Near-Optimal Evasion of Convex-Inducing Classifiers

Classifiers are often used to detect miscreant activities. We study how an adversary can efficiently query a classifier to elicit information that allows the adversary to evade detection at near-minimal cost. We generalize results of Lowd and Meek (2005) to convex-inducing classifiers. We present algorithms that construct undetected instances of near-minimal cost using only polynomially many queries in the dimension of the space and without reverse engineering the decision boundary.Comment: 8 pages; to appear at AISTATS'201

Separation Options for Phosphorylated Osteopontin from Transgenic Microalgae Chlamydomonas reinhardtii.

Correct folding and post-translational modifications are vital for therapeutic proteins to elicit their biological functions. Osteopontin (OPN), a bone regenerative protein present in a range of mammalian cells, is an acidic phosphoprotein with multiple potential phosphorylation sites. In this study, the ability of unicellular microalgae, Chlamydomonas reinhardtii, to produce phosphorylated recombinant OPN in its chloroplast is investigated. This study further explores the impact of phosphorylation and expression from a "plant-like" algae on separation of OPN. Chromatography resins ceramic hydroxyapatite (CHT) and Gallium-immobilized metal affinity chromatography (Ga-IMAC) were assessed for their binding specificity to phosphoproteins. Non-phosphorylated recombinant OPN expressed in E. coli was used to compare the specificity of interaction of the resins to phosphorylated OPN. We observed that CHT binds OPN by multimodal interactions and was better able to distinguish phosphorylated proteins in the presence of 250 mM NaCl. Ga-IMAC interaction with OPN was not selective to phosphorylation, irrespective of salt, as the resin bound OPN from both algal and bacterial sources. Anion exchange chromatography proved an efficient capture method to partially separate major phosphorylated host cell protein impurities such as Rubisco from OPN

Counterfeiting and Public Health

*** This material is copyrighted and any download is for personal use only *** The original article is published in Criminal Enforcement of Intellectual Property: A Handbook of Contemporary Research edited by Christophe Geiger © 2012 Edward Elgar

The use of scanning contactless conductivity detection for the characterisation of stationary phases in micro-fluidic chips

The use of scanning capacitively coupled contactless conductivity detection for the evaluation of the structural homogeneity and density of both packed and monolithic stationary phases in microfluidic chips is presented here for the first time

Maximum-rate Transmission with Improved Diversity Gain for Interference Networks

Interference alignment (IA) was shown effective for interference management to improve transmission rate in terms of the degree of freedom (DoF) gain. On the other hand, orthogonal space-time block codes (STBCs) were widely used in point-to-point multi-antenna channels to enhance transmission reliability in terms of the diversity gain. In this paper, we connect these two ideas, i.e., IA and space-time block coding, to improve the designs of alignment precoders for multi-user networks. Specifically, we consider the use of Alamouti codes for IA because of its rate-one transmission and achievability of full diversity in point-to-point systems. The Alamouti codes protect the desired link by introducing orthogonality between the two symbols in one Alamouti codeword, and create alignment at the interfering receiver. We show that the proposed alignment methods can maintain the maximum DoF gain and improve the ergodic mutual information in the long-term regime, while increasing the diversity gain to 2 in the short-term regime. The presented examples of interference networks have two antennas at each node and include the two-user X channel, the interferring multi-access channel (IMAC), and the interferring broadcast channel (IBC).Comment: submitted to IEEE Transactions on Information Theor

Missed the Goal for Workers: The Reality of Soccer Ball Stitchers in Pakistan, India, China and Thailand

This report presents the key findings of the International Labor Rights Forum’s research in the four largest soccer balls producing countries: Pakistan, India, China and Thailand. This report also highlights the need to rethink the strategies being utilized by companies to encourage suppliers to adhere to strong labor standards

Biochemical analysis of TssK, a core component of the bacterial Type VI secretion system, reveals distinct oligomeric states of TssK and identifies a TssK–TssFG subcomplex

Gram-negative bacteria use the Type VI secretion system (T6SS) to inject toxic proteins into rival bacteria or eukaryotic cells. However, the mechanism of the T6SS is incompletely understood. In the present study, we investigated a conserved component of the T6SS, TssK, using the antibacterial T6SS of Serratia marcescens as a model system. TssK was confirmed to be essential for effector secretion by the T6SS. The native protein, although not an integral membrane protein, appeared to localize to the inner membrane, consistent with its presence within a membrane-anchored assembly. Recombinant TssK purified from S. marcescens was found to exist in several stable oligomeric forms, namely trimer, hexamer and higher-order species. Native-level purification of TssK identified TssF and TssG as interacting proteins. TssF and TssG, conserved T6SS components of unknown function, were required for T6SS activity, but not for correct localization of TssK. A complex containing TssK, TssF and TssG was subsequently purified in vitro, confirming that these three proteins form a new subcomplex within the T6SS. Our findings provide new insight into the T6SS assembly, allowing us to propose a model whereby TssK recruits TssFG into the membrane-associated T6SS complex and different oligomeric states of TssK may contribute to the dynamic mechanism of the system

Nonregenerative MIMO Relaying with Optimal Transmit Antenna Selection

We derive optimal SNR-based transmit antenna selection rules at the source and relay for the nonregenerative half duplex MIMO relay channel. While antenna selection is a suboptimal form of beamforming, it has the advantage that the optimization is tractable and can be implemented with only a few bits of feedback from the destination to the source and relay. We compare the bit error rate of optimal antenna selection at both the source and relay to other proposed beamforming techniques and propose methods for performing the necessary limited feedback