Muscle synergies in neuroscience and robotics: from input-space to task-space perspectives

In this paper we review the works related to muscle synergies that have been carried-out in neuroscience and control engineering. In particular, we refer to the hypothesis that the central nervous system (CNS) generates desired muscle contractions by combining a small number of predefined modules, called muscle synergies. We provide an overview of the methods that have been employed to test the validity of this scheme, and we show how the concept of muscle synergy has been generalized for the control of artificial agents. The comparison between these two lines of research, in particular their different goals and approaches, is instrumental to explain the computational implications of the hypothesized modular organization. Moreover, it clarifies the importance of assessing the functional role of muscle synergies: although these basic modules are defined at the level of muscle activations (input-space), they should result in the effective accomplishment of the desired task. This requirement is not always explicitly considered in experimental neuroscience, as muscle synergies are often estimated solely by analyzing recorded muscle activities. We suggest that synergy extraction methods should explicitly take into account task execution variables, thus moving from a perspective purely based on input-space to one grounded on task-space as well

Degraded Synergistic Recruitment of sEMG Oscillations for Cerebral Palsy Infants Crawling

Background: Synergistic recruitment of muscular activities is a generally accepted mechanism for motor function control, and motor dysfunction, such as cerebral palsy (CP), destroyed the synergistic electromyography activities of muscle group for limb movement. However, very little is known how motor dysfunction of CP affects the organization of the myoelectric frequency components due to the abnormal motor unit recruiting patterns.Objectives: Exploring whether the myoelectric activity can be represented with synergistic recruitment of surface electromyography (sEMG) frequency components; evaluating the effect of CP motor dysfunction on the synergistic recruitment of sEMG oscillations.Methods: Twelve CP infants and 17 typically developed (TD) infants are recruited for self-paced crawling on hands and knees. sEMG signals have been recorded from bilateral biceps brachii (BB) and triceps brachii (TB) muscles. Multi-scale oscillations are extracted via multivariate empirical mode decomposition (MEMD), and non-negative matrix factorization (NMF) method is employed to obtain synergistic pattern of these sEMG oscillations. The coefficient curve of sEMG oscillation synergies are adopted to quantify the time-varying recruitment of BB and TB myoelectric activity during infants crawling.Results: Three patterns of sEMG oscillation synergies with specific frequency ranges are extracted in BB and TB of CP or TD infants. The contribution of low-frequency oscillation synergy of BB in CP group is significantly less than that in TD group (p < 0.05) during forward swing phase for slow contraction; however, this low-frequency oscillation synergy keep higher level during the backward swing phase crawling. For the myoelectric activities of TB, there is not enough high-frequency oscillation recruitment of sEMG for the fast contraction in propulsive phase of CP infants crawling.Conclusion: Our results reveal that, the myoelectric activities of a muscle can be manifested as sEMG oscillation synergies, and motor dysfunction of CP degrade the synergistic recruitment of sEMG oscillations due to the impaired CNS regulation and destroyed MU/muscle fiber. Our preliminary work suggests that time-varying coefficient curve of sEMG oscillation synergies is a potential index to evaluate the abnormal recruitment of electromyography activities affected by CP disorders

Advancing Medical Technology for Motor Impairment Rehabilitation: Tools, Protocols, and Devices

Excellent motor control skills are necessary to live a high-quality life. Activities such as walking, getting dressed, and feeding yourself may seem mundane, but injuries to the neuromuscular system can render these tasks difficult or even impossible to accomplish without assistance. Statistics indicate that well over 100 million people are affected by diseases or injuries, such as stroke, Parkinson’s Disease, Multiple Sclerosis, Cerebral Palsy, peripheral nerve injury, spinal cord injury, and amputation, that negatively impact their motor abilities. This wide array of injuries presents a challenge to the medical field as optimal treatment paradigms are often difficult to implement due to a lack of availability of appropriate assessment tools, the inability for people to access the appropriate medical centers for treatment, or altogether gaps in technology for treating the underlying impairments causing the disability. Addressing each of these challenges will improve the treatment of movement impairments, provide more customized and continuous treatment to a larger number of patients, and advance rehabilitative and assistive device technology. In my research, the key approach was to develop tools to assess and treat upper extremity movement impairment. In Chapter 2.1, I challenged a common biomechanical[GV1] modeling technique of the forearm. Comparing joint torque values through inverse dynamics simulation between two modeling platforms, I discovered that representing the forearm as a single cylindrical body was unable to capture the inertial parameters of a physiological forearm which is made up of two segments, the radius and ulna. I split the forearm segment into a proximal and distal segment, with the rationale being that the inertial parameters of the proximal segment could be tuned to those of the ulna and the inertial parameters of the distal segment could be tuned to those of the radius. Results showed a marked increase in joint torque calculation accuracy for those degrees of freedom that are affected by the inertial parameters of the radius and ulna. In Chapter 2.2, an inverse kinematic upper extremity model was developed for joint angle calculations from experimental motion capture data, with the rationale being that this would create an easy-to-use tool for clinicians and researchers to process their data. The results show accurate angle calculations when compared to algebraic solutions. Together, these chapters provide easy-to-use models and tools for processing movement assessment data. In Chapter 3.1, I developed a protocol to collect high-quality movement data in a virtual reality task that is used to assess hand function as part of a Box and Block Test. The goal of this chapter is to suggest a method to not only collect quality data in a research setting but can also be adapted for telehealth and at home movement assessment and rehabilitation. Results indicate that the data collected in this protocol are good and the virtual nature of this approach can make it a useful tool for continuous, data driven care in clinic or at home. In Chapter 3.2 I developed a high-density electromyography device for collecting motor unit action potentials of the arm. Traditional surface electromyography is limited by its ability to obtain signals from deep muscles and can also be time consuming to selectively place over appropriate muscles. With this high-density approach, muscle coverage is increased, placement time is decreased, and deep muscle activity can potentially be collected due to the high-density nature of the device[GV2] . Furthermore, the high-density electromyography device is built as a precursor to a high-density electromyography-electrical stimulation device for functional electrical stimulation. The customizable nature of the prototype in Chapter 3.2 allows for the implementation both recording and stimulating electrodes. Furthermore, signal results show that the electromyography data obtained from the device are of high quality and are correlated with gold standard surface electromyography sensors. One key factor in a device that can record and then stimulate based on the information from the recorded signals is an accurate movement intent decoder. High-quality movement decoders have been designed by closed-loop device controllers in the past, but they still struggle when the user interacts with objects of varying weight due to underlying alterations in muscle signals. In Chapter 4, I investigate this phenomenon by administering an experiment where participants perform a Box and Block Task with objects of 3 different weights, 0 kg, 0.02 kg, and 0.1 kg. Electromyography signals of the participants right arm were collected and co-contraction levels between antagonistic muscles were analyzed to uncover alterations in muscle forces and joint dynamics. Results indicated contraction differences between the conditions and also between movement stages (contraction levels before grabbing the block vs after touching the block) for each condition. This work builds a foundation for incorporating object weight estimates into closed-loop electromyography device movement decoders. Overall, we believe the chapters in this thesis provide a basis for increasing availability to movement assessment tools, increasing access to effective movement assessment and rehabilitation, and advance the medical device and technology field

