Detecting Mental Distresses Using Social Behavior Analysis in the Context of COVID-19: A Survey

Online social media provides a channel for monitoring people\u27s social behaviors from which to infer and detect their mental distresses. During the COVID-19 pandemic, online social networks were increasingly used to express opinions, views, and moods due to the restrictions on physical activities and in-person meetings, leading to a significant amount of diverse user-generated social media content. This offers a unique opportunity to examine how COVID-19 changed global behaviors regarding its ramifications on mental well-being. In this article, we surveyed the literature on social media analysis for the detection of mental distress, with a special emphasis on the studies published since the COVID-19 outbreak. We analyze relevant research and its characