Enterprise Experience into the Integration of Human-Centered Design and Kanban

he integration of Human-Centered Design (HCD) and Agile Software Development (ASD) promises the development of competitive products comprising a good User Experience (UX). This study has investigated the integration of HCD and Kanban with the aim to gain industrial experiences in a real world context. A case study showed that requirements flow into the development process in a structured manner by adding a design board. To this end, the transparency concerning recurring requirements increased. We contribute to the body of knowledge of software development by providing practical insights into Human-Centered Agile Development (HCAD). On one hand, it is shown that the integration of HCD and Kanban leads to a product with a good UX and makes the development process more human-centered. On the other hand, we conclude that a cross-functional collaboration speeds up product development.Ministerio de Economía y Competitividad TIN2013-46928-C3-3-RMinisterio de Economía y Competitividad TIN2015-71938-RED

Functional expression of TRPV4 channels in human collecting duct cells: implications for secondary hypertension in diabetic nephropathy

Background. The Vanilloid subfamily of transient receptor potential (TRPV) ion channels has been widely implicated in detecting osmotic and mechanical stress. In the current study, we examine the functional expression of TRPV4 channels in cell volume regulation in cells of the human collecting duct. Methods. Western blot analysis, siRNA knockdown, and microfluorimetry were used to assess the expression and function of TRPV4 in mediating Ca2+-dependent mechanical stimulation within a novel system of the human collecting duct (HCD). Results. Native and siRNA knockdown of TRPV4 protein expression was confirmed by western blot analysis. Touch was used as a cell-directed surrogate for osmotic stress. Mechanical stimulation of HCD cells evoked a transient increase in [Ca2+]i that was dependent upon thapsigargin-sensitive store release and Ca2+ influx. At 48 hrs, high glucose and mannitol (25 mM) reduced TRPV4 expression by 54% and 24%, respectively. Similar treatment doubled SGK1 expression. Touch-evoked changes were negated following TRPV4 knockdown. Conclusion. Our data confirm expression of Ca2+-dependent TRPV4 channels in HCD cells and suggest that a loss of expression in response to high glucose attenuates the ability of the collecting duct to exhibit regulatory volume decreases, an effect that may contribute to the pathology of fluid and electrolyte imbalance as observed in diabetic nephropathy

Correlations in the three-dimensional Lyman-alpha forest contaminated by high column density absorbers

Correlations measured in three dimensions in the Lyman-alpha forest are contaminated by the presence of the damping wings of high column density (HCD) absorbing systems of neutral hydrogen (HI; having column densities $N(\mathrm{HI}) > 1.6\times10^{17}\,\mathrm{atoms}\,\mathrm{cm}^{-2}$), which extend significantly beyond the redshift-space location of the absorber. We measure this effect as a function of the column density of the HCD absorbers and redshift by measuring 3D flux power spectra in cosmological hydrodynamical simulations from the Illustris project. Survey pipelines exclude regions containing the largest damping wings. We find that, even after this procedure, there is a scale-dependent correction to the 3D Lyman-alpha forest flux power spectrum from residual contamination. We model this residual using a simple physical model of the HCD absorbers as linearly biased tracers of the matter density distribution, convolved with their Voigt profiles and integrated over the column density distribution function. We recommend the use of this model over existing models used in data analysis, which approximate the damping wings as top-hats and so miss shape information in the extended wings. The simple 'linear Voigt model' is statistically consistent with our simulation results for a mock residual contamination up to small scales ($|k| < 1\,h\,\mathrm{Mpc}^{-1}$). It does not account for the effect of the highest column density absorbers on the smallest scales (e.g., $|k| > 0.4\,h\,\mathrm{Mpc}^{-1}$ for small damped Lyman-alpha absorbers; HCD absorbers with $N(\mathrm{HI}) \sim 10^{21}\,\mathrm{atoms}\,\mathrm{cm}^{-2}$). However, these systems are in any case preferentially removed from survey data. Our model is appropriate for an accurate analysis of the baryon acoustic oscillations feature. It is additionally essential for reconstructing the full shape of the 3D flux power spectrum.Comment: 13 pages, 11 figures. Minor changes to match version published in MNRA

