7,554 research outputs found

    The Globalization of Artificial Intelligence: African Imaginaries of Technoscientific Futures

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    Imaginaries of artificial intelligence (AI) have transcended geographies of the Global North and become increasingly entangled with narratives of economic growth, progress, and modernity in Africa. This raises several issues such as the entanglement of AI with global technoscientific capitalism and its impact on the dissemination of AI in Africa. The lack of African perspectives on the development of AI exacerbates concerns of raciality and inclusion in the scientific research, circulation, and adoption of AI. My argument in this dissertation is that innovation in AI, in both its sociotechnical imaginaries and political economies, excludes marginalized countries, nations and communities in ways that not only bar their participation in the reception of AI, but also as being part and parcel of its creation. Underpinned by decolonial thinking, and perspectives from science and technology studies and African studies, this dissertation looks at how AI is reconfiguring the debate about development and modernization in Africa and the implications for local sociotechnical practices of AI innovation and governance. I examined AI in international development and industry across Kenya, Ghana, and Nigeria, by tracing Canada’s AI4D Africa program and following AI start-ups at AfriLabs. I used multi-sited case studies and discourse analysis to examine the data collected from interviews, participant observations, and documents. In the empirical chapters, I first examine how local actors understand the notion of decolonizing AI and show that it has become a sociotechnical imaginary. I then investigate the political economy of AI in Africa and argue that despite Western efforts to integrate the African AI ecosystem globally, the AI epistemic communities in the continent continue to be excluded from dominant AI innovation spaces. Finally, I examine the emergence of a Pan-African AI imaginary and argue that AI governance can be understood as a state-building experiment in post-colonial Africa. The main issue at stake is that the lack of African perspectives in AI leads to negative impacts on innovation and limits the fair distribution of the benefits of AI across nations, countries, and communities, while at the same time excludes globally marginalized epistemic communities from the imagination and creation of AI

    Multi-dimensional omics approaches to dissect natural immune control mechanisms associated with RNA virus infections

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    In recent decades, global health has been challenged by emerging and re-emerging viruses such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV2), human immunodeficiency viruses (HIV-1), and Crimean–Congo hemorrhagic fever virus (CCHFV). Studies have shown dysregulations in the host metabolic processes against SARS-CoV2 and HIV-1 infections, and the research on CCHFV infection is still in the infant stage. Hence, understanding the host metabolic re-programming on the reaction level in infectious disease has therapeutic importance. The thesis uses systems biology methods to investigate the host metabolic alterations in response to SARS-CoV2, HIV-1, and CCHFV infections. The three distinct viruses induce distinct effects on human metabolism that, nevertheless, show some commonalities. We have identified alterations in various immune cell types in patients during the infections of the three viruses. Further, differential expression analysis identified that COVID-19 causes disruptions in pathways related to antiviral response and metabolism (fructose mannose metabolism, oxidative phosphorylation (OXPHOS), and pentose phosphate pathway). Up-regulation of OXPHOS and ROS pathways with most changes in OXPHOS complexes I, III, and IV were identified in people living with HIV on treatment (PLWHART). The acute phase of CCHFV infection is found to be linked with OXPHOS, glycolysis, N-glycan biosynthesis, and NOD-like receptor signaling pathways. The dynamic nature of the metabolic process and adaptive immune response in CCHFV-pathogenesis are also observed. Further, we have identified different metabolic flux in reactions transporting TCA cycle intermediates from the cytosol to mitochondria in COVID-19 patients. Genes such as monocarboxylate transporter (SLC16A6) and nucleoside transporter (SLC29A1) and metabolites such as α-ketoglutarate, succinate, and malate were found to be linked with COVID-19 disease response. Metabolic reactions associated with amino acid, carbohydrate, and energy metabolism pathways and various transporter reactions were observed to be uniquely disrupted in PLWHART along with increased production of αketoglutarate (αKG) and ATP molecules. Changes in essential (leucine and threonine) and non-essential (arginine, alanine, and glutamine) amino acid transport were found to be caused by acute CCHFV infection. The altered flux of reactions involving TCA cycle compounds such as pyruvate, isocitrate, and alpha-ketoglutarate was also observed in CCHFV infection. The research described in the thesis displayed dysregulations in similar metabolic processes against the three viral Infections. But further downstream analysis unveiled unique alterations in several metabolic reactions specific to each virus in the same metabolic pathways showing the importance of increasing the resolution of knowledge about host metabolism in infectious diseases

