Cómo adaptar un modelo de aprendizaje profundo a un nuevo dominio: el caso de la extracción de relaciones biomédicas

In this article, we study the relation extraction problem from Natural Language Processing (NLP) implementing a domain adaptation setting without external resources. We trained a Deep Learning (DL) model for Relation Extraction (RE), which extracts semantic relations in the biomedical domain. However, can the model be applied to different domains? The model should be adaptable to automatically extract relationships across different domains using the DL network. Completely training DL models in a short time is impractical because the models should quickly adapt to different datasets in several domains without delay. Therefore, adaptation is crucial for intelligent systems, where changing factors and unanticipated perturbations are common. In this study, we present a detailed analysis of the problem, as well as preliminary experimentation, results, and their evaluation.En este trabajo estudiamos el problema de extracción de relaciones del Procesamiento de Lenguaje Natural (PLN). Realizamos una configuración para la adaptación de dominio sin recursos externos. De esta forma, entrenamos un modelo con aprendizaje profundo (DL) para la extracción de relaciones (RE). El modelo permite extraer relaciones semánticas para el dominio biomédico. Sin embargo, ¿El modelo puede ser aplicado a diferentes dominios? El modelo debería adaptarse automáticamente para la extracción de relaciones entre diferentes dominios usando la red de DL. Entrenar completamente modelos DL en una escala de tiempo corta no es práctico, deseamos que los modelos se adapten rápidamente de diferentes conjuntos de datos con varios dominios y sin demora. Así, la adaptación es crucial para los sistemas inteligentes que operan en el mundo real, donde los factores cambiantes y las perturbaciones imprevistas son habituales. En este artículo, presentamos un análisis detallado del problema, una experimentación preliminar, resultados y la discusión acerca de los resultados

Optimizing text mining methods for improving biomedical natural language processing

The overwhelming amount and the increasing rate of publication in the biomedical domain make it difficult for life sciences researchers to acquire and maintain all information that is necessary for their research. Pubmed (the primary citation database for the biomedical literature) currently contains over 21 million article abstracts and more than one million of them were published in 2020 alone. Even though existing article databases provide capable keyword search services, typical everyday-life queries usually return thousands of relevant articles. For instance, a cancer research scientist may need to acquire a complete list of genes that interact with BRCA1 (breast cancer 1) gene. The PubMed keyword search for BRCA1 returns over 16,500 article abstracts, making manual inspection of the retrieved documents impractical. Missing even one of the interacting gene partners in this scenario may jeopardize successful development of a potential new drug or vaccine. Although manually curated databases of biomolecular interactions exist, they are usually not up-to-date and they require notable human effort to maintain. To summarize, new discoveries are constantly being shared within the community via scientific publishing, but unfortunately the probability of missing vital information for research in life sciences is increasing. In response to this problem, the biomedical natural language processing (BioNLP) community of researchers has emerged and strives to assist life sciences researchers by building modern language processing and text mining tools that can be applied at large-scale and scan the whole publicly available literature and extract, classify, and aggregate the information found within, thus keeping life sciences researchers always up-to-date with the recent relevant discoveries and facilitating their research in numerous fields such as molecular biology, biomedical engineering, bioinformatics, genetics engineering and biochemistry. My research has almost exclusively focused on biomedical relation and event extraction tasks. These foundational information extraction tasks deal with automatic detection of biological processes, interactions and relations described in the biomedical literature. Precisely speaking, biomedical relation and event extraction systems can scan through a vast amount of biomedical texts and automatically detect and extract the semantic relations of biomedical named entities (e.g. genes, proteins, chemical compounds, and diseases). The structured outputs of such systems (i.e., the extracted relations or events) can be stored as relational databases or molecular interaction networks which can easily be queried, filtered, analyzed, visualized and integrated with other structured data sources. Extracting biomolecular interactions has always been the primary interest of BioNLP researcher because having knowledge about such interactions is crucially important in various research areas including precision medicine, drug discovery, drug repurposing, hypothesis generation, construction and curation of signaling pathways, and protein function and structure prediction. State-of-the-art relation and event extraction methods are based on supervised machine learning, requiring manually annotated data for training. Manual annotation for the biomedical domain requires domain expertise and it is time-consuming. Hence, having minimal training data for building information extraction systems is a common case in the biomedical domain. This demands development of methods that can make the most out of available training data and this thesis gathers all my research efforts and contributions in that direction. It is worth mentioning that biomedical natural language processing has undergone a revolution since I started my research in this field almost ten years ago. As a member of the BioNLP community, I have witnessed the emergence, improvement– and in some cases, the disappearance–of many methods, each pushing the performance of the best previous method one step further. I can broadly divide the last ten years into three periods. Once I started my research, feature-based methods that relied on heavy feature engineering were dominant and popular. Then, significant advancements in the hardware technology, as well as several breakthroughs in the algorithms and methods enabled machine learning practitioners to seriously utilize artificial neural networks for real-world applications. In this period, convolutional, recurrent, and attention-based neural network models became dominant and superior. Finally, the introduction of transformer-based language representation models such as BERT and GPT impacted the field and resulted in unprecedented performance improvements on many data sets. When reading this thesis, I demand the reader to take into account the course of history and judge the methods and results based on what could have been done in that particular period of the history

