1,406 research outputs found

    A learning spectrum: an examination of early years pedagogies

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    As early childhood education policy in England directs pedagogy away from play-based approaches towards formal methods, questions about the most appropriate and effective pedagogies to use with young children have arisen. Often the debate focuses on fully child-initiated play or adult-directed lessons. However, reflecting the varying needs of children, early years pedagogy is more diverse than following one of two approaches. This research examines the range of methods used to support learning in a Reception classroom. Applying a sociocultural lens, this thesis applies Rogoff’s (1990; 1993; 1995) ‘planes of analysis’ to explore how Reception-aged children learn in school. Woven throughout this thesis, these planes identify the learning roles children adopt in different contexts. From this, the types of learning observed in the data are categorised to highlight the dynamic nature of teaching and learning. Over six months, a class of Reception children were filmed in different learning situations. The films were shown to the children and used as a stimulus to discuss the content. Data collection and analysis focused on how the children learned, interacted with one another, used adult support and applied previous learning when different pedagogical approaches were applied. Data presentation uses text discussion, excerpts of dialogue and photo stills. Highlighting the complexity of teaching and learning, the data show that adults frequently adapt methods depending on the children’s needs and interests. Much of the observed teaching and learning was neither wholly child-initiated nor adult-directed. What this study refers to as the ‘in-between pedagogies’ were the most frequently used and effective pedagogies in this Reception classroom. Furthermore, demonstrating the importance of sociocultural practices to motivate children and make learning meaningful to them, the data highlight the inseparability of the pedagogical and social aspects of teaching and learning

    In vivo multi-modal imaging approaches for cancer, stem and immune cells

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    Introduction: Molecular imaging allows for non-invasive longitudinal visualization of cellular functions in vivo. This area of research has provided better understanding of fundamental molecular and biochemical processes, enabled optimization of pre-clinical and clinical assessments for new treatments, and allowed for more accurate and early detection of many pathologies. Extensive research for novel imaging techniques and emerging technologies have rapidly advanced the field. However, an ideal single imaging modality or approach does not exist. Alternatively, multi-modal imaging approaches are commonly applied to overcome limitations of individual technologies. In this thesis, we design, develop, validate, and image various cell types using multi-modal complementary tracking systems including bioluminescence imaging (BLI), magnetic resonance imaging (MRI), magnetic particle imaging (MPI), and positron emission tomography (PET) to maximize the strengths of each technology. Methods and Results: First, we develop a multi-modal imaging approach to track breast cancer cells in a safe, sensitive, and quantitative manner in vivo. We have subsequently optimized and applied our multi-modal system further to visualize mesenchymal stem cells (MSCs), a clinically-relevant cell type, with high sensitivity. Furthermore, we have validated this imaging approach in an emerging cellular immunotherapy for the treatment of a rodent model of ovarian cancer. Specifically, using a safe dual human reporter-gene imaging approach, breast cancer cells were detectable in mice with PET and MRI - two clinical imaging modalities. Next, MSCs were genetically modified with a PET reporter gene and labelled with iron oxide nanoparticles for longitudinal imaging with clinical PET and sensitive MPI. Finally, we demonstrate chimeric antigen receptor natural killer (CAR-NK) cells slowed tumor progression in an ovarian cancer model using BLI, and were able to track the CAR-NK cells using reporter-based BLI and PET. Conclusion: The studies reported in this thesis contribute new multi-modal non-invasive molecular imaging tools to track various cell types in preclinical models to reveal complementary information on cell localization, proliferation, viability, and therapeutic response. Continued development of the clinically-relevant imaging tools we have built for tracking MSCs and CAR-NK cells may one day provide valuable information on cell therapy response/non-response or side effects in individual patients – important goals in the era of precision medicine

    Celebrating the reconciliation : potentialities of Pentecostal worship for reconciliation and peace in the context of the Great Lakes Region

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    Original doctoral dissertation: 2014, UNISA, Celebrating the reconciliation: toward a reconstructed Pentecostal worship in the Great Lakes RegionThis publication focuses on the research question: "What can the potential role of Christian worship in the Great Lakes region be to promote reconciliation and peace and healing after social and ethnic violence and conflicts?" The answer this book proposes is that a reconstructed Pentecostal Worship will significantly contribute to the process of reconciliation, peace-making, and healing of the ethnic groups in the Great Lakes region. The study theorises a Pentecostal practical theology backed in the theologies of reconstruction, politics and reconciliation. Using an empirical approach, this book draws on the spiritual, cultural, demographical and sociological potentials at the disposal of Pentecostal leaders to promote a reconstructed Pentecostal worship. It envisions a new praxis of spiritual potentials like prophecy, testimony, glossolalia, and emotional praising as opportunities to reconcile and heal people

    2010 GREAT Day Program

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    SUNY Geneseo’s Fourth Annual GREAT Day. This file has a supplement of three additional pages, linked in this record.https://knightscholar.geneseo.edu/program-2007/1004/thumbnail.jp

    General Course Catalog [2022/23 academic year]

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    General Course Catalog, 2022/23 academic yearhttps://repository.stcloudstate.edu/undergencat/1134/thumbnail.jp

    2018 GREAT Day Program

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    SUNY Geneseo’s Twelfth Annual GREAT Day.https://knightscholar.geneseo.edu/program-2007/1012/thumbnail.jp

    Data journeys in the sciences

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    This is the final version. Available from Springer via the DOI in this record. This groundbreaking, open access volume analyses and compares data practices across several fields through the analysis of specific cases of data journeys. It brings together leading scholars in the philosophy, history and social studies of science to achieve two goals: tracking the travel of data across different spaces, times and domains of research practice; and documenting how such journeys affect the use of data as evidence and the knowledge being produced. The volume captures the opportunities, challenges and concerns involved in making data move from the sites in which they are originally produced to sites where they can be integrated with other data, analysed and re-used for a variety of purposes. The in-depth study of data journeys provides the necessary ground to examine disciplinary, geographical and historical differences and similarities in data management, processing and interpretation, thus identifying the key conditions of possibility for the widespread data sharing associated with Big and Open Data. The chapters are ordered in sections that broadly correspond to different stages of the journeys of data, from their generation to the legitimisation of their use for specific purposes. Additionally, the preface to the volume provides a variety of alternative “roadmaps” aimed to serve the different interests and entry points of readers; and the introduction provides a substantive overview of what data journeys can teach about the methods and epistemology of research.European CommissionAustralian Research CouncilAlan Turing Institut
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