Human complement factor H

We isolated cDNA clones coding for the functionally important tryptic N-terminal38- kDa fragment of human complement control protein factor H using polyclonal and monoclonal antibodies to screen a human liver cDNA library cloned in a bacterial expression vector, PEX-1. By testing the reactivity of antibodies specific for the recombinant proteins produced by individual clones with proteolytic fragments of serum H the exact position of these cDNA clones within H was mapped. One clone, H-19, coding for the 38-kDa fragment of H was sequenced and found to code for 289 amino acids derived from the 38-kDa N-terminal fragment as well as for the first 108 amino acids belonging to the complementary 142-kDa tryptic fragment. The derived protein sequence could be arranged in 6 highly homologous repeats of about 60 amino acids each, the homology between the repeats being determined by the characteristic position of cysteine, proline, glycine, tyrosine and tryptophane residues. The region coding for the epitope recognized by one of our monoclonal antibodies was localized by subcloning restriction fragments of H-19 into the expression plasmid and testing for the expression of this epitope

Kajian Human Factor SDM Ground Handling di Bandar Udara Adi Sucipto YOGYAKARTA

Penanganan pesawat di bandar udara atau ground handling mempunyai fungsi dan peranan penting dalam menjaga keselamatan penerbangan. Sesuai prosedur dalam sistem operasional harus benar benar ditaati dan dijalankan. Peristiwa yang pernah terjadi pada Turkish Airlines penerbangan nomor 981 yang melakukan penerbangan dari Istanbul, Turki menuju London melalui Paris kemudian pada tanggal 3 Maret 1974, pesawat tersebut berakhir celaka sesaat setelah keluar wilayah Paris. Pintu kargo di bagian belakang bawah pesawat terlepas. Menyebabkan dekompresi dan memutus kabel kabel kontrol pesawat. Pilot kehilangan kontrol atas pesawat sehingga pesawat kemudian jatuh menukik. Semua penumpang dan awak pesawat McDonnel Douglas DC 10 yang berjumlah 346 ditemukan tewas. Sebagai upaya dalam meningkatkan keselamatan penerbangan khususnya di bandar udara, maka perlu dilakukan kajian tentang human factor tentang ground handling di sisi udara. Maksud kajian adalah untuk mengevaluasi bagaimana peran ground handling di bandar udara dan bagaimana manajemen dalam mencegah faktor human error. Kajian human factor personel ground handling di Bandara Adi Sucipto yang difokuskan pada sisi udara menemukan hasil bahwa pekerjaan ground handling yang mempunyai human error probability HEP tertinggi personel ground handling dalam menjalankan tugasnya adalah terburu buru menempatkan forward airstair sehingga menabrak pesawat, bagasi yang jatuh dari bag carts dan tugs and tractor saling bertabrakan karena area sempit. Seluruhnya mendapat nilai 0.1800 sedangkan HEP operator tidak melock forward airstairs mendapatkan nilai 0.0900 [The Study of Human Factor of Ground Handling Human Resources in Yogyakarta Adi Sucipto Airport] The aircraft handling in the airport, named as ground handling, has important role and function in maintaining the aviation safety. In accordance with the stated procedures, ground handling operations must be obeyed and held appropriately. The accident related with aircraft mishandling was happened on Turkish Airlines flight number 981 which departed from Istanbul, Turkey, to London via Paris at 3 March 1974, The accident took place shortly after flew out of Paris area. The cargo door at the lower aft of aircraft was detached and causing decompression and cutting off the control cables of the aircraft. The pilot lost control and the aircraft crashed. All 346 of the passengers and cabin crews of the McDonnel Douglas DC 10 aircraft found dead. In the effort of improving the aviation safety, particularly in the airport, it is necessary to examine the human factor of ground handling in the air side of the airport. The purpose of this study is to evaluate the role of ground handling and propose the operational management which can prevent the occurrence of human error. The results of this study indicate that ground handling works with high Human Error Probability HEP are forward air stair that is placed hastily by ground handling personnel that it collides with the aircraft, falling baggage from bag carts, and collision of tugs and tractor due to narrow area. All of three works with high HEP have the score of 0.1800 whilst the operator who does not lock the forward air stair has the score of 0.090

The Effect of Personal Health on the Formation of Human Capital: a Metasystem Approach

In article the problem of influence of the personality's health on formation of the human capital is considered. Authors have conducted theoretical researches of the existing knowledge of the human capital and justifications of influence of the personality's health on its formation are given. On the basis of the carried-out analysis it is established that now the personality's health is a significant factor of efficiency of any kind of activity and important quality of the personality, therefore, it can be considered as a factor of formation of the human capital. According to it need of determination of criteria, the indicators of health of the personality influencing formation and development of the human capital was designated

Environment, Human, Problems, Needs & Information! How dose arrange this puzzle? What is the information gathering (IG)?

The environment is a field that interaction between world elements was occurred on it. The environment produces some information, and affects other elements that exist on that field. This interaction can be defined as processes. On the other hand, the human factor as an element, produce some information and take other. In this process, the human factor may be passive or active. This processes and the way of information gathering were explained in this paper

Aneuploidy and proteotoxic stress in cancer

Although nearly ubiquitous in cancer, aneuploidy exerts detrimental effects on human cells. We recently demonstrated that aneuploid human cells exhibit impaired heat shock factor protein 1 (HSF1) and HSP90 function, suggesting a functional link between two recurring features of cancer cells: aneuploidy and proteotoxic stress. Further, our fi ndings implicate HSF1 as a key factor in mitigating the effects of aneuploid

The influence of global intellectualization on human development

In the context of the global intellectualization, human capital is the determining factor in the innovation development and the international competitiveness of countries. In the XXI century. the leading component of human capital are qualitatively new information, communication and network technologies. Particular importance are education and training, professionalism, high level of human resources management, building up, reproduction and human capital development. These factors are the prerequisite for the growth of the competitive advantages of the country in the conditions of globalization