Methamphetamine detection using nanoparticle-based biosensors: A comprehensive review

(c) The Author/sDrug abuse is a global issue, requiring diverse techniques for recognition of drug of interest. One such illicit drug that is abused worldwide is Methamphetamine (METH). It is an addictive and illicit substance that severely affects the central nervous system. Similar to many other illicit substances, recognition of METH in biological fluids and in more diverse matrices such as wastewater, is a topic of great interest to the government and law enforcement agencies. With the rise of nanotechnology that relies on exploiting the properties of certain materials at a scale down to their nanometer range in conjunction with aptamers, molecularly imprinted polymers as well as antibodies have gained much attention over the last decade. The scope and appositeness of nanomaterials have significant characteristics that are highly suitable for recognition of illicit chemical compounds such as METH. This comprehensive review focuses on the detection of METH using nanoparticles in real world samples such as biological fluids and wastewater, while discussing varieties of materials used as nanoparticles and that aid in its recognition. It also offers insights into future opportunities and challenges that come with the use of nanotechnology in sensing applications.fals

Fabrication of Au Nanorods by the Oblique Angle Deposition Process for Trace Detection of Methamphetamine with Surface-Enhanced Raman Scattering

Oblique angle deposition (OAD) is a simple, low cost, effective, and maskless nanofabrication process. It can offer a reliable method for the mass fabrication of uniform metal nanorods which can be used as the surface-enhanced Raman scattering (SERS) substrate with an excellent enhancing performance. Up to now, Ag nanorods SERS substrates have been extensively studied. However, Ag is chemically active and easy to oxidize under atmospheric conditions. Comparatively, Au is chemically stable and has better biocompatibility than Ag. In this paper, we in detail, studied the electromechanical (EM) field distribution simulation, fabrication, and application of Au nanorods (AuNRs) on trace detection of methamphetamine. According to the finite-difference time-domain (FDTD) calculation results, the maximum EM intensity can be obtained with the length of AuNRs to be 800 nm and the tilting angle of AuNRs to be 71° respectively. The aligned Au nanorod array substrate was fabricated by the OAD process. The two key process parameters, deposition angle, and deposition rate were optimized by experiments, which were 86° and 2 Å/s, respectively. Using 1,2-bis (4-pyridyl) ethylene (BPE) as the probe molecule, the limit of detection (LOD) was characterized to be 10−11 M. The AuNRs were also used to detect methamphetamine. The LOD can be down to M (i.e., 14.92 pg/ml), which meet the requirements of the on-site rapid detection of the methamphetamine in human urine (500 ng/ml)