Circumscribed Palmar Hypokeratosis – The First Case from South-East Europe

Circumscribed palmar or plantar hypokeratosis (CPH) is a rare epidermal malformation, usually asymptomatic, consisting of a well-demarcated erythema with central depression and hyperkeratotic border which divides it from the normal skin. We report a 77-year-old woman with characteristic lesion of circumscribed palmar hypokeratosis on the right palm. Clinically, the lesion simulated porokeratosis of Mibelli, but histologically there was no cornoid lamella, while the characteristic depression of epidermis, with sharp stair in stratum corneum between the normal and involved skin was present. This is the first case of CPH diagnosed in the south-east of Europe. After a 9-year follow-up period and various treatment modalities, we confirmed the resistance of CPH. Since malignant transformation has been documented, a careful follow-up is to be recommended.</p