CANDLE: Decomposing Conditional and Conjunctive Queries for Task-Oriented Dialogue Systems

Domain-specific dialogue systems generally determine user intents by relying on sentence-level classifiers which mainly focus on single action sentences. Such classifiers are not designed to effectively handle complex queries composed of conditional and sequential clauses that represent multiple actions. We attempt to decompose such queries into smaller single-action sub-queries that are reasonable for intent classifiers to understand in a dialogue pipeline. We release CANDLE (Conditional & AND type Expressions), a dataset consisting of 3124 utterances manually tagged with conditional and sequential labels and demonstrates this decomposition by training two baseline taggers

Knowledge-based Biomedical Data Science 2019

Knowledge-based biomedical data science (KBDS) involves the design and implementation of computer systems that act as if they knew about biomedicine. Such systems depend on formally represented knowledge in computer systems, often in the form of knowledge graphs. Here we survey the progress in the last year in systems that use formally represented knowledge to address data science problems in both clinical and biological domains, as well as on approaches for creating knowledge graphs. Major themes include the relationships between knowledge graphs and machine learning, the use of natural language processing, and the expansion of knowledge-based approaches to novel domains, such as Chinese Traditional Medicine and biodiversity.Comment: Manuscript 43 pages with 3 tables; Supplemental material 43 pages with 3 table

Enhancing Usability and Explainability of Data Systems

The recent growth of data science expanded its reach to an ever-growing user base of nonexperts, increasing the need for usability, understandability, and explainability in these systems. Enhancing usability makes data systems accessible to people with different skills and backgrounds alike, leading to democratization of data systems. Furthermore, proper understanding of data and data-driven systems is necessary for the users to trust the function of the systems that learn from data. Finally, data systems should be transparent: when a data system behaves unexpectedly or malfunctions, the users deserve proper explanation of what caused the observed incident. Unfortunately, most existing data systems offer limited usability and support for explanations: these systems are usable only by experts with sound technical skills, and even expert users are hindered by the lack of transparency into the systems\u27 inner workings and functions. The aim of my thesis is to bridge the usability gap between nonexpert users and complex data systems, aid all sort of users, including the expert ones, in data and system understanding, and provide explanations that help reason about unexpected outcomes involving data systems. Specifically, my thesis has the following three goals: (1) enhancing usability of data systems for nonexperts, (2) enable data understanding that can assist users in a variety of tasks such as achieving trust in data-driven machine learning, gaining data understanding, and data cleaning, and (3) explaining causes of unexpected outcomes involving data and data systems. For enhancing usability, we focus on example-driven user intent discovery. We develop systems based on example-driven interactions in two different settings: querying relational databases and personalized document summarization. Towards data understanding, we develop a new data-profiling primitive that can characterize tuples for which a machine-learned model is likely to produce untrustworthy predictions. We also develop an explanation framework to explain causes of such untrustworthy predictions. Additionally, this new data-profiling primitive enables interactive data cleaning. Finally, we develop two explanation frameworks, tailored to provide explanations in debugging data system components, including the data itself. The explanation frameworks focus on explaining the root cause of a concurrent application\u27s intermittent failure and exposing issues in the data that cause a data-driven system to malfunction

Machine Learning Models for Deciphering Regulatory Mechanisms and Morphological Variations in Cancer

The exponential growth of multi-omics biological datasets is resulting in an emerging paradigm shift in fundamental biological research. In recent years, imaging and transcriptomics datasets are increasingly incorporated into biological studies, pushing biology further into the domain of data-intensive-sciences. New approaches and tools from statistics, computer science, and data engineering are profoundly influencing biological research. Harnessing this ever-growing deluge of multi-omics biological data requires the development of novel and creative computational approaches. In parallel, fundamental research in data sciences and Artificial Intelligence (AI) has advanced tremendously, allowing the scientific community to generate a massive amount of knowledge from data. Advances in Deep Learning (DL), in particular, are transforming many branches of engineering, science, and technology. Several of these methodologies have already been adapted for harnessing biological datasets; however, there is still a need to further adapt and tailor these techniques to new and emerging technologies. In this dissertation, we present computational algorithms and tools that we have developed to study gene-regulation and cellular morphology in cancer. The models and platforms that we have developed are general and widely applicable to several problems relating to dysregulation of gene expression in diseases. Our pipelines and software packages are disseminated in public repositories for larger scientific community use. This dissertation is organized in three main projects. In the first project, we present Causal Inference Engine (CIE), an integrated platform for the identification and interpretation of active regulators of transcriptional response. The platform offers visualization tools and pathway enrichment analysis to map predicted regulators to Reactome pathways. We provide a parallelized R-package for fast and flexible directional enrichment analysis to run the inference on custom regulatory networks. Next, we designed and developed MODEX, a fully automated text-mining system to extract and annotate causal regulatory interaction between Transcription Factors (TFs) and genes from the biomedical literature. MODEX uses putative TF-gene interactions derived from high-throughput ChIP-Seq or other experiments and seeks to collect evidence and meta-data in the biomedical literature to validate and annotate the interactions. MODEX is a complementary platform to CIE that provides auxiliary information on CIE inferred interactions by mining the literature. In the second project, we present a Convolutional Neural Network (CNN) classifier to perform a pan-cancer analysis of tumor morphology, and predict mutations in key genes. The main challenges were to determine morphological features underlying a genetic status and assess whether these features were common in other cancer types. We trained an Inception-v3 based model to predict TP53 mutation in five cancer types with the highest rate of TP53 mutations. We also performed a cross-classification analysis to assess shared morphological features across multiple cancer types. Further, we applied a similar methodology to classify HER2 status in breast cancer and predict response to treatment in HER2 positive samples. For this study, our training slides were manually annotated by expert pathologists to highlight Regions of Interest (ROIs) associated with HER2+/- tumor microenvironment. Our results indicated that there are strong morphological features associated with each tumor type. Moreover, our predictions highly agree with manual annotations in the test set, indicating the feasibility of our approach in devising an image-based diagnostic tool for HER2 status and treatment response prediction. We have validated our model using samples from an independent cohort, which demonstrates the generalizability of our approach. Finally, in the third project, we present an approach to use spatial transcriptomics data to predict spatially-resolved active gene regulatory mechanisms in tissues. Using spatial transcriptomics, we identified tissue regions with differentially expressed genes and applied our CIE methodology to predict active TFs that can potentially regulate the marker genes in the region. This project bridged the gap between inference of active regulators using molecular data and morphological studies using images. The results demonstrate a significant local pattern in TF activity across the tissue, indicating differential spatial-regulation in tissues. The results suggest that the integrative analysis of spatial transcriptomics data with CIE can capture discriminant features and identify localized TF-target links in the tissue