8,318 research outputs found
Protein (Multi-)Location Prediction: Using Location Inter-Dependencies in a Probabilistic Framework
Knowing the location of a protein within the cell is important for
understanding its function, role in biological processes, and potential use as
a drug target. Much progress has been made in developing computational methods
that predict single locations for proteins, assuming that proteins localize to
a single location. However, it has been shown that proteins localize to
multiple locations. While a few recent systems have attempted to predict
multiple locations of proteins, they typically treat locations as independent
or capture inter-dependencies by treating each locations-combination present in
the training set as an individual location-class. We present a new method and a
preliminary system we have developed that directly incorporates
inter-dependencies among locations into the multiple-location-prediction
process, using a collection of Bayesian network classifiers. We evaluate our
system on a dataset of single- and multi-localized proteins. Our results,
obtained by incorporating inter-dependencies are significantly higher than
those obtained by classifiers that do not use inter-dependencies. The
performance of our system on multi-localized proteins is comparable to a top
performing system (YLoc+), without restricting predictions to be based only on
location-combinations present in the training set.Comment: Peer-reviewed and presented as part of the 13th Workshop on
Algorithms in Bioinformatics (WABI2013
Machine Learning in Wireless Sensor Networks: Algorithms, Strategies, and Applications
Wireless sensor networks monitor dynamic environments that change rapidly
over time. This dynamic behavior is either caused by external factors or
initiated by the system designers themselves. To adapt to such conditions,
sensor networks often adopt machine learning techniques to eliminate the need
for unnecessary redesign. Machine learning also inspires many practical
solutions that maximize resource utilization and prolong the lifespan of the
network. In this paper, we present an extensive literature review over the
period 2002-2013 of machine learning methods that were used to address common
issues in wireless sensor networks (WSNs). The advantages and disadvantages of
each proposed algorithm are evaluated against the corresponding problem. We
also provide a comparative guide to aid WSN designers in developing suitable
machine learning solutions for their specific application challenges.Comment: Accepted for publication in IEEE Communications Surveys and Tutorial
An Overview on Application of Machine Learning Techniques in Optical Networks
Today's telecommunication networks have become sources of enormous amounts of
widely heterogeneous data. This information can be retrieved from network
traffic traces, network alarms, signal quality indicators, users' behavioral
data, etc. Advanced mathematical tools are required to extract meaningful
information from these data and take decisions pertaining to the proper
functioning of the networks from the network-generated data. Among these
mathematical tools, Machine Learning (ML) is regarded as one of the most
promising methodological approaches to perform network-data analysis and enable
automated network self-configuration and fault management. The adoption of ML
techniques in the field of optical communication networks is motivated by the
unprecedented growth of network complexity faced by optical networks in the
last few years. Such complexity increase is due to the introduction of a huge
number of adjustable and interdependent system parameters (e.g., routing
configurations, modulation format, symbol rate, coding schemes, etc.) that are
enabled by the usage of coherent transmission/reception technologies, advanced
digital signal processing and compensation of nonlinear effects in optical
fiber propagation. In this paper we provide an overview of the application of
ML to optical communications and networking. We classify and survey relevant
literature dealing with the topic, and we also provide an introductory tutorial
on ML for researchers and practitioners interested in this field. Although a
good number of research papers have recently appeared, the application of ML to
optical networks is still in its infancy: to stimulate further work in this
area, we conclude the paper proposing new possible research directions
Inverse Modeling for MEG/EEG data
We provide an overview of the state-of-the-art for mathematical methods that
are used to reconstruct brain activity from neurophysiological data. After a
brief introduction on the mathematics of the forward problem, we discuss
standard and recently proposed regularization methods, as well as Monte Carlo
techniques for Bayesian inference. We classify the inverse methods based on the
underlying source model, and discuss advantages and disadvantages. Finally we
describe an application to the pre-surgical evaluation of epileptic patients.Comment: 15 pages, 1 figur
Thirty Years of Machine Learning: The Road to Pareto-Optimal Wireless Networks
Future wireless networks have a substantial potential in terms of supporting
a broad range of complex compelling applications both in military and civilian
fields, where the users are able to enjoy high-rate, low-latency, low-cost and
reliable information services. Achieving this ambitious goal requires new radio
techniques for adaptive learning and intelligent decision making because of the
complex heterogeneous nature of the network structures and wireless services.
Machine learning (ML) algorithms have great success in supporting big data
analytics, efficient parameter estimation and interactive decision making.
Hence, in this article, we review the thirty-year history of ML by elaborating
on supervised learning, unsupervised learning, reinforcement learning and deep
learning. Furthermore, we investigate their employment in the compelling
applications of wireless networks, including heterogeneous networks (HetNets),
cognitive radios (CR), Internet of things (IoT), machine to machine networks
(M2M), and so on. This article aims for assisting the readers in clarifying the
motivation and methodology of the various ML algorithms, so as to invoke them
for hitherto unexplored services as well as scenarios of future wireless
networks.Comment: 46 pages, 22 fig
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