Deep Neural Ensemble for Retinal Vessel Segmentation in Fundus Images towards Achieving Label-free Angiography

Automated segmentation of retinal blood vessels in label-free fundus images entails a pivotal role in computed aided diagnosis of ophthalmic pathologies, viz., diabetic retinopathy, hypertensive disorders and cardiovascular diseases. The challenge remains active in medical image analysis research due to varied distribution of blood vessels, which manifest variations in their dimensions of physical appearance against a noisy background. In this paper we formulate the segmentation challenge as a classification task. Specifically, we employ unsupervised hierarchical feature learning using ensemble of two level of sparsely trained denoised stacked autoencoder. First level training with bootstrap samples ensures decoupling and second level ensemble formed by different network architectures ensures architectural revision. We show that ensemble training of auto-encoders fosters diversity in learning dictionary of visual kernels for vessel segmentation. SoftMax classifier is used for fine tuning each member auto-encoder and multiple strategies are explored for 2-level fusion of ensemble members. On DRIVE dataset, we achieve maximum average accuracy of 95.33\% with an impressively low standard deviation of 0.003 and Kappa agreement coefficient of 0.708 . Comparison with other major algorithms substantiates the high efficacy of our model.Comment: Accepted as a conference paper at IEEE EMBC, 201

Deep Learning in Cardiology

The medical field is creating large amount of data that physicians are unable to decipher and use efficiently. Moreover, rule-based expert systems are inefficient in solving complicated medical tasks or for creating insights using big data. Deep learning has emerged as a more accurate and effective technology in a wide range of medical problems such as diagnosis, prediction and intervention. Deep learning is a representation learning method that consists of layers that transform the data non-linearly, thus, revealing hierarchical relationships and structures. In this review we survey deep learning application papers that use structured data, signal and imaging modalities from cardiology. We discuss the advantages and limitations of applying deep learning in cardiology that also apply in medicine in general, while proposing certain directions as the most viable for clinical use.Comment: 27 pages, 2 figures, 10 table

An In-Depth Statistical Review of Retinal Image Processing Models from a Clinical Perspective

The burgeoning field of retinal image processing is critical in facilitating early diagnosis and treatment of retinal diseases, which are amongst the leading causes of vision impairment globally. Despite rapid advancements, existing machine learning models for retinal image processing are characterized by significant limitations, including disparities in pre-processing, segmentation, and classification methodologies, as well as inconsistencies in post-processing operations. These limitations hinder the realization of accurate, reliable, and clinically relevant outcomes. This paper provides an in-depth statistical review of extant machine learning models used in retinal image processing, meticulously comparing them based on their internal operating characteristics and performance levels. By adopting a robust analytical approach, our review delineates the strengths and weaknesses of current models, offering comprehensive insights that are instrumental in guiding future research and development in this domain. Furthermore, this review underscores the potential clinical impacts of these models, highlighting their pivotal role in enhancing diagnostic accuracy, prognostic assessments, and therapeutic interventions for retinal disorders. In conclusion, our work not only bridges the existing knowledge gap in the literature but also paves the way for the evolution of more sophisticated and clinically-aligned retinal image processing models, ultimately contributing to improved patient outcomes and advancements in ophthalmic care

IterMiUnet: A lightweight architecture for automatic blood vessel segmentation

The automatic segmentation of blood vessels in fundus images can help analyze the condition of retinal vasculature, which is crucial for identifying various systemic diseases like hypertension, diabetes, etc. Despite the success of Deep Learning-based models in this segmentation task, most of them are heavily parametrized and thus have limited use in practical applications. This paper proposes IterMiUnet, a new lightweight convolution-based segmentation model that requires significantly fewer parameters and yet delivers performance similar to existing models. The model makes use of the excellent segmentation capabilities of Iternet architecture but overcomes its heavily parametrized nature by incorporating the encoder-decoder structure of MiUnet model within it. Thus, the new model reduces parameters without any compromise with the network's depth, which is necessary to learn abstract hierarchical concepts in deep models. This lightweight segmentation model speeds up training and inference time and is potentially helpful in the medical domain where data is scarce and, therefore, heavily parametrized models tend to overfit. The proposed model was evaluated on three publicly available datasets: DRIVE, STARE, and CHASE-DB1. Further cross-training and inter-rater variability evaluations have also been performed. The proposed model has a lot of potential to be utilized as a tool for the early diagnosis of many diseases