6,340 research outputs found
A Nonparametric Ensemble Binary Classifier and its Statistical Properties
In this work, we propose an ensemble of classification trees (CT) and
artificial neural networks (ANN). Several statistical properties including
universal consistency and upper bound of an important parameter of the proposed
classifier are shown. Numerical evidence is also provided using various real
life data sets to assess the performance of the model. Our proposed
nonparametric ensemble classifier doesn't suffer from the `curse of
dimensionality' and can be used in a wide variety of feature selection cum
classification problems. Performance of the proposed model is quite better when
compared to many other state-of-the-art models used for similar situations
Unconventional machine learning of genome-wide human cancer data
Recent advances in high-throughput genomic technologies coupled with
exponential increases in computer processing and memory have allowed us to
interrogate the complex aberrant molecular underpinnings of human disease from
a genome-wide perspective. While the deluge of genomic information is expected
to increase, a bottleneck in conventional high-performance computing is rapidly
approaching. Inspired in part by recent advances in physical quantum
processors, we evaluated several unconventional machine learning (ML)
strategies on actual human tumor data. Here we show for the first time the
efficacy of multiple annealing-based ML algorithms for classification of
high-dimensional, multi-omics human cancer data from the Cancer Genome Atlas.
To assess algorithm performance, we compared these classifiers to a variety of
standard ML methods. Our results indicate the feasibility of using
annealing-based ML to provide competitive classification of human cancer types
and associated molecular subtypes and superior performance with smaller
training datasets, thus providing compelling empirical evidence for the
potential future application of unconventional computing architectures in the
biomedical sciences
- …