9,388 research outputs found
Visualizing dimensionality reduction of systems biology data
One of the challenges in analyzing high-dimensional expression data is the
detection of important biological signals. A common approach is to apply a
dimension reduction method, such as principal component analysis. Typically,
after application of such a method the data is projected and visualized in the
new coordinate system, using scatter plots or profile plots. These methods
provide good results if the data have certain properties which become visible
in the new coordinate system and which were hard to detect in the original
coordinate system. Often however, the application of only one method does not
suffice to capture all important signals. Therefore several methods addressing
different aspects of the data need to be applied. We have developed a framework
for linear and non-linear dimension reduction methods within our visual
analytics pipeline SpRay. This includes measures that assist the interpretation
of the factorization result. Different visualizations of these measures can be
combined with functional annotations that support the interpretation of the
results. We show an application to high-resolution time series microarray data
in the antibiotic-producing organism Streptomyces coelicolor as well as to
microarray data measuring expression of cells with normal karyotype and cells
with trisomies of human chromosomes 13 and 21
Coarse-graining the Dynamics of a Driven Interface in the Presence of Mobile Impurities: Effective Description via Diffusion Maps
Developing effective descriptions of the microscopic dynamics of many
physical phenomena can both dramatically enhance their computational
exploration and lead to a more fundamental understanding of the underlying
physics. Previously, an effective description of a driven interface in the
presence of mobile impurities, based on an Ising variant model and a single
empirical coarse variable, was partially successful; yet it underlined the
necessity of selecting additional coarse variables in certain parameter
regimes. In this paper we use a data mining approach to help identify the
coarse variables required. We discuss the implementation of this diffusion map
approach, the selection of a similarity measure between system snapshots
required in the approach, and the correspondence between empirically selected
and automatically detected coarse variables. We conclude by illustrating the
use of the diffusion map variables in assisting the atomistic simulations, and
we discuss the translation of information between fine and coarse descriptions
using lifting and restriction operators.Comment: 28 pages, 10 figure
On the interpretation and identification of dynamic Takagi-Sugenofuzzy models
Dynamic Takagi-Sugeno fuzzy models are not always easy to interpret, in particular when they are identified from experimental data. It is shown that there exists a close relationship between dynamic Takagi-Sugeno fuzzy models and dynamic linearization when using affine local model structures, which suggests that a solution to the multiobjective identification problem exists. However, it is also shown that the affine local model structure is a highly sensitive parametrization when applied in transient operating regimes. Due to the multiobjective nature of the identification problem studied here, special considerations must be made during model structure selection, experiment design, and identification in order to meet both objectives. Some guidelines for experiment design are suggested and some robust nonlinear identification algorithms are studied. These include constrained and regularized identification and locally weighted identification. Their usefulness in the present context is illustrated by examples
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