Correlation between biomarkers of exposure, effect and potential harm in the urine of electronic cigarette users.

ObjectivesTo determine if urinary biomarkers of effect and potential harm are elevated in electronic cigarette users compared with non-smokers and if elevation correlates with increased concentrations of metals in urine.Study design and settingThis was a cross-sectional study of biomarkers of exposure, effect and potential harm in urine from non-smokers (n=20), electronic cigarette users (n=20) and cigarette smokers (n=13). Participant's screening and urine collection were performed at the Roswell Park Comprehensive Cancer Center, and biomarker analysis and metal analysis were performed at the University of California, Riverside.ResultsMetallothionein was significantly elevated in the electronic cigarette group (3761±3932 pg/mg) compared with the non-smokers (1129±1294 pg/mg, p=0.05). 8-OHdG (8-hydroxy-2'-deoxyguanosine) was significantly elevated in electronic cigarette users (442.8±300.7 ng/mg) versus non-smokers (221.6±157.8 ng/mg, p=0.01). 8-Isoprostane showed a significant increase in electronic cigarette users (750.8±433 pg/mg) versus non-smokers (411.2±287.4 pg/mg, p=0.03). Linear regression analysis in the electronic cigarette group showed a significant correlation between cotinine and total metal concentration; total metal concentration and metallothionein; cotinine and oxidative DNA damage; and total metal concentration and oxidative DNA damage. Zinc was significantly elevated in the electronic cigarette users (584.5±826.6 µg/g) compared with non-smokers (413.6±233.7 µg/g, p=0.03). Linear regression analysis showed a significant correlation between urinary zinc concentration and 8-OHdG in the electronic cigarette users.ConclusionsThis study is the first to investigate biomarkers of potential harm and effect in electronic cigarette users and to show a linkage to metal exposure. The biomarker levels in electronic cigarette users were similar to (and not lower than) cigarette smokers. In electronic cigarette users, there was a link to elevated total metal exposure and oxidative DNA damage. Specifically, our results demonstrate that zinc concentration was correlated to oxidative DNA damage

Faktor-faktor yang Berhubungan dengan Penggunaan Rokok Elektrik pada Perokok Pemuladi SMA Kota Bekasi

Based on the results of the preliminary survey that conducted by the researcher by spreading questionnaires to 581 High School students in Bekasi resulting 22.3% smoke electronic cigarette with details the active novice smokers who're using electronic cigarette in the amount of 8.3% while about 13.4% where the smokers who used to smoke tobacco cigarette are now moved on to electronic cigarette. The purpose of this research is to analyze the factors that associated with the USAge of electronic cigarette to novice smokers in Bekasi City's High School. The type of this research is descriptive analytic with quantitative approach method. The used research design is cross-sectional study, where the amount of the population in this research is 52 people who are novice electronic smokers in four Bekasi City's High School. The Total of Population technique is used to get the sample for this research where the entire population get the chance to be the sample for the research. Data analysis includes descriptive analysis with the presentation of the frequency distribution table and the analytic analysis uses Chi-Square test to see whether there or not there the relation between respondents' friends' support and family's support with the USAge of electronic cigarette in Bekasi City's High School. Statistical test results show that 67.3% respondents use electronic cigarrete. The variables related with the USAge of electronic cigarette to novice smokers in Bekasi City's High School is the availability of the electronic cigarette (p-value = 0.000), the affordability of the electronic cigarette (p-value = 0.000), and the respondents' friends' support (p-value = 0.016). While the respondents' knowledge about the electronic cigarette (p-vaalue = 0.416), the respondents' attitude to the USAge of the electronic cigarette (p-value = 0.538), the respondents' pocket money (p-value = 1.000) and the family's support (p-value = 0,238) is not related with the USAge of the electronic cigarette to novice smokers in Bekasi City's High School

