The case for metadata harvesting

Metadata harvesting is an increasingly popular model of interaction between the mutually autonomous parties of medium, medium-large federations of digital library services. With a harvesting protocol, in particular, resource descriptions locally available at each party can be served to remote applications for the implementation of federated services, such as resource discovery. This article offers a systematic explanation of the success of the model and its standard implementations in the context of current initiatives for national and international federations

Host immune response to cytomegalovirus

To confirm that immediate-early (IE) genes of murine cytomegalovirus (MCMV) give rise to antigens recognized by specific cytolytic T lymphocytes (CTL), a 10.8-kilobase fragment of MCMV DNA which is abundantly transcribed at IE times was transfected into L cells expressing the Ld class I major histocompatibility glycoprotein. The viral genome fragment contains sequences of the three IE transcription units of MCMV: ie1, ie2, and ie3. In the transfected cell lines, only the predominant 2.75-kilobase transcript of ie1 and its translation product pp89 could be detected. The transfectants were analyzed for membrane expression of an IE antigen by employing clone IE1, an IE-specific CTL clone, as the probe. Only cells that expressed both the MCMV IE gene(s) and the Ld gene were recognized by the CTL clone

Information encountering re-encountered: A conceptual re-examination of serendipity in the context of information acquisition

Purpose In order to understand the totality, diversity and richness of human information behavior, increasing research attention has been paid to examining serendipity in the context of information acquisition. However, several issues have arisen as this research subfield has tried to find its feet; we have used different, inconsistent terminology to define this phenomenon (e.g. information encountering, accidental information discovery, incidental information acquisition), the scope of the phenomenon has not been clearly defined and its nature was not fully understood or fleshed-out. Design/methodology/approach In this paper, information encountering (IE) was proposed as the preferred term for serendipity in the context of information acquisition. Findings A reconceptualized definition and scope of IE was presented, a temporal model of IE and a refined model of IE that integrates the IE process with contextual factors and extends previous models of IE to include additional information acquisition activities pre- and postencounter. Originality/value By providing a more precise definition, clearer scope and richer theoretical description of the nature of IE, there was hope to make the phenomenon of serendipity in the context of information acquisition more accessible, encouraging future research consistency and thereby promoting deeper, more unified theoretical development

The isotope effect in the Hubbard model with local phonons

The isotope effect (IE) in the two-dimensional Hubbard model with Holstein phonons is studied using the dynamical cluster approximation with quantum Monte Carlo. At small electron-phonon (EP) coupling the IE is negligible. For larger EP coupling there is a large and positive IE on the superconducting temperature that decreases with increasing doping. A significant IE also appears in the low-energy density of states, kinetic energy and charge excitation spectrum. A negligible IE is found in the pseudogap and antiferromagnetic (AF) properties at small doping whereas the AF susceptibility at intermediate doping increases with decreasing phonon frequency $\omega_0$. This IE stems from increased polaronic effects with decreasing $\omega_0$. A larger IE at smaller doping occurs due to stronger polaronic effects determined by the interplay of the EP interaction with stronger AF correlations. The IE of the Hubbard-Holstein model exhibits many similarities with the IE measured in cuprate superconductors

Will the real ventricular architecture please stand up?

Ventricular twisting, essential for cardiac function, is attributed to the contraction of myocardial helical fibers. The exact relationship between ventricular anatomy and function remains to be determined, but one commonly used explanatory model is the helical ventricular myocardial band (HVMB) model of Torrent-Guasp. This model has been successful in explaining many aspects of ventricular function, (Torrent-Guasp et al. Eur. J. Cardiothorac. Surg., 25, 376, 2004; Buckberg et al. Eur. J. Cardiothorac. Surg., 47, 587, 2015; Buckberg et al. Eur. J. Cardiothorac. Surg. 47, 778, 2015) but the model ignores important aspects of ventricular anatomy and should probably be replaced. The purpose of this review is to compare the HVMB model with a different model (nested layers). A complication when interpreting experimental observations that relate anatomy to function is that, in the myocardium, shortening does not always imply activation and lengthening does not always imply inactivation

The rationale for a wider concept of Inclusive Education for teacher education: A case-study of Serbia

Teacher education for inclusive education (IE) is recognized as vital for improving quality and equity in education globally. In the Western Balkan countries it is also part of the transition process towards joining the European Union and has attracted international funding for IE-related projects. A key finding from research funded by the European Training Foundation, carried out by the authors as members of a seven-country research team in 2009-2010, was that the prevailing local understanding of IE was very narrow. In this article we hypothesize the reasons for this finding. We use a case study of school and teacher education systems in Serbia to explore how this understanding has constrained the development of IE and associated teacher education and limited the efficacy of some recent internationally supported developments. We identify both challenges and possible ways forward for teacher education for IE based on promoting a concept of IE that is both collaboratively agreed and comprehensive. © 2012 UNESCO IBE

Requirements for Information Extraction for Knowledge Management

Knowledge Management (KM) systems inherently suffer from the knowledge acquisition bottleneck - the difficulty of modeling and formalizing knowledge relevant for specific domains. A potential solution to this problem is Information Extraction (IE) technology. However, IE was originally developed for database population and there is a mismatch between what is required to successfully perform KM and what current IE technology provides. In this paper we begin to address this issue by outlining requirements for IE based KM

An investigation of herpes simplex virus promoter activity compatible with latency establishment reveals VP16-independent activation of immediate-early promoters in sensory neurones

Herpes simplex virus (HSV) type-1 establishes lifelong latency in sensory neurones and it is widely assumed that latency is the consequence of a failure to initiate virus immediate-early (IE) gene expression. However, using a Ore reporter mouse system in conjunction with Ore-expressing HSV-1 recombinants we have previously shown that activation of the IE ICPO promoter can precede latency establishment in at least 30 % of latently infected cells. During productive infection of non-neuronal cells, IE promoter activation is largely dependent on the transactivator VP16 a late structural component of the virion. Of significance, VP16 has recently been shown to exhibit altered regulation in neurones; where its de novo synthesis is necessary for IE gene expression during both lytic infection and reactivation from latency. In the current study, we utilized the Ore reporter mouse model system to characterize the full extent of viral promoter activity compatible with cell survival and latency establishment. In contrast to the high frequency activation of representative IE promoters prior to latency establishment, cell marking using a virus recombinant expressing Ore under VP16 promoter control was very inefficient. Furthermore, infection of neuronal cultures with VP16 mutants reveals a strong VP16 requirement for IE promoter activity in non-neuronal cells, but not sensory neurones. We conclude that only IE promoter activation can efficiently precede latency establishment and that this activation is likely to occur through a VP16-independent mechanism