1,475 research outputs found

    Undergraduate Catalog of Studies, 2023-2024

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    Graduate Catalog of Studies, 2023-2024

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    Undergraduate Catalog of Studies, 2023-2024

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    Graduate Catalog of Studies, 2023-2024

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    Biological function and clinical implication of coagulation proteins during malignant transformation of pancreatic cells

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    The premalignant pancreatic cellular genotype can remain stable for years before rapid malignant transformation, often associated with inflammation. Tissue factor (TF) is an inflammatory modulator regulated by factor VIIa (fVIIa) for its levels and activity. The presence of TF in PDAC and its role in cell proliferation, angiogenesis, and metastasis suggests that TF may be a marker of the inflammatory microenvironment driving precursor lesions of pancreatic cancer. This study examined the in vitro influence of TF on pancreatic epithelial cells and its clinical value in detecting malignant transformation within pancreatic cyst fluid (PCyF). PCyF from 27 patients with pancreatic cystic lesions was analysed in a blinded fashion. TF and fVIIa levels were measured (ELISA), and the fVIIa:TF ratios were calculated. A cut-off value for TF concentration was determined and compared to the conventional assessment parameters (radiological features, CEA and amylase). Patients were categorised into four groups based on cytopathology and two groups based on indication for resection (‘resective’). Significant histological stage-dependent increases in TF levels were observed. Mean TF concentration was significantly higher (p=0.006) in the resective (high-grade dysplasia & malignant; 1.17 ng/ml, 95% CI 0.68, 1.67) vs non-resective group (benign & low-grade dysplasia; 0.27 ng/ml, 95% CI 0.1, 0.44), with a strong positive correlation (r= 0.746, p <0.001, TF cut-off 0.75 ng/ml, AUC 0.877, p=0.002). The fVIIa:TF ratio did not add further value. Incubation of pancreatic cells with recombinant TF resulted in increased expression of a marker of epithelial to mesenchymal transition (Vimentin). This influence was moderated by supplementation with fVIIa in benign (hTERT-HPNE) but not overtly malignant pancreatic cells (AsPC-1). Cyst-associated TF levels appear to correlate with cytological progression to the malignant phenotype and may allow better discrimination (specificity 94%) of the ‘resective’ lesion, reduce healthcare costs and offer a more nuanced tool for monitoring indeterminate cystic lesions

    Undergraduate Catalog of Studies, 2022-2023

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    30th European Congress on Obesity (ECO 2023)

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    This is the abstract book of 30th European Congress on Obesity (ECO 2023

    Organic Bioelectronics Development in Italy: A Review

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    In recent years, studies concerning Organic Bioelectronics have had a constant growth due to the interest in disciplines such as medicine, biology and food safety in connecting the digital world with the biological one. Specific interests can be found in organic neuromorphic devices and organic transistor sensors, which are rapidly growing due to their low cost, high sensitivity and biocompatibility. This trend is evident in the literature produced in Italy, which is full of breakthrough papers concerning organic transistors-based sensors and organic neuromorphic devices. Therefore, this review focuses on analyzing the Italian production in this field, its trend and possible future evolutions

    Selected problems of materials science. Vol. 2. Nano-dielectrics metals in electronics. Mеtamaterials. Multiferroics. Nano-magnetics

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    The textbook examines physical foundations and practical application of current electronics materials. Modern theories are presented, more important experimental data and specifications of basic materials necessary for practical application are given. Contemporary research in the field of microelectronics and nanophysics is taken into account, while special attention is paid to the influence of the internal structure on the physical properties of materials and the prospects for their use. English-language lectures and other classes on the subject of the book are held at Igor Sikorsky Kyiv Polytechnic Institute at the departments of “Applied Physics” and “Microelectronics” on the subject of materials science, which is necessary for students of higher educational institutions when performing scientific works. For master’s degree applicants in specialty 105 “Applied physics and nanomaterials”.Розглянуто фізичні основи та практичне застосування актуальних матеріалів електроніки. Подано сучасні теорії, наведено найважливіші експериментальні дані та специфікації основних матеріалів, які потрібні для практичного застосування. Враховано сучасні дослідження у галузі мікроелектроніки та нанофізики, при цьому особливу увагу приділено впливу внутрішньої структури на фізичні властивості матеріалів і на перспективи їх використання. Англомовні лекції та інші види занять за тематикою книги проводяться в КПІ ім. Ігоря Сікорського на кафедрах «Прикладна фізика» та «Мікро-електроніка» за напрямом матеріалознавство, що необхідно студентам вищих навчальних закладів при виконанні наукових робіт. Для здобувачів магістратури за спеціальністю 105 «Прикладна фізика та наноматеріали»

    2023 GREAT Day Program

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    SUNY Geneseo’s Seventeenth Annual GREAT Day. Geneseo Recognizing Excellence, Achievement & Talent Day is a college-wide symposium celebrating the creative and scholarly endeavors of our students. http://www.geneseo.edu/great_dayhttps://knightscholar.geneseo.edu/program-2007/1017/thumbnail.jp
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