Electronic Cigarette Using in Surabaya\u27s Personal Vaporizer Community

Electronic cigarette is devices capable of delivering nicotine in an aerosolized form. The number of electronic cigarette users is increasing. Data showed an Indonesia electronic cigarette user in 2010 to 2011 is 0,5%. This research was observasional decriptive study and used cross sectional design. This research was conducted to 31 Surabaya\u27s Personal Vaporizer members. The dependent variable in this study was electronic cigarette using, while independent variable were the knowledge, accessibility and family factor. Data were analyzed by prevalens ratio. The result showed that using of electronic cigarette mostly suffered by respondent age 26 to 35 years old was equal to 54,8%, male (96,8%) and educational level was senior high school to university (100%), occupation was employee (71%), had a smoking history (93,6%), and using electronic cigarette for smoking cessation (80,6%). The analyzed with prevalens ratio showed that right knowlegde about electronic cigarette was a protective factor to being using electronic cigarette (PR=0,89), accessibility ≤ Rp 100.000 was a risk to being using electronic cigarette, and family was a protective factor to being using electronic cigarette (PR=0,95). From all variable which were studied, only accessibility that a risk factor with electronic cigarette using. Therefore, education about electronic cigarette haved to do and controlling toward electronic cigarette user needed to do. Keywords : electronic cigarette, accessibility, community, knowledge, behavio

'Maybe they should regulate them quite strictly until they know the true dangers': A focus group study exploring UK adolescents’ views on e-cigarette regulation

Background and aims: Regulation of electronic cigarettes has moved to the top of the addiction policy agenda, as demonstrated by the recent focus across the UK on introducing age of sale restrictions. Yet, the views of those affected by such regulation remain largely unexplored. This paper presents the first detailed qualitative exploration of adolescents’ perceptions of existing, and opinions about potential, e-cigarette regulation. Methods: 16 focus groups, including a total of 83 teenagers between the ages of 14 and 17, were conducted in deprived, mixed and affluent urban areas in Scotland and England between November 2014 and February 2015. Transcripts were imported into Nivivo 10, thematically coded and analysed. Results: Participants critically considered existing evidence and competing interests in regulatory debates and demonstrated sophisticated understandings of the advantages and disadvantages of regulation. They overwhelmingly supported strong e-cigarette regulation and endorsed restrictions on sales to minors, marketing and e-cigarette use in public places. Concern about potential health harms of e-cigarette use and marketing increasing the acceptability of vaping and smoking led these adolescents to support regulation. Conclusions: In focus group discussions, a sample of UK adolescents exposed to particular communications about e-cigarettes supported strict regulation of e-cigarettes, including banning sales to minors and use in indoor public areas

Design Features in Multiple Generations of Electronic Cigarette Atomizers.

The design of electronic cigarette (EC) atomizing units has evolved since their introduction over 10 years ago. The purpose of this study was to evaluate atomizer design in ECs sold between 2011-2017. Atomizers from 34 brands representing three generations of ECs were dissected and photographed using a stereoscopic microscope. Five distinct atomizer design categories were identified in first generation products (cig-a-like/cartomizer) and three categories were found in the third generation. Atomizers in most cig-a-like ECs contained a filament, thick wire, wire joints, air-tube, wick, sheath, and fibers, while some later models lacked some of these components. Over time design changes included an increase in atomizer size; removal of solder joints between wires; removal of Polyfil fibers; and removal of the microprocessor from Vuse. In second and third generation ECs, the reservoirs and batteries were larger, and the atomizing units generally lacked a thick wire, fibers, and sheath. These data contribute to an understanding of atomizer design and show that there is no single design for ECs, which are continually evolving. The design of the atomizer is particularly important as it affects the performance of ECs and what transfers into the aerosol

Perbandingan Kualitas Spermatozoa Tikus Wistar (Rattus Norvegicus) Yang Diberi Paparan Asap Rokok Dengan Asap Rokok Elektronik