Human skill capturing and modelling using wearable devices

Industrial robots are delivering more and more manipulation services in manufacturing. However, when the task is complex, it is difficult to programme a robot to fulfil all the requirements because even a relatively simple task such as a peg-in-hole insertion contains many uncertainties, e.g. clearance, initial grasping position and insertion path. Humans, on the other hand, can deal with these variations using their vision and haptic feedback. Although humans can adapt to uncertainties easily, most of the time, the skilled based performances that relate to their tacit knowledge cannot be easily articulated. Even though the automation solution may not fully imitate human motion since some of them are not necessary, it would be useful if the skill based performance from a human could be firstly interpreted and modelled, which will then allow it to be transferred to the robot. This thesis aims to reduce robot programming efforts significantly by developing a methodology to capture, model and transfer the manual manufacturing skills from a human demonstrator to the robot. Recently, Learning from Demonstration (LfD) is gaining interest as a framework to transfer skills from human teacher to robot using probability encoding approaches to model observations and state transition uncertainties. In close or actual contact manipulation tasks, it is difficult to reliabley record the state-action examples without interfering with the human senses and activities. Therefore, wearable sensors are investigated as a promising device to record the state-action examples without restricting the human experts during the skilled execution of their tasks. Firstly to track human motions accurately and reliably in a defined 3-dimensional workspace, a hybrid system of Vicon and IMUs is proposed to compensate for the known limitations of the individual system. The data fusion method was able to overcome occlusion and frame flipping problems in the two camera Vicon setup and the drifting problem associated with the IMUs. The results indicated that occlusion and frame flipping problems associated with Vicon can be mitigated by using the IMU measurements. Furthermore, the proposed method improves the Mean Square Error (MSE) tracking accuracy range from 0.8˚ to 6.4˚ compared with the IMU only method. Secondly, to record haptic feedback from a teacher without physically obstructing their interactions with the workpiece, wearable surface electromyography (sEMG) armbands were used as an indirect method to indicate contact feedback during manual manipulations. A muscle-force model using a Time Delayed Neural Network (TDNN) was built to map the sEMG signals to the known contact force. The results indicated that the model was capable of estimating the force from the sEMG armbands in the applications of interest, namely in peg-in-hole and beater winding tasks, with MSE of 2.75N and 0.18N respectively. Finally, given the force estimation and the motion trajectories, a Hidden Markov Model (HMM) based approach was utilised as a state recognition method to encode and generalise the spatial and temporal information of the skilled executions. This method would allow a more representative control policy to be derived. A modified Gaussian Mixture Regression (GMR) method was then applied to enable motions reproduction by using the learned state-action policy. To simplify the validation procedure, instead of using the robot, additional demonstrations from the teacher were used to verify the reproduction performance of the policy, by assuming human teacher and robot learner are physical identical systems. The results confirmed the generalisation capability of the HMM model across a number of demonstrations from different subjects; and the reproduced motions from GMR were acceptable in these additional tests. The proposed methodology provides a framework for producing a state-action model from skilled demonstrations that can be translated into robot kinematics and joint states for the robot to execute. The implication to industry is reduced efforts and time in programming the robots for applications where human skilled performances are required to cope robustly with various uncertainties during tasks execution

The "Federica" hand: a simple, very efficient prothesis

Hand prostheses partially restore hand appearance and functionalities. Not everyone can afford expensive prostheses and many low-cost prostheses have been proposed. In particular, 3D printers have provided great opportunities by simplifying the manufacturing process and reducing costs. Generally, active prostheses use multiple motors for fingers movement and are controlled by electromyographic (EMG) signals. The "Federica" hand is a single motor prosthesis, equipped with an adaptive grasp and controlled by a force-myographic signal. The "Federica" hand is 3D printed and has an anthropomorphic morphology with five fingers, each consisting of three phalanges. The movement generated by a single servomotor is transmitted to the fingers by inextensible tendons that form a closed chain; practically, no springs are used for passive hand opening. A differential mechanical system simultaneously distributes the motor force in predefined portions on each finger, regardless of their actual positions. Proportional control of hand closure is achieved by measuring the contraction of residual limb muscles by means of a force sensor, replacing the EMG. The electrical current of the servomotor is monitored to provide the user with a sensory feedback of the grip force, through a small vibration motor. A simple Arduino board was adopted as processing unit. The differential mechanism guarantees an efficient transfer of mechanical energy from the motor to the fingers and a secure grasp of any object, regardless of its shape and deformability. The force sensor, being extremely thin, can be easily embedded into the prosthesis socket and positioned on both muscles and tendons; it offers some advantages over the EMG as it does not require any electrical contact or signal processing to extract information about the muscle contraction intensity. The grip speed is high enough to allow the user to grab objects on the fly: from the muscle trigger until to the complete hand closure, "Federica" takes about half a second. The cost of the device is about 100 US$. Preliminary tests carried out on a patient with transcarpal amputation, showed high performances in controlling the prosthesis, after a very rapid training session. The "Federica" hand turned out to be a lightweight, low-cost and extremely efficient prosthesis. The project is intended to be open-source: all the information needed to produce the prosthesis (e.g. CAD files, circuit schematics, software) can be downloaded from a public repository. Thus, allowing everyone to use the "Federica" hand and customize or improve it