A study on developing novel methods for relation extraction

Relation Extraction (RE) is a task of Natural Language Processing (NLP) to detect and classify the relations between two entities. Relation extraction in the biomedical and scientific literature domain is challenging as text can contain multiple pairs of entities in the same instance. During the course of this research, we developed an RE framework (RelEx), which consists of five main RE paradigms: rule-based, machine learning-based, Convolutional Neural Network (CNN)-based, Bidirectional Encoder Representations from Transformers (BERT)-based, and Graph Convolutional Networks (GCNs)-based approaches. RelEx\u27s rule-based approach uses co-location information of the entities to determine whether a relation exists between a selected entity and the other entities. RelEx\u27s machine learning-based approach consists of traditional feature representations into traditional machine learning algorithms. RelEx\u27s CNN-based approach consists of three CNN architectures: Segment-CNN, single-label Sentence-CNN, and multi-label Sentence-CNN. RelEx\u27s BERT-based approach utilizes BERT\u27s contextualized word embeddings into a feed-forward neural network. Finally, RelEx\u27s GCN-based approach consists of two GCN-based architectures: GCN-Vanilla, GCN-BERT. We evaluated variations of these approaches in two different domains across four distinct relation types. Overall our findings showed that the rule-based approach is applicable for data with fewer instances in the training data. In contrast, the CNN-based, BERT-based, and GCN-based approaches perform better with labeled data with many training instances. These approaches automatically identify patterns in the data efficiently, whereas rule-based approaches require expert knowledge to generate rules. The CNN-based, BERT-based approaches capture the local contextual information within a sentence or document by embedding both semantic and syntactic information in a learned representation. However, their ability to capture the long-range dependency global information in a text is limited. GCN-based approaches capture the global association information by performing convolution operations on neighbor nodes in a graph and incorporating information from neighbors. Combining GCN with BERT integrates the local contextual and global association information of the words and generates better representations for the words

Sentence Bag Graph Formulation for Biomedical Distant Supervision Relation Extraction

We introduce a novel graph-based framework for alleviating key challenges in distantly-supervised relation extraction and demonstrate its effectiveness in the challenging and important domain of biomedical data. Specifically, we propose a graph view of sentence bags referring to an entity pair, which enables message-passing based aggregation of information related to the entity pair over the sentence bag. The proposed framework alleviates the common problem of noisy labeling in distantly supervised relation extraction and also effectively incorporates inter-dependencies between sentences within a bag. Extensive experiments on two large-scale biomedical relation datasets and the widely utilized NYT dataset demonstrate that our proposed framework significantly outperforms the state-of-the-art methods for biomedical distant supervision relation extraction while also providing excellent performance for relation extraction in the general text mining domain

Open Information Extraction: A Review of Baseline Techniques, Approaches, and Applications

With the abundant amount of available online and offline text data, there arises a crucial need to extract the relation between phrases and summarize the main content of each document in a few words. For this purpose, there have been many studies recently in Open Information Extraction (OIE). OIE improves upon relation extraction techniques by analyzing relations across different domains and avoids requiring hand-labeling pre-specified relations in sentences. This paper surveys recent approaches of OIE and its applications on Knowledge Graph (KG), text summarization, and Question Answering (QA). Moreover, the paper describes OIE basis methods in relation extraction. It briefly discusses the main approaches and the pros and cons of each method. Finally, it gives an overview about challenges, open issues, and future work opportunities for OIE, relation extraction, and OIE applications.Comment: 15 pages, 9 figure