Label-driven weakly-supervised learning for multimodal deformable image registration

Spatially aligning medical images from different modalities remains a challenging task, especially for intraoperative applications that require fast and robust algorithms. We propose a weakly-supervised, label-driven formulation for learning 3D voxel correspondence from higher-level label correspondence, thereby bypassing classical intensity-based image similarity measures. During training, a convolutional neural network is optimised by outputting a dense displacement field (DDF) that warps a set of available anatomical labels from the moving image to match their corresponding counterparts in the fixed image. These label pairs, including solid organs, ducts, vessels, point landmarks and other ad hoc structures, are only required at training time and can be spatially aligned by minimising a cross-entropy function of the warped moving label and the fixed label. During inference, the trained network takes a new image pair to predict an optimal DDF, resulting in a fully-automatic, label-free, real-time and deformable registration. For interventional applications where large global transformation prevails, we also propose a neural network architecture to jointly optimise the global- and local displacements. Experiment results are presented based on cross-validating registrations of 111 pairs of T2-weighted magnetic resonance images and 3D transrectal ultrasound images from prostate cancer patients with a total of over 4000 anatomical labels, yielding a median target registration error of 4.2 mm on landmark centroids and a median Dice of 0.88 on prostate glands.Comment: Accepted to ISBI 201

Adversarial Sensor Attack on LiDAR-based Perception in Autonomous Driving

In Autonomous Vehicles (AVs), one fundamental pillar is perception, which leverages sensors like cameras and LiDARs (Light Detection and Ranging) to understand the driving environment. Due to its direct impact on road safety, multiple prior efforts have been made to study its the security of perception systems. In contrast to prior work that concentrates on camera-based perception, in this work we perform the first security study of LiDAR-based perception in AV settings, which is highly important but unexplored. We consider LiDAR spoofing attacks as the threat model and set the attack goal as spoofing obstacles close to the front of a victim AV. We find that blindly applying LiDAR spoofing is insufficient to achieve this goal due to the machine learning-based object detection process. Thus, we then explore the possibility of strategically controlling the spoofed attack to fool the machine learning model. We formulate this task as an optimization problem and design modeling methods for the input perturbation function and the objective function. We also identify the inherent limitations of directly solving the problem using optimization and design an algorithm that combines optimization and global sampling, which improves the attack success rates to around 75%. As a case study to understand the attack impact at the AV driving decision level, we construct and evaluate two attack scenarios that may damage road safety and mobility. We also discuss defense directions at the AV system, sensor, and machine learning model levels.Comment: Accepted at the ACM Conference on Computer and Communications Security (CCS), 201

An unsupervised approach to Geographical Knowledge Discovery using street level and street network images

Recent researches have shown the increasing use of machine learn-ing methods in geography and urban analytics, primarily to extract features and patterns from spatial and temporal data using a supervised approach. Researches integrating geographical processes in machine learning models and the use of unsupervised approacheson geographical data for knowledge discovery had been sparse. This research contributes to the ladder, where we show how latent variables learned from unsupervised learning methods on urbanimages can be used for geographic knowledge discovery. In particular, we propose a simple approach called Convolutional-PCA(ConvPCA) which are applied on both street level and street network images to find a set of uncorrelated and ordered visual latentcomponents. The approach allows for meaningful explanations using a combination of geographical and generative visualisations to explore the latent space, and to show how the learned representation can be used to predict urban characteristics such as streetquality and street network attributes. The research also finds that the visual components from the ConvPCA model achieves similaraccuracy when compared to less interpretable dimension reduction techniques.Comment: SigSpatial 2019 GeoA