2,848 research outputs found
Chronic helminth infection burden differentially affects haematopoietic cell development while ageing selectively impairs adaptive responses to infection
Throughout the lifespan of an individual, the immune system undergoes complex changes while facing novel and chronic infections. Helminths, which infect over one billion people and impose heavy livestock productivity losses, typically cause chronic infections by avoiding and suppressing host immunity. Yet, how age affects immune responses to lifelong parasitic infection is poorly understood. To disentangle the processes involved, we employed supervised statistical learning techniques to identify which factors among haematopoietic stem and progenitor cells (HSPC), and both innate and adaptive responses regulate parasite burdens and how they are affected by host age. Older mice harboured greater numbers of the parasites’ offspring than younger mice. Protective immune responses that did not vary with age were dominated by HSPC, while ageing specifically eroded adaptive immunity, with reduced numbers of naïve T cells, poor T cell responsiveness to parasites, and impaired antibody production. We identified immune factors consistent with previously-reported immune responses to helminths, and also revealed novel interactions between helminths and HSPC maturation. Our approach thus allowed disentangling the concurrent effects of ageing and infection across the full maturation cycle of the immune response and highlights the potential of such approaches to improve understanding of the immune system within the whole organism
Checking and Enforcing Security through Opacity in Healthcare Applications
The Internet of Things (IoT) is a paradigm that can tremendously
revolutionize health care thus benefiting both hospitals, doctors and patients.
In this context, protecting the IoT in health care against interference,
including service attacks and malwares, is challenging. Opacity is a
confidentiality property capturing a system's ability to keep a subset of its
behavior hidden from passive observers. In this work, we seek to introduce an
IoT-based heart attack detection system, that could be life-saving for patients
without risking their need for privacy through the verification and enforcement
of opacity. Our main contributions are the use of a tool to verify opacity in
three of its forms, so as to detect privacy leaks in our system. Furthermore,
we develop an efficient, Symbolic Observation Graph (SOG)-based algorithm for
enforcing opacity
Tetramerisation of a frustrated spin-1/2 chain
We investigate a model of a frustrated spin-1/2 Heisenberg chain coupled to
adiabatic phonons with a general form of magnetoelastic coupling. For large
enough frustration and lattice coupling a new tetramerised phase with three
different bond lengths is found. We argue that the zig-zag spin-1/2 chain
LiVO might be a good candidate to observe such a phase
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