Characteristic of partition-circuit matroid through approximation number

Rough set theory is a useful tool to deal with uncertain, granular and incomplete knowledge in information systems. And it is based on equivalence relations or partitions. Matroid theory is a structure that generalizes linear independence in vector spaces, and has a variety of applications in many fields. In this paper, we propose a new type of matroids, namely, partition-circuit matroids, which are induced by partitions. Firstly, a partition satisfies circuit axioms in matroid theory, then it can induce a matroid which is called a partition-circuit matroid. A partition and an equivalence relation on the same universe are one-to-one corresponding, then some characteristics of partition-circuit matroids are studied through rough sets. Secondly, similar to the upper approximation number which is proposed by Wang and Zhu, we define the lower approximation number. Some characteristics of partition-circuit matroids and the dual matroids of them are investigated through the lower approximation number and the upper approximation number.Comment: 12 page

Multiscale modeling of granular flows with application to crowd dynamics

In this paper a new multiscale modeling technique is proposed. It relies on a recently introduced measure-theoretic approach, which allows to manage the microscopic and the macroscopic scale under a unique framework. In the resulting coupled model the two scales coexist and share information. This allows to perform numerical simulations in which the trajectories and the density of the particles affect each other. Crowd dynamics is the motivating application throughout the paper.Comment: 30 pages, 9 figure

Identification of control targets in Boolean molecular network models via computational algebra

Motivation: Many problems in biomedicine and other areas of the life sciences can be characterized as control problems, with the goal of finding strategies to change a disease or otherwise undesirable state of a biological system into another, more desirable, state through an intervention, such as a drug or other therapeutic treatment. The identification of such strategies is typically based on a mathematical model of the process to be altered through targeted control inputs. This paper focuses on processes at the molecular level that determine the state of an individual cell, involving signaling or gene regulation. The mathematical model type considered is that of Boolean networks. The potential control targets can be represented by a set of nodes and edges that can be manipulated to produce a desired effect on the system. Experimentally, node manipulation requires technology to completely repress or fully activate a particular gene product while edge manipulations only require a drug that inactivates the interaction between two gene products. Results: This paper presents a method for the identification of potential intervention targets in Boolean molecular network models using algebraic techniques. The approach exploits an algebraic representation of Boolean networks to encode the control candidates in the network wiring diagram as the solutions of a system of polynomials equations, and then uses computational algebra techniques to find such controllers. The control methods in this paper are validated through the identification of combinatorial interventions in the signaling pathways of previously reported control targets in two well studied systems, a p53-mdm2 network and a blood T cell lymphocyte granular leukemia survival signaling network.Comment: 12 pages, 4 figures, 2 table

Multiscale modeling of granular flows with application to crowd dynamics

In this paper a new multiscale modeling technique is proposed. It relies on a recently introduced measure-theoretic approach, which allows to manage the microscopic and the macroscopic scale under a unique framework. In the resulting coupled model the two scales coexist and share information. This allows to perform numerical simulations in which the trajectories and the density of the particles affect each other. Crowd dynamics is the motivating application throughout the paper.Comment: 30 pages, 9 figure

Algebraic, Topological, and Mereological Foundations of Existential Granules

In this research, new concepts of existential granules that determine themselves are invented, and are characterized from algebraic, topological, and mereological perspectives. Existential granules are those that determine themselves initially, and interact with their environment subsequently. Examples of the concept, such as those of granular balls, though inadequately defined, algorithmically established, and insufficiently theorized in earlier works by others, are already used in applications of rough sets and soft computing. It is shown that they fit into multiple theoretical frameworks (axiomatic, adaptive, and others) of granular computing. The characterization is intended for algorithm development, application to classification problems and possible mathematical foundations of generalizations of the approach. Additionally, many open problems are posed and directions provided.Comment: 15 Pages. Accepted IJCRS 202