90,104 research outputs found
Past, Present, and Future of Simultaneous Localization And Mapping: Towards the Robust-Perception Age
Simultaneous Localization and Mapping (SLAM)consists in the concurrent
construction of a model of the environment (the map), and the estimation of the
state of the robot moving within it. The SLAM community has made astonishing
progress over the last 30 years, enabling large-scale real-world applications,
and witnessing a steady transition of this technology to industry. We survey
the current state of SLAM. We start by presenting what is now the de-facto
standard formulation for SLAM. We then review related work, covering a broad
set of topics including robustness and scalability in long-term mapping, metric
and semantic representations for mapping, theoretical performance guarantees,
active SLAM and exploration, and other new frontiers. This paper simultaneously
serves as a position paper and tutorial to those who are users of SLAM. By
looking at the published research with a critical eye, we delineate open
challenges and new research issues, that still deserve careful scientific
investigation. The paper also contains the authors' take on two questions that
often animate discussions during robotics conferences: Do robots need SLAM? and
Is SLAM solved
Information-theoretic analysis of multivariate single - cell signaling responses using SLEMI
Mathematical methods of information theory constitute essential tools to
describe how stimuli are encoded in activities of signaling effectors.
Exploring the information-theoretic perspective, however, remains conceptually,
experimentally and computationally challenging. Specifically, existing
computational tools enable efficient analysis of relatively simple systems,
usually with one input and output only. Moreover, their robust and readily
applicable implementations are missing. Here, we propose a novel algorithm to
analyze signaling data within the framework of information theory. Our approach
enables robust as well as statistically and computationally efficient analysis
of signaling systems with high-dimensional outputs and a large number of input
values. Analysis of the NF-kB single - cell signaling responses to TNF-a
uniquely reveals that the NF-kB signaling dynamics improves discrimination of
high concentrations of TNF-a with a modest impact on discrimination of low
concentrations. Our readily applicable R-package, SLEMI - statistical learning
based estimation of mutual information, allows the approach to be used by
computational biologists with only elementary knowledge of information theory
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