    Cyber Conflict and Just War Theory

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    Endogenous measures for contextualising large-scale social phenomena: a corpus-based method for mediated public discourse

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    This work presents an interdisciplinary methodology for developing endogenous measures of group membership through analysis of pervasive linguistic patterns in public discourse. Focusing on political discourse, this work critiques the conventional approach to the study of political participation, which is premised on decontextualised, exogenous measures to characterise groups. Considering the theoretical and empirical weaknesses of decontextualised approaches to large-scale social phenomena, this work suggests that contextualisation using endogenous measures might provide a complementary perspective to mitigate such weaknesses. This work develops a sociomaterial perspective on political participation in mediated discourse as affiliatory action performed through language. While the affiliatory function of language is often performed consciously (such as statements of identity), this work is concerned with unconscious features (such as patterns in lexis and grammar). This work argues that pervasive patterns in such features that emerge through socialisation are resistant to change and manipulation, and thus might serve as endogenous measures of sociopolitical contexts, and thus of groups. In terms of method, the work takes a corpus-based approach to the analysis of data from the Twitter messaging service whereby patterns in users’ speech are examined statistically in order to trace potential community membership. The method is applied in the US state of Michigan during the second half of 2018—6 November having been the date of midterm (i.e. non-Presidential) elections in the United States. The corpus is assembled from the original posts of 5,889 users, who are nominally geolocalised to 417 municipalities. These users are clustered according to pervasive language features. Comparing the linguistic clusters according to the municipalities they represent finds that there are regular sociodemographic differentials across clusters. This is understood as an indication of social structure, suggesting that endogenous measures derived from pervasive patterns in language may indeed offer a complementary, contextualised perspective on large-scale social phenomena

    2023-2024 Boise State University Undergraduate Catalog

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    This catalog is primarily for and directed at students. However, it serves many audiences, such as high school counselors, academic advisors, and the public. In this catalog you will find an overview of Boise State University and information on admission, registration, grades, tuition and fees, financial aid, housing, student services, and other important policies and procedures. However, most of this catalog is devoted to describing the various programs and courses offered at Boise State

    Characterizing the Neuropsychological profile and Examining the Role of Cognitive Reserve in Pediatric-Onset Multiple Sclerosis Using a Computerized Battery

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    Multiple sclerosis (MS) is a chronic demyelinating and degenerative condition of the central nervous system. While the majority of affected individuals show their first symptoms between the ages of 25-35 years, 3-5% of people have a pediatric-onset (POMS) of the disease, with a first attack occurring prior to age at 18. POMS leads to a range of physical and cognitive symptoms that impact everyday functioning and development, however, further research is needed to understand the cognitive profile and predict outcomes. The overall objective of this program of research was to better understand processes facilitating protection against the cognitive presentation of neuropathology in POMS, with a specific focus on cognitive reserve (CR) and its domain-specificity. Areas of deficit in POMS were first clarified, with delineation of dysfunction in speed and accuracy across cognitive domains using a computerized neurocognitive battery. In Study 1, we found that deficits in working memory, attention/inhibition, visuospatial processing, verbal recognition memory and verbal reasoning exist separately from and in addition to slowed speed of processing in individuals affected by POMS. Furthermore, we found that individuals with POMS are afforded some protection by CR (as estimated by parental education) in Study 2, however, these affects appeared weaker than what has been observed in adults. CR effects were strongest for tasks of executive functioning, where patients demonstrated greatest deficit relative to controls, and were not observed for tasks of information processing speed, potentially owing to differential availability of compensatory strategies in these networks. These findings highlight differences in vulnerability to cognitive dysfunction in individuals with POMS, given impacts of the disease on developing functions and reserves. We propose that cognitive screening should be expanded beyond assessment of simple processing speed to identify a greater proportion of youth affected by the cognitive sequelae of MS. While the mechanisms contributing to the development of CR remain to be elucidated, engagement in a range of physically and cognitively enriching activities, as well as a focus on mental health may be helpful towards better cognitive outcomes for youth with POMS. Further research is needed with direct comparison to adults with MS to understand how the developmental context influences the profile of cognitive deficits and role of protective factors in POMS

