Statistical performance analysis of a fast super-resolution technique using noisy translations

It is well known that the registration process is a key step for super-resolution reconstruction. In this work, we propose to use a piezoelectric system that is easily adaptable on all microscopes and telescopes for controlling accurately their motion (down to nanometers) and therefore acquiring multiple images of the same scene at different controlled positions. Then a fast super-resolution algorithm \cite{eh01} can be used for efficient super-resolution reconstruction. In this case, the optimal use of $r^2$ images for a resolution enhancement factor $r$ is generally not enough to obtain satisfying results due to the random inaccuracy of the positioning system. Thus we propose to take several images around each reference position. We study the error produced by the super-resolution algorithm due to spatial uncertainty as a function of the number of images per position. We obtain a lower bound on the number of images that is necessary to ensure a given error upper bound with probability higher than some desired confidence level.Comment: 15 pages, submitte

Adversarial training with cycle consistency for unsupervised super-resolution in endomicroscopy

In recent years, endomicroscopy has become increasingly used for diagnostic purposes and interventional guidance. It can provide intraoperative aids for real-time tissue characterization and can help to perform visual investigations aimed for example to discover epithelial cancers. Due to physical constraints on the acquisition process, endomicroscopy images, still today have a low number of informative pixels which hampers their quality. Post-processing techniques, such as Super-Resolution (SR), are a potential solution to increase the quality of these images. SR techniques are often supervised, requiring aligned pairs of low-resolution (LR) and high-resolution (HR) images patches to train a model. However, in our domain, the lack of HR images hinders the collection of such pairs and makes supervised training unsuitable. For this reason, we propose an unsupervised SR framework based on an adversarial deep neural network with a physically-inspired cycle consistency, designed to impose some acquisition properties on the super-resolved images. Our framework can exploit HR images, regardless of the domain where they are coming from, to transfer the quality of the HR images to the initial LR images. This property can be particularly useful in all situations where pairs of LR/HR are not available during the training. Our quantitative analysis, validated using a database of 238 endomicroscopy video sequences from 143 patients, shows the ability of the pipeline to produce convincing super-resolved images. A Mean Opinion Score (MOS) study also confirms this quantitative image quality assessment.Comment: Accepted for publication on Medical Image Analysis journa