5,919 research outputs found
Hybrid performance modelling of opportunistic networks
We demonstrate the modelling of opportunistic networks using the process
algebra stochastic HYPE. Network traffic is modelled as continuous flows,
contact between nodes in the network is modelled stochastically, and
instantaneous decisions are modelled as discrete events. Our model describes a
network of stationary video sensors with a mobile ferry which collects data
from the sensors and delivers it to the base station. We consider different
mobility models and different buffer sizes for the ferries. This case study
illustrates the flexibility and expressive power of stochastic HYPE. We also
discuss the software that enables us to describe stochastic HYPE models and
simulate them.Comment: In Proceedings QAPL 2012, arXiv:1207.055
COMPUTER SIMULATION AND COMPUTABILITY OF BIOLOGICAL SYSTEMS
The ability to simulate a biological organism by employing a computer is related to the
ability of the computer to calculate the behavior of such a dynamical system, or the "computability" of the system.* However, the two questions of computability and simulation are not equivalent. Since the question of computability can be given a precise answer in terms of recursive functions, automata theory and dynamical systems, it will be appropriate to consider it first. The more elusive question of adequate simulation of biological systems by a computer will be then addressed and a possible connection between the two answers given will be considered. A conjecture is formulated that suggests the possibility of employing an algebraic-topological, "quantum" computer (Baianu, 1971b)
for analogous and symbolic simulations of biological systems that may include chaotic processes that are not, in genral, either recursively or digitally computable. Depending on the biological network being modelled, such as the Human Genome/Cell Interactome or a trillion-cell Cognitive Neural Network system, the appropriate logical structure for such simulations might be either the Quantum MV-Logic (QMV) discussed in recent publications (Chiara, 2004, and references cited therein)or Lukasiewicz Logic Algebras that were shown to be isomorphic to MV-logic algebras (Georgescu et al, 2001)
Categorical Ontology of Complex Systems, Meta-Systems and Theory of Levels: The Emergence of Life, Human Consciousness and Society
Single cell interactomics in simpler organisms, as well as somatic cell interactomics in multicellular organisms, involve biomolecular interactions in complex signalling pathways that were recently represented in modular terms by quantum automata with ‘reversible behavior’ representing normal cell cycling and division. Other implications of such quantum automata, modular modeling of signaling pathways and cell differentiation during development are in the fields of neural plasticity and brain development leading to quantum-weave dynamic patterns and specific molecular processes underlying extensive memory, learning, anticipation mechanisms and the emergence of human consciousness during the early brain development in children. Cell interactomics is here represented for the first time as a mixture of ‘classical’ states that determine molecular dynamics subject to Boltzmann statistics and ‘steady-state’, metabolic (multi-stable) manifolds, together with ‘configuration’ spaces of metastable quantum states emerging from complex quantum dynamics of interacting networks of biomolecules, such as proteins and nucleic acids that are now collectively defined as quantum interactomics. On the other hand, the time dependent evolution over several generations of cancer cells --that are generally known to undergo frequent and extensive genetic mutations and, indeed, suffer genomic transformations at the chromosome level (such as extensive chromosomal aberrations found in many colon cancers)-- cannot be correctly represented in the ‘standard’ terms of quantum automaton modules, as the normal somatic cells can. This significant difference at the cancer cell genomic level is therefore reflected in major changes in cancer cell interactomics often from one cancer cell ‘cycle’ to the next, and thus it requires substantial changes in the modeling strategies, mathematical tools and experimental designs aimed at understanding cancer mechanisms. Novel solutions to this important problem in carcinogenesis are proposed and experimental validation procedures are suggested. From a medical research and clinical standpoint, this approach has important consequences for addressing and preventing the development of cancer resistance to medical therapy in ongoing clinical trials involving stage III cancer patients, as well as improving the designs of future clinical trials for cancer treatments.\ud
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KEYWORDS: Emergence of Life and Human Consciousness;\ud
Proteomics; Artificial Intelligence; Complex Systems Dynamics; Quantum Automata models and Quantum Interactomics; quantum-weave dynamic patterns underlying human consciousness; specific molecular processes underlying extensive memory, learning, anticipation mechanisms and human consciousness; emergence of human consciousness during the early brain development in children; Cancer cell ‘cycling’; interacting networks of proteins and nucleic acids; genetic mutations and chromosomal aberrations in cancers, such as colon cancer; development of cancer resistance to therapy; ongoing clinical trials involving stage III cancer patients’ possible improvements of the designs for future clinical trials and cancer treatments. \ud
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Web Services: A Process Algebra Approach
It is now well-admitted that formal methods are helpful for many issues
raised in the Web service area. In this paper we present a framework for the
design and verification of WSs using process algebras and their tools. We
define a two-way mapping between abstract specifications written using these
calculi and executable Web services written in BPEL4WS. Several choices are
available: design and correct errors in BPEL4WS, using process algebra
verification tools, or design and correct in process algebra and automatically
obtaining the corresponding BPEL4WS code. The approaches can be combined.
Process algebra are not useful only for temporal logic verification: we remark
the use of simulation/bisimulation both for verification and for the
hierarchical refinement design method. It is worth noting that our approach
allows the use of any process algebra depending on the needs of the user at
different levels (expressiveness, existence of reasoning tools, user
expertise)
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