A comparison of rotation- and blob-based system models for 3D SPECT with depth-dependent detector response

We compare two different implementations of a 3D SPECT system model for iterative reconstruction, both of which compensate for non-uniform photon attenuation and depth-dependent system response. One implementation performs fast rotation of images represented using a basis of rectangular voxels, whereas the other represents images using a basis of rotationally symmetric volume elements. In our simulations the blob-based approach was found to slightly outperform the rotation-based one in terms of the bias-variance trade-off in the reconstructed images. Their difference can be significant, however, in terms of computational load. The rotation-based method is faster for many typical SPECT reconstruction problems, but the blob-based one can be better-suited to cases where the reconstruction algorithm needs to process one volume element at a time.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/48977/2/pmb4_11_003.pd

A Scalable Framework for Monte Carlo Simulation Using FPGA-based Hardware Accelerators with Application to SPECT Imaging A SCALABLE FRAMEWORK FOR MONTE CARLO SIMULATION USING FPGA-BASED HARDWARE ACCELERATORS WITH APPLICATION TO SPECT IMAGING TITLE: A Scal

Abstract As the number of transistors that are integrated onto a silicon die continues to increase, the compute power is becoming a commodity. This has enabled a whole host of new applications that rely on high-throughput computations. Recently, the need for faster and cost-effective applications in form-factor constrained environments has driven an interest in on-chip acceleration of algorithms based on Monte Carlo simula- Processor. Futhermore, we have created a framework for further increasing parallelism by scaling our architecture across multiple compute devices and by extending our original design to a multi-FPGA system nearly linear increase in acceleration with logic resources was achieved. iv Acknowledgements One could hardly put into words the contributions made to this work by the many wonderful people who surround me on a daily basis. I count myself blessed to have family, friends and colleagues that support and encourage me and to recognize each individually would be impossible. Nonetheless, there are some people without whose explicit mention this thesis would be incomplete