Decoding motor neuron behavior for advanced control of upper limb prostheses

One of the main challenges in upper limb prosthesis control to date is to provide devices intuitive to use and capable to reproduce the natural movements of the arm and hand. One approach to solve this challenge is to use the same control signals for prosthesis control that our nervous system uses to control its muscles. This thesis aims to investigate the possibility of natural, intuitive prosthesis control using neural information obtained with available surface EMG decomposition methods. In order to explore all aspects of such a novel approach, a series of five studies were performed with the final goal of implementing a proof of concept and comparing its performance with state of the art myoelectric control. The performed investigations revealed important insights in motor unit physiology after targeted muscle reinnervation, EMG decomposition in dynamic voluntary contractions of the forearm, and the properties and challenges of neural information based prosthesis control. The main outcome of the thesis is that neural information based prosthesis control is capable to outperform myoelectric approaches in pattern recognition, linear regression and nonlinear regression, as determined by offline performance comparisons. The final proof of concept for this novel approach was a robust regression method based on neuromusculoskeletal modeling. The kinematics estimation of the proposed approach outperformed EMG-based nonlinear regression in both able-bodied subjects and patients with limb deficiency, indicating that using neural information is a promising avenue for advanced myoelectric control.2017-11-3

Biceps brachii synergy and its contribution to target reaching tasks within a virtual cube

Ces dernières années, des travaux importants ont été observés dans le développement du contrôle prothétique afin d'aider les personnes amputées du membre supérieur à améliorer leur qualité de vie au quotidien. Certaines prothèses myoélectriques modernes des membres supérieurs disponibles dans le commerce ont de nombreux degrés de liberté et nécessitent de nombreux signaux de contrôle pour réaliser plusieurs tâches fréquemment utilisées dans la vie quotidienne. Pour obtenir plusieurs signaux de contrôle, de nombreux muscles sont requis mais pour les personnes ayant subi une amputation du membre supérieur, le nombre de muscles disponibles est plus ou moins réduit selon le niveau de l’amputation. Pour accroître le nombre de signaux de contrôle, nous nous sommes intéressés au biceps brachial, vu qu’anatomiquement il est formé de 2 chefs et que de la présence de compartiments a été observée sur sa face interne. Physiologiquement, il a été trouvé que les unités motrices du biceps sont activées à différents endroits du muscle lors de la production de diverses tâches fonctionnelles. De plus, il semblerait que le système nerveux central puisse se servir de la synergie musculaire pour arriver à facilement produire plusieurs mouvements. Dans un premier temps on a donc identifié que la synergie musculaire était présente chez le biceps de sujets normaux et on a montré que les caractéristiques de cette synergie permettaient d’identifier la posture statique de la main lorsque les signaux du biceps avaient été enregistrés. Dans un deuxième temps, on a réussi à démontrer qu’il était possible, dans un cube présenté sur écran, à contrôler la position d’une sphère en vue d’atteindre diverses cibles en utilisant la synergie musculaire du biceps. Les techniques de classification utilisées pourraient servir à faciliter le contrôle des prothèses myoélectriques.In recent years, important work has been done in the development of prosthetic control to help upper limb amputees improve their quality of life on a daily basis. Some modern commercially available upper limb myoelectric prostheses have many degrees of freedom and require many control signals to perform several tasks commonly used in everyday life. To obtain several control signals, many muscles are required, but for people with upper limb amputation, the number of muscles available is more or less reduced, depending on the level of amputation. To increase the number of control signals, we were interested in the biceps brachii, since it is anatomically composed of 2 heads and the presence of compartments was observed on its internal face. Physiologically, it has been found that the motor units of the biceps are activated at different places of the muscle during production of various functional tasks. In addition, it appears that the central nervous system can use muscle synergy to easily produce multiple movements. In this research, muscle synergy was first identified to be present in the biceps of normal subjects, and it was shown that the characteristics of this synergy allowed the identification of static posture of the hand when the biceps signals had been recorded. In a second investigation, we demonstrated that it was possible in a virtual cube presented on a screen to control online the position of a sphere to reach various targets by using muscle synergy of the biceps. Classification techniques have been used to improve the classification of muscular synergy features, and these classification techniques can be integrated with control algorithm that produces dynamic movement of myoelectric prostheses to facilitate the training of prosthetic control

