Solving Factored MDPs with Hybrid State and Action Variables

Efficient representations and solutions for large decision problems with continuous and discrete variables are among the most important challenges faced by the designers of automated decision support systems. In this paper, we describe a novel hybrid factored Markov decision process (MDP) model that allows for a compact representation of these problems, and a new hybrid approximate linear programming (HALP) framework that permits their efficient solutions. The central idea of HALP is to approximate the optimal value function by a linear combination of basis functions and optimize its weights by linear programming. We analyze both theoretical and computational aspects of this approach, and demonstrate its scale-up potential on several hybrid optimization problems

New constraints for heavy axion-like particles from supernovae

We derive new constraints on the coupling of heavy pseudoscalar (axion-like) particles to photons, based on the gamma ray flux expected from the decay of these particles into photons. After being produced in the supernova core, these heavy axion-like particles would escape and a fraction of them would decay into photons before reaching the Earth. We have calculated the expected flux on Earth of these photons from the supernovae SN 1987A and Cassiopeia A and compared our results to data from the Fermi Large Area Telescope. This analysis provides strong constraints on the parameter space for axion-like particles. For a particle mass of 100 MeV, we find that the Peccei-Quinn constant, f_a, must be greater than about 10^{15} GeV. Alternatively, for fa=10^{12} GeV, we exclude the mass region between approximately 100 eV and 1 GeV.Comment: 14 pages, 4 figures. Version published in JCAP. Major changes in the exposition. Added a figure. Added appendix. Minor changes in the results. Some changes in the bibliograph

Geometeric Letters

STRAIGHT LINE LETTERS ONLY (AEFHIKLMNTVWXYZ) Longest word made from straight line letters: possibly METHYLHEXANEAMINE (Dorland\u27s Medical Dictionary). (ZENZIZENZIZENZIc and sym-METHYLETHYLETHYLENE have straight line strings of 15, 19 letters.) Longest straight line letter heterogram: several, including WILKHAVEN and WYKHAMITE, have 9 letter

Il sottofondo culturale del De anima di Cassiodoro.

Sin resume

Self-assembling peptide-enriched electrospun polycaprolactone scaffolds promote the h-osteoblast adhesion and modulate differentiation-associated gene expression

Electrospun polycaprolactone (PCL) is able to support the adhesion and growth of h-osteoblasts and to delay their degradation rate to a greater extent with respect to other polyesters. The drawbacks linked to its employment in regenerative medicine arise fromits hydrophobic nature and the lack of biochemical signals linked to it. This work reports on the attempt to add five different self-assembling (SA) peptides to PCL solutions before electrospinning. The hybrid scaffolds obtained had regular fibers (SEM analysis) whose diameters were similar to those of the extracellularmatrix, more stable hydrophilic (contact angle measurement) surfaces, and anamorphous phase constrained by peptides (DSC analysis). They appeared to have a notable capacity to promote the h-osteoblast adhesion and differentiation process by increasing the gene expression of alkaline phosphatase, bone sialoprotein, and osteopontin. Adding an Arg-Gly-Asp (RGD) motif to a self-assembling sequence was found to enhance cell adhesion, while the same motif condensed with a scrambled sequence did not, indicating that there is a cooperative effect between RGD and 3D architecture created by the self-assembling peptides. The study demonstrates that self-assembling peptide scaffolds are still able to promote beneficial effects on h-osteoblasts even after they have been included in electrospun polycaprolactone. The possibility of linking biochemical messages to self-assembling peptides could lead the way to a 3D decoration of fibrous scaffolds