A note on diastatic entropy and balanced metrics

We give un upper bound Ent(\Omega, g)<\lambda\ of the diastatic entropy Ent(\Omega, g) of a complex bounded domain (\Omega, g) in terms of the balanced condition (in Donaldson terminology) of the Kaehler metric \lambda g. When (\Omega, g) is a homogeneous bounded domain we show that the converse holds true, namely if Ent(\Omega, g)<1 then g is balanced. Moreover, we explcit compute Ent(\Omega, g) in terms of Piatetski-Shapiro constants.Comment: 7 page

Biotransformation of ent-beyerenes with mucor plumbeus

Indexación: Web of Science; Scielo.ABSTRACT The microbiological transformation of ent-beyer-15-en-18-ol 1 and ent-beyer-15-en-19-ol 2, using Mucorplumbeus, resulted in hydroxylated products. After nine days of incubation, 15β,16β-epoxide-ent-beyeran-7β,18-diol 3, ent-beyer-15-en-7p,19-diol 4 and 15β,16β-epoxide-ent-beyeran-7β,19-diol 5 were isolated. The metabolites were identified by spectroscopic methods. Key Words:http://ref.scielo.org/47kx2

Mechanism of action of VP1-001 in cryAB(R120G)-associated and age-related cataracts

PurposeWe previously identified an oxysterol, VP1-001 (also known as compound 29), that partially restores the transparency of lenses with cataracts. To understand the mechanism of VP1-001, we tested the ability of its enantiomer, ent-VP1-001, to bind and stabilize αB-crystallin (cryAB) in vitro and to produce a similar therapeutic effect in cryAB(R120G) mutant and aged wild-type mice with cataracts. VP1-001 and ent-VP1-001 have identical physicochemical properties. These experiments are designed to critically evaluate whether stereoselective binding to cryAB is required for activity.MethodsWe compared the binding of VP1-001 and ent-VP1-001 to cryAB using in silico docking, differential scanning fluorimetry (DSF), and microscale thermophoresis (MST). Compounds were delivered by six topical administrations to mouse eyes over 2 weeks, and the effects on cataracts and lens refractive measures in vivo were examined. Additionally, lens epithelial and fiber cell morphologies were assessed via transmission electron microscopy.ResultsDocking studies suggested greater binding of VP1-001 into a deep groove in the cryAB dimer compared with ent-VP1-001. Consistent with this prediction, DSF and MST experiments showed that VP1-001 bound cryAB, whereas ent-VP1-001 did not. Accordingly, topical treatment of lenses with ent-VP1-001 had no effect, whereas VP1-001 produced a statistically significant improvement in lens clarity and favorable changes in lens morphology.ConclusionsThe ability of VP1-001 to bind native cryAB dimers is important for its ability to reverse lens opacity in mouse models of cataracts

ARE LEFT HANDED SURGEONS LEFT OUT?

Being a left-handed surgeon, more specifically a left-handed ENT surgeon, presents a unique pattern of difficulties.This article is an overview of left-handedness and a personal account of the specific difficulties a left-handed ENT surgeon faces. 

Future Facilities Summary

For the session on future facilities at DIS09 discussions were organized on DIS related measurements that can be expected in the near and medium - or perhaps far - future, including plans from JLab, CERN and FNAL fixed target experiments, possible measurements and detector upgrades at RHIC, as well as the plans for possible future electron proton/ion colliders such as the EIC and the LHeC project.Comment: Summary of the parallel sessions on future facilities and the plenary discussion session on possible future electron proton/ion colliders such as the EIC and the LHeC project at the Deep Inelastic Scattering workshop in Madrid, April 200