Does Maturity Signals High Risk and High Return?

The objective of this study is to examine the interaction between firm maturity and firm growth opportunities over risk and its impact on returns. This study uses 135 firms listed in Indonesia Stock Exchange during 2010 to 2016 as sample which gives 945 as total observed data. This study conducts path analysis in term for hypothesis testing and finds that firm maturity has significant role to increase the risk which gives impact on increasing the returns. In context of Indonesian firms, the findings imply that mature firms will have higher risk and higher returns

Ransomware in High-Risk Environments

In today’s modern world, cybercrime is skyrocketing globally, which impacts a variety of organizations and endpoint users. Hackers are using a multitude of approaches and tools, including ransomware threats, to take over targeted systems. These acts of cybercrime lead to huge damages in areas of business, healthcare systems, industry sectors, and other fields. Ransomware is considered as a high risk threat, which is designed to hijack the data. This paper is demonstrating the ransomware types, and how they are evolved from the malware and trojan codes, which is used to attack previous incidents, and explains the most common encryption algorithms such as AES, and RSA, ransomware uses them during infection process in order to produce complex threats. The practical approach for data encryption uses python programming language to show the efficiency of those algorithms in real attacks by executing this section on Ubuntu virtual machine. Furthermore, this paper analyzes programming languages, which is used to build ransomware. An example of ransomware code is being demonstrated in this paper, which is written specifically in C sharp language, and it has been tested out on windows operating system using MS visual studio. So, it is very important to recognize the system vulnerability, which can be very useful to prevent the ransomware. In contrast, this threat might sneak into the system easily, allowing for a ransom to be demanded. Therefore, understanding ransomware anatomy can help us to find a better solution in different situations. Consequently, this paper shows a number of outstanding removal techniques to get rid from ransomware attacks in the system

Christian ministry -- a high-risk calling

Sermon delivered at the convocation of Newman Theological College, 1991. Historical series, no 6. 2 Cor 3:5-6

Faith-Based Institutions and High-Risk Youth

Many of the highest-risk youth in poor communities are not reached by traditional youth programs, but are served by churches and other faith-based institutions that are both well-established and seriously concerned about the welfare of these vulnerable youth and their families. This report, the first in a series from P/PV's National Faith-Based Initiative for High-Risk Youth, provides an initial overview of strategies employed by faith-based institutions in 11 cities, including lessons learned about the distinct contributions of faith-based institutions to the work of civil society, and the challenges of building partnerships between faith-based groups and other institutions -- law enforcement and juvenile justice agencies, foundations and philanthropy, local government and community organizations

Post-Transplant Outcomes in High-Risk Compared with Non-High-Risk Multiple Myeloma: A CIBMTR Analysis.

Conventional cytogenetics and interphase fluorescence in situ hybridization (FISH) identify high-risk multiple myeloma (HRM) populations characterized by poor outcomes. We analyzed these differences among HRM versus non-HRM populations after upfront autologous hematopoietic cell transplantation (autoHCT). Between 2008 and 2012, 715 patients with multiple myeloma identified by FISH and/or cytogenetic data with upfront autoHCT were identified in the Center for International Blood and Marrow Transplant Research database. HRM was defined as del17p, t(4;14), t(14;16), hypodiploidy (-Y) or chromosome 1 p and 1q abnormalities; all others were non-HRM. Among 125 HRM patients (17.5%), induction with bortezomib and immunomodulatory agents (imids) was higher compared with non-HRM (56% versus 43%, P \u3c .001) with similar pretransplant complete response (CR) rates (14% versus 16%, P .1). At day 100 post-transplant, at least a very good partial response was 59% in HRM and 61% in non-HRM (P = .6). More HRM patients received post-transplant therapy with bortezomib and imids (26% versus 12%, P = .004). Three-year post-transplant progression-free (PFS) and overall survival (OS) rates in HRM versus non-HRM were 37% versus 49% (P \u3c .001) and 72% versus 85% (P \u3c .001), respectively. At 3 years, PFS for HRM patients with and without post-transplant therapy was 46% (95% confidence interval [CI], 33 to 59) versus 14% (95% CI, 4 to 29) and in non-HRM patients with and without post-transplant therapy 55% (95% CI, 49 to 62) versus 39% (95% CI, 32 to 47); rates of OS for HRM patients with and without post-transplant therapy were 81% (95% CI, 70 to 90) versus 48% (95% CI, 30 to 65) compared with 88% (95% CI, 84 to 92) and 79% (95% CI, 73 to 85) in non-HRM patients with and without post-transplant therapy, respectively. Among patients receiving post-transplant therapy, there was no difference in OS between HRM and non-HRM (P = .08). In addition to HRM, higher stage, less than a CR pretransplant, lack of post-transplant therapy, and African American race were associated with worse OS. In conclusion, we show HRM patients achieve similar day 100 post-transplant responses compared with non-HRM patients, but these responses are not sustained. Post-transplant therapy appeared to improve the poor outcomes of HRM

Barriers to cervical screening participation in high-risk women

Aim Women aged 25–35 years, for whom cervical cancer is most problematic, are least likely to participate in the cervical screening programme. Therefore, identifying barriers to screening participation in this high-risk group is essential. Subject and methods A sample of 430 women completed an electronic survey of their cervical screening history and answered questions on sociodemographic, behavioural, attitudinal and informational barriers to cervical screening uptake. Logistic regression was used to predict cervical screening non attendance. Results Women with more than 10 sexual partners in their lifetime were more likely, but women from ethnic minorities, less likely to participate in the cervical screening programme. Women unaware of the recommended screening interval were also less likely to be screened, as were women who believed that screening is a test for cancer. Screening was also less likely among women who endorsed the belief that screening in the absence of symptoms is unnecessary. Conclusion These data highlight poor knowledge of the recommended screening interval and purpose of cervical cancer screening in this high-risk group. As such, interventions that target these informational barriers might be most effective for increasing cervical screening uptake in this high-risk group

Adult Social Work and High Risk Domestic Violence Cases

Summary This article focuses on adult social work’s response in England to high-risk domestic violence cases and the role of adult social workers in Multi-Agency Risk and Assessment Conferences. (MARACs). The research was undertaken between 2013-2014 and focused on one city in England and involved the research team attending MARACs, Interviews with 20 adult social workers, 24 MARAC attendees, 14 adult service users at time T1 (including follow up interviews after six months, T2), focus groups with IDVAs and Women’s Aid and an interview with a Women’s Aid service user. Findings The findings suggest that although adult social workers accept the need to be involved in domestic violence cases they are uncertain of what their role is and are confused with the need to operate a parallel domestic violence and adult safeguarding approach, which is further, complicated by issues of mental capacity. MARACS are identified as overburdened, under-represented meetings staffed by committed managers. However, they are in danger of becoming managerial processes neglecting the service users they are meant to protect. Applications The article argues for a re-engagement of adult social workers with domestic violence that has increasingly become over identified with child protection. It also raises the issue whether MARACS remain fit for purpose and whether they still represent the best possible response to multi-agency coordination and practice in domestic violence

Serving High-Risk Youth: Lessons From Research and Programming

Reviews the outcomes of most of the major federal programs designed to help youth connect with the labor force over the past thirty years. Identifies elements that increase the effectiveness of these programs