Humanoid Robots

For many years, the human being has been trying, in all ways, to recreate the complex mechanisms that form the human body. Such task is extremely complicated and the results are not totally satisfactory. However, with increasing technological advances based on theoretical and experimental researches, man gets, in a way, to copy or to imitate some systems of the human body. These researches not only intended to create humanoid robots, great part of them constituting autonomous systems, but also, in some way, to offer a higher knowledge of the systems that form the human body, objectifying possible applications in the technology of rehabilitation of human beings, gathering in a whole studies related not only to Robotics, but also to Biomechanics, Biomimmetics, Cybernetics, among other areas. This book presents a series of researches inspired by this ideal, carried through by various researchers worldwide, looking for to analyze and to discuss diverse subjects related to humanoid robots. The presented contributions explore aspects about robotic hands, learning, language, vision and locomotion

Mechanosensitivity and Neural Adaptation in Human Somatosensory System

Magnetoencephalography (MEG) was utilized to characterize the adaptation in the somatosensory cortical network due to repeated cutaneous tactile stimulation applied unilaterally on the face and hand using a custom-built pneumatic stimulator called the TAC-Cell. Face stimulation invoked neuromagnetic responses reflecting cortical activity in the contralateral primary somatosensory cortex (SI), while hand stimulation resulted in robust contralateral SI and posterior parietal cortex (PPC) activation. There was also activity observed in regions of the secondary somatosensory cortical areas (SII), although with a reduced amplitude and higher variability across subjects. There was a significant difference in adaptation rates between SI, and higher-order sensory cortices like the PPC for hand stimulation. Adaptation was also significantly dependent on the stimulus frequency and pulse index number within the stimulus train for both hand and face stimulation. The latency of the peak responses was significantly dependent on stimulus site and response component (SI, PPC). The difference in the latency of peak SI and PPC responses can be reflective of a hierarchical serial-processing network in the somatosensory cortex. Age- and sex-related changes of vibrotactile sensitivity in the orofacial and hand skin surfaces of healthy adults was demonstrated using an established psychophysical protocol. Vibrotactile threshold sensitivity increased as a function of age for finger stimulation, but remained unaltered for the face. Increase in the finger threshold sensitivity is due to age-related changes in the number and morphology of Pacinian corpuscles (absent in the face). Vibrotactile threshold sensitivity is significantly dependent on stimulation site, stimulus frequency, and sex of the participant. These differences are presumably due to dissimilarities in the type and density of mechanoreceptors present in the face and hand. A novel-method was developed to couple the use of fiber-optic displacement sensors with the pneumatic stimulator built in our laboratory called the TAC-Cell. This displacement sensor which is commonly used in industrial applications was successfully utilized to characterize the skin response to TAC-Cell stimulation. Skin displacement was significantly dependent on input stimulus amplitudes and varied as a function of the participants' sex. Power spectrum analysis and rise-fall time measurement of the skin-displacement showed that the TAC-Cell stimulus consists of a spectrally rich, high velocity signal that is capable of evoking a cortical response due to stimulation of the medial-lemniscus and trigeminal pathways