrée dans le cadre d'une plateforme de vérification et de génération de rapports qui élimine le besoin d'intervention humaine. Conclusion: Les résultats présentés dans cette thèse contribueront à l'état actuel des connaissances dans la pratique de la coloscopie concernant les stratégies pour améliorer l'efficacité de la coloscopie dans la prévention du cancer colorectal. Cette étude fournira des indications précieuses pour les futurs chercheurs intéressés par le développement de méthodes efficaces de traitement des polypes colorectaux diminutifs. Le diagnostic optique nécessite une formation complémentaire et une mise en œuvre à l'aide de modules de caractérisation informatisés. En outre, malgré la lenteur de l'adoption des solutions informatiques dans la pratique clinique, la coloscopie assistée par l'IA ouvrira la voie à la détection automatique, à la caractérisation et à la rédaction semi-automatique des rapports de procédure.Introduction: Colorectal cancer remains a critical public health concern in Canada. Screening programs could reduce the incidence of colorectal cancer and its associated mortality. A high-quality colonoscopy is appraised to be a cost-effective means of cancer prevention through identifying and removing cancer precursor lesions. Although colonoscopy can serve as a preventative measure against cancer, the procedure can impose an additional burden on the public health by removing and histologically evaluating insignificant diminutive colorectal polyps, which pose a minimal risk of advanced histology or cancer. The image-enhance technology would enable physicians to resect and discard diminutive polyps or diagnose and leave diminutive rectosigmoid polyps without histopathology examination. Despite the availability of computer-based polyp characterization systems, the practice of optical diagnosis remains limited due to the fear of cancer misdiagnosis, patient mismanagement, and the related medicolegal issues. Thus, alternative non-optical resection and discard strategies are imperative for improving the accuracy and safety of optical diagnosis for adaptation to clinical practice. These strategies should follow simple clinical criteria and do not require additional education or image enhanced devices. Furthermore, the safe practice of optical diagnosis, adequate decision-making regarding polypectomy technique, or surveillance interval depends on accurate polyp size estimation. The inter-endoscopist variability in polyp sizing necessitates the development of reliable and validated methods to enhance the accuracy of size measurement. A virtual scale integrated into a high-definition endoscope is currently available for automated polyp sizing, but its clinical feasibility has not yet been demonstrated. In addition to the points mentioned above, a high-quality colonoscopy requires the complete examination of the entire colonic mucosa, as well as the visualization of the ileocecal valve and appendiceal orifice. To date, no computer-based solution has been able to support endoscopists during live colonoscopies by automatically detecting and differentiating cecal landmarks. Aims: The aims of this thesis are: 1) to investigate the effect of limiting optical diagnosis to polyps 1–3mm on the safety of optical diagnosis for the management of diminutive polyps and the acceptance of endoscopists for its use in real-time practices while preserving its time- and cost-effectiveness potentials; 2) to develop and examine non-optical resect and discard strategies that can replace optical diagnosis while offering the same time- and cost-saving potentials; 3) to examine the relative accuracy of a virtual scale endoscope for measuring polyp size; 4) to train, validate, and test an artificial intelligence-empower model that can predict the completeness of a colonoscopy procedure by identifying cecal anatomical landmarks (i.e., ileocecal valve and appendiceal orifice) and differentiating them from one another, polyps, and normal mucosa. Methods: To achieve the first aim of this thesis, a post-hoc analysis of three prospective studies was performed to evaluate the proportion of patients in which advanced adenomas were found and optical diagnosis resulted in delayed surveillance in three polyp size groups: 1‒3, 1‒5, and 1‒10 mm. To achieve the second aim of this thesis, two non-optical strategies were developed and tested in two prospective studies: a location-based resect and discard strategy that uses anatomical polyp location to classify colon polyps into non-neoplastic or low-risk neoplastic and a polyp-based resect and discard strategy that assigns surveillance intervals based on polyp number and size. In all three studies, the agreement of assigning surveillance intervals based on high-confidence optical diagnosis or non-optical strategies with pathology-based recommendations, as well as the proportion of avoided pathology examinations and the proportion of immediate surveillance interval communications, was evaluated. The third aim of this thesis was addressed through a prospective pilot feasibility study that used the measurement of polyp specimens immediately after retrieving, following a polypectomy by a Vernier caliper as a reference to compare the relative accuracy of polyp size measurements between endoscopists and a virtual scale endoscope. Finally, the fourth aim of this thesis was assessed through prospective recording and annotation of colonoscopy videos. Unaltered images of polyp, ileocecal valve, appendiceal orifice and normal mucosa were extracted and used to develop and test a deep convolutional neural network model for classifying images for the containing landmarks. Results: Reducing the threshold of optical diagnosis would promote the safety of optical diagnosis by significantly decreasing the risk of discarding a polyp with advanced histology or the mismanagement of a patient with such polyps. Additionally, the non-optical resect and discard strategies could surpass the benchmark of at least 90% agreement in the assignment of post-polypectomy surveillance intervals compared with decisions based on pathologic assessment. Moreover, the virtual scale endoscope was demonstrated to be more accurate than visual estimation of polyp size in real-time. Finally, a deep learning model proved to be highly effective in detecting cecal landmarks, polyps, and normal mucosa, both individually and in combination. Discussion: Optical histology prediction of polyps 1‒3 mm in size is an effective approach to enhance the safety and feasibility of resect and discard strategy in practice. Non-optical resect and discard approaches also offer feasible alternatives to optical diagnosis when endoscopists are unable to meet the conditions for routine implementation of optical diagnosis, or when image-enhanced technology is not accessible. Both optical and non-optical resect and discard strategies could reduce additional costs related to histopathology examinations and facilitate the communication of the next surveillance interval in the same day as the index colonoscopy. A virtual scale endoscope would facilitate the use of optical diagnosis for the detection of diminutive polyps and allows for appropriate decision-making during and after colonoscopy. Additionally, the deep learning model may be useful in promoting and monitoring the quality of colonoscopies through the prediction of a complete colonoscopy. This technology may be incorporated as part of a platform for auditing and report generation that eliminates the need for human intervention. Conclusion: The results presented in this thesis will contribute to the current state of knowledge in colonoscopy practice regarding strategies for improving the efficacy of colonoscopy in the prevention of colorectal cancer. This study will provide valuable insights for future researchers interested in developing effective methods for treating diminutive colorectal polyps. Optical diagnosis requires further training and implementation using computer-based characterization modules. Furthermore, despite the slow adoption of computer-based solutions in clinical practice, AI-empowered colonoscopy will eventually pave the way for automatic detection, characterization, and semi-automated completion of procedure reports in the future
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