Hidden covariation detection produces faster, not slower, social judgments

In Lewicki’s (1986a) demonstration of Hidden Co-variation Detection (HCD), responses were slower to faces that corresponded with a co-variation encountered previously than to faces with novel co-variations. This slowing contrasts with the typical finding that priming leads to faster responding, and might suggest that HCD is a unique type of implicit process. We extended Lewicki’s (1986a) methodology and showed that participants exposed to nonsalient co-variations between hair length and personality were subsequently faster to respond to faces with those co-variations than to faces without, despite lack of awareness of the critical co-variations. This result confirms that people can detect subtle relationships between features of stimuli and that, as with other types of implicit cognition, this detection facilitates responding.</p

Modeling the human centered design adoption through HCI capability / Rogayah Abdul Majid

The Human Centered Design (HCD) approach rooted in the semi-scientific field of ergonomics was introduced into the software development process to increase the software usability and quality by focusing on the software use and applying human factors/ergonomics and usability knowledge and techniques. In the progress the Human Centered Software Engineering (HCSE) was developed more than a decade ago. HCSE is the framework for integrating the human centered design philosophy and usability engineering into traditional systems development method. Despite its importance, HCD adoption among software practitioners remains low, as reflected in the result of the preliminary study conducted among the Malaysian software development organizations. This research argues that to encourage the HCD adoption among software practitioners a path for HCD adoption needs to be prescribed. This research also argues that an organizational approach and not individual advocates of human-centered design must be used to facilitate the adoption of HCD in systems development. Following this argument of this research embarks on the strategizing of HCD adoption through the development of an adoption model that can inform the readiness of adopting HCD based on technological and organizational capability. The research was carried out in three phases

Recent X-ray hybrid CMOS detector developments and measurements

The Penn State X-ray detector lab, in collaboration with Teledyne Imaging Sensors (TIS), have progressed their efforts to improve soft X-ray Hybrid CMOS detector (HCD) technology on multiple fronts. Having newly acquired a Teledyne cryogenic SIDECAR ASIC for use with HxRG devices, measurements were performed with an H2RG HCD and the cooled SIDECAR. We report new energy resolution and read noise measurements, which show a significant improvement over room temperature SIDECAR operation. Further, in order to meet the demands of future high-throughput and high spatial resolution X-ray observatories, detectors with fast readout and small pixel sizes are being developed. We report on characteristics of new X-ray HCDs with 12.5 micron pitch that include in-pixel CDS circuitry and crosstalk-eliminating CTIA amplifiers. In addition, PSU and TIS are developing a new large-scale array Speedster-EXD device. The original 64 x 64 pixel Speedster-EXD prototype used comparators in each pixel to enable event driven readout with order of magnitude higher effective readout rates, which will now be implemented in a 550 x 550 pixel device. Finally, the detector lab is involved in a sounding rocket mission that is slated to fly in 2018 with an off-plane reflection grating array and an H2RG X-ray HCD. We report on the planned detector configuration for this mission, which will increase the NASA technology readiness level of X-ray HCDs to TRL 9.Comment: 12 pages, 11 figures, appears in Proc. SPIE 2017. error in reported detector thickness, changed from 200 microns to 100 micron

Phosphofructokinase 1 Glycosylation Regulates Cell Growth and Metabolism

Cancer cells must satisfy the metabolic demands of rapid cell growth within a continually changing microenvironment. We demonstrated that the dynamic posttranslational modification of proteins by O-linked β-N-acetylglucosamine (O-GlcNAcylation) is a key metabolic regulator of glucose metabolism. O-GlcNAcylation was induced at serine 529 of phosphofructokinase 1 (PFK1) in response to hypoxia. Glycosylation inhibited PFK1 activity and redirected glucose flux through the pentose phosphate pathway, thereby conferring a selective growth advantage on cancer cells. Blocking glycosylation of PFK1 at serine 529 reduced cancer cell proliferation in vitro and impaired tumor formation in vivo. These studies reveal a previously uncharacterized mechanism for the regulation of metabolic pathways in cancer and a possible target for therapeutic intervention