: Cigarette smoke contains three main components, carbon monoxide, nicotine, and tar which can cause disturbances in spermatogenesis. Smoke electronic cigarette contains three main components, nicotine, propylene gycol, and glyceryn which can cause disturbances in spermatogenesis. The purpose of this experiment is to compare the quality of spermatozoa Wistar rats by exposure to cigarette smoke and electronic cigarette smoke. This study is an experimental study using an approach of post test only control group design. Subject of the study were 9 rats Wistar male (Rattus norvegicus) were divided into 3 groups: group P0 is not given exposure to cigarette smoke and smoke the electronic cigarette, the group P1 is given exposure to smoke cigarettes 2 rods per day, group P2 is given exposure to smoke an electronic cigarette for two rods lit cigarette. Treatment was done for 50 days. The results showed the concentration of spermatozoa is difference between the treatment groups, but statistical analysis groups P0 and P1 showed a non-significant (p = 0.229), P0 and P2 group (p = 0.559), P1 and P2 group (p = 0.879). Motility P0 with P2 group (p = 0.008) and group P1 and P2 group (p = 0.026) showed significant differences which means there is a treatment effect on motility. While groups of P0 with P1 group (p = 0.209) did not show significant differences which means there is no treatment effect on motility. Morphology Control with treatment group 1 (p = 0.098) while the control group with treatment 2 (p = 0.004) it shows the morphology of the group P0 to P1 has no effect while the P0 to P2 there is an influence on the treatment

Electronic nicotine delivery systems: vaping away gum tissue

Objective: Conventional cigarettes have shown severe toxicity on immune cells and wound healing in the periodontium, but little is known about the comparative effects of vaping or electronic cigarettes. In a substantial shift away from conventional cigarettes, vaping and e-cigarette sales have increased nearly 600% since 2017. If current conventional cigarette users are to transition to a less detrimental alternative, the evidence must demonstrate if electronic nicotine delivery systems can be deemed safer than conventional options. Methods: By compiling data from the PubMed database, the most recent perspectives on new smoking methods and effects of usage on periodontal tissues were examined. The authors input various combinations of MeSH terms “electronic nicotine delivery system,” “periodontal,” “gingival” and “electronic cigarette.” Search results were filtered to only include studies within the last seven years, included all countries, and selective preference was given to primary research sources. Results: Electronic nicotine delivery systems have been shown to contribute to several pathophysiological effects including oxidative and carbonyl stress, inflammatory dysfunction, presence of apoptotic necrotic epithelial cells, and impaired fibroblastic activity. Evidence-based research has shown the use of electronic nicotine devices lead to changes in cellular activity which manifests as a strong risk factor for periodontal disease and fibrosis of the oral submucosa. The primary outcome measure of the health of the periodontium was indicated mainly by bleeding on probing, attachment loss and presence of inflammatory cells present. Conclusion: Electronic nicotine delivery systems are still being studied and studies are difficult to complete due to participants partaking in multiple forms of smoking. Although individuals transitioning from conventional to newer electronic nicotine delivery devices perceive making a healthy switch, scientific evidence indicates the risk of periodontal damage and disease are significant.https://scholarscompass.vcu.edu/denh_student/1006/thumbnail.jp

Prevalence, Reasons for Use, and Risk Perception of Electronic Cigarettes among Post-Acute Coronary Syndrome Smokers

Purpose—The use of electronic cigarettes (e-cigarettes) has risen dramatically in recent years. However, there is currently no published data on use of e-cigarettes among cardiac patients. The current study reports on the prevalence, reasons for use, and perceived risks of e-cigarettes among post-Acute Coronary Syndrome (ACS) patients. The relationship between e-cigarette use and post- ACS tobacco smoking cessation is also explored. Methods—Participants were drawn from a randomized trial of smoking cessation treatments following hospitalization for ACS. The current study focuses on 49 participants that completed e- cigarette questions at 24 weeks post-ACS. Results—51.0% of participants reported ever use of an e-cigarette and 26.5% reported using an e-cigarette at some time during the 24 weeks post-ACS. Ever use and post-ACS use were both significantly associated with lower rates of abstinence from tobacco cigarettes. Participants perceived e-cigarettes as less harmful to cardiac health than tobacco use and Chantix, and similarly harmful as nicotine replacement therapy. Participant perceived likelihood of experiencing a heart attack in the next year was 34.6% if they were to regularly use e-cigarettes only, significantly lower than perceived risk of recurrence if they were to regularly smoke only tobacco cigarettes (56.2%) and significantly higher than perceived risk of recurrence if they were to use no nicotine (15.2%). Conclusions—A significant minority of patients are using e-cigarettes post-ACS. Providers should be prepared to discuss potential discrepancies between patient beliefs about the safety of e- cigarettes and the current state of the science