Enrichment of innate lymphoid cell populations in gingival tissue

Innate lymphoid cells (ILCs) are a population of lymphocytes that act as the first line of immunologic defense at mucosal surfaces. The ILC family in the skin, lungs, and gastrointestinal tissues has been investigated, and there are reports of individual subsets of ILCs in the oral tissues. We sought to investigate the whole ILC population (group 1, 2, and 3 subsets) in the murine gingivae and the lymph nodes draining the oral cavity. We show that ILCs made up a greater proportion of the whole CD45+ lymphocyte population in the murine gingivae (0.356% ± 0.039%) as compared with the proportion of ILCs in the draining lymph nodes (0.158% ± 0.005%). Cytokine profiling of the ILC populations demonstrated different proportions of ILC subsets in the murine gingivae versus the regional lymph nodes. The majority of ILCs in the draining lymph nodes expressed IL-5, whereas there were equal proportions of IFN-γ- and IL-5 expressing ILCs in the oral mucosa. The percentage of IL-17+ ILCs was comparable between the murine gingivae and the oral draining lymph nodes. These data suggest an enrichment of ILCs in the murine gingivae, and these ILCs reflect a cytokine profile discrepant to that of the local draining lymph nodes. These studies indicate diversity and enrichment of ILCs at the oral mucosal surface. The function of ILCs in the oral cavity remains to be determined; here, we provide a premise of ILC populations that merits future consideration in investigations of mouse models and human tissues

A simple model for the anomalous intrinsic viscosity of dendrimers

The intrinsic viscosity of dendrimers in solution shows several anomalous behaviors that have hitherto not been explained within the existing theoretical frameworks of either Zimm or Rouse. Here we propose a simple two-zone model based on the radial segmental density profile of the dendrimers and combine a non-draining core with a free-draining outer region description, to arrive at a simple formula that captures most of the main features in the intrinsic viscosity data obtained in experiments

Dynamic Looping of a Free-Draining Polymer

We revisit the celebrated Wilemski-Fixman (WF) treatment for the looping time of a free-draining polymer. The WF theory introduces a sink term into the Fokker-Planck equation for the $3(N+1)$-dimensional Ornstein-Uhlenbeck process of the polymer dynamics, which accounts for the appropriate boundary condition due to the formation of a loop. The assumption for WF theory is considerably relaxed. A perturbation method approach is developed that justifies and generalizes the previous results using either a Delta sink or a Heaviside sink. For both types of sinks, we show that under the condition of a small dimensionless $\epsilon$, the ratio of capture radius to the Kuhn length, we are able to systematically produce all known analytical and asymptotic results obtained by other methods. This includes most notably the transition regime between the $N^2$ scaling of Doi, and $N\sqrt{N}/\epsilon$ scaling of Szabo, Schulten, and Schulten. The mathematical issue at play is the non-uniform convergence of $\epsilon\to 0$ and $N\to\infty$, the latter being an inherent part of the theory of a Gaussian polymer. Our analysis yields a novel term in the analytical expression for the looping time with small $\epsilon$, which is previously unknown. Monte Carlo numerical simulations corroborate the analytical findings. The systematic method developed here can be applied to other systems modeled by multi-dimensional Smoluchowski equations.Comment: 20 pages, 4 figure

Improving Macrocell - Small Cell Coexistence through Adaptive Interference Draining

The deployment of underlay small base stations (SBSs) is expected to significantly boost the spectrum efficiency and the coverage of next-generation cellular networks. However, the coexistence of SBSs underlaid to an existing macro-cellular network faces important challenges, notably in terms of spectrum sharing and interference management. In this paper, we propose a novel game-theoretic model that enables the SBSs to optimize their transmission rates by making decisions on the resource occupation jointly in the frequency and spatial domains. This procedure, known as interference draining, is performed among cooperative SBSs and allows to drastically reduce the interference experienced by both macro- and small cell users. At the macrocell side, we consider a modified water-filling policy for the power allocation that allows each macrocell user (MUE) to focus the transmissions on the degrees of freedom over which the MUE experiences the best channel and interference conditions. This approach not only represents an effective way to decrease the received interference at the MUEs but also grants the SBSs tier additional transmission opportunities and allows for a more agile interference management. Simulation results show that the proposed approach yields significant gains at both macrocell and small cell tiers, in terms of average achievable rate per user, reaching up to 37%, relative to the non-cooperative case, for a network with 150 MUEs and 200 SBSs

The inferior caval vein draining into the left atrial cavity : a rare case

The inferior vena cava (IVC) draining into the left atrium (LA) is exceedingly rare in the setting of the usual atrial arrangement (situs solitus). This article describes a patient with this unique anomaly, and its repair.peer-reviewe

Draining the Water Hole: Mitigating Social Engineering Attacks with CyberTWEAK

Cyber adversaries have increasingly leveraged social engineering attacks to breach large organizations and threaten the well-being of today's online users. One clever technique, the "watering hole" attack, compromises a legitimate website to execute drive-by download attacks by redirecting users to another malicious domain. We introduce a game-theoretic model that captures the salient aspects for an organization protecting itself from a watering hole attack by altering the environment information in web traffic so as to deceive the attackers. Our main contributions are (1) a novel Social Engineering Deception (SED) game model that features a continuous action set for the attacker, (2) an in-depth analysis of the SED model to identify computationally feasible real-world cases, and (3) the CyberTWEAK algorithm which solves for the optimal protection policy. To illustrate the potential use of our framework, we built a browser extension based on our algorithms which is now publicly available online. The CyberTWEAK extension will be vital to the continued development and deployment of countermeasures for social engineering.Comment: IAAI-20, AICS-2020 Worksho

Charter School Funding: Inequity’s Next Frontier

Of all the controversies swirling around the nation’s charter schools, none is more hotly contested than the debate over funding. Charter opponents charge that] these autonomous public schools are draining scarce resources from public school districts. Proponents, by contrast, complain that charter schools do not get their fair share of public education dollars