    Modified Theories of Gravity and Cosmological Applications

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    This reprint focuses on recent aspects of gravitational theory and cosmology. It contains subjects of particular interest for modified gravity theories and applications to cosmology, special attention is given to Einstein–Gauss–Bonnet, f(R)-gravity, anisotropic inflation, extra dimension theories of gravity, black holes, dark energy, Palatini gravity, anisotropic spacetime, Einstein–Finsler gravity, off-diagonal cosmological solutions, Hawking-temperature and scalar-tensor-vector theories

    Late-bound code generation

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    Each time a function or method is invoked during the execution of a program, a stream of instructions is issued to some underlying hardware platform. But exactly what underlying hardware, and which instructions, is usually left implicit. However in certain situations it becomes important to control these decisions. For example, particular problems can only be solved in real-time when scheduled on specialised accelerators, such as graphics coprocessors or computing clusters. We introduce a novel operator for hygienically reifying the behaviour of a runtime function instance as a syntactic fragment, in a language which may in general differ from the source function definition. Translation and optimisation are performed by recursively invoked, dynamically dispatched code generators. Side-effecting operations are permitted, and their ordering is preserved. We compare our operator with other techniques for pragmatic control, observing that: the use of our operator supports lifting arbitrary mutable objects, and neither requires rewriting sections of the source program in a multi-level language, nor interferes with the interface to individual software components. Due to its lack of interference at the abstraction level at which software is composed, we believe that our approach poses a significantly lower barrier to practical adoption than current methods. The practical efficacy of our operator is demonstrated by using it to offload the user interface rendering of a smartphone application to an FPGA coprocessor, including both statically and procedurally defined user interface components. The generated pipeline is an application-specific, statically scheduled processor-per-primitive rendering pipeline, suitable for place-and-route style optimisation. To demonstrate the compatibility of our operator with existing languages, we show how it may be defined within the Python programming language. We introduce a transformation for weakening mutable to immutable named bindings, termed let-weakening, to solve the problem of propagating information pertaining to named variables between modular code generating units.Open Acces

    Reframing Construction Labour Productivity in a Colonisation Context: The West Bank as an Example

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    This thesis explores the under-researched topic of defining construction labour productivity and the factors impacting it in the context of a small, volatile and dependent economy of the West Bank. The aim is to identify the impact of particular social, economic and political constraints on structural and agency factors affecting the construction sector's productivity using case studies from the West Bank. Labour productivity is studied from a broad perspective, adding political and economic conditions to reframe and evaluate the term and its determinants in the context of high uncertainty, political instability and complex geography. 'Labour productivity' comes to represent the production interplay between agency and structural factors, and construction labour is treated as complementary to the machine rather than as an extension of it. The theoretical framework is developed based on Giddens' Structuration Theory, mainly the reconciliation of the multi-layers structure and agency determinants impacting construction labour productivity in the context of colonisation. The study's philosophy validates the use of mixed methods methodology, merging positivism and constructivism under the canopy of pragmatism. Quantitative and qualitative data have been collected, with the quantitative part consisting primarily of comprehensive survey data from the PCBS and the qualitative of purposive semi-structured interviews with decision makers at macro and meso levels plus analysis of multiple case studies. The results reveal that the controversy about using hourly wage as an indication of construction productivity is resolved by including labour characteristics and context-specific variables in the model. The construction sector in Israel depends on skilled blue-collar employees from the West Bank rather than unskilled ones, with a higher rate of labour mobility for those from rural areas to Israeli construction markets than from other locations, leading to skill shortages in the West Bank. The construction labour process in the West Bank also rests on low levels of vocational education and training and a high risk of accidents due to meagre experience, lack of training and improper application of health and safety regulations. Finally, Israeli control of movement within the West Bank and the outlets to international markets impacts on labour productivity by imposing restrictions on importing and transporting construction materials and the internal mobility of workers. The research contributes to knowledge through its originality and generalisation by mapping the complexity of social factors and providing a definition of construction productivity appropriate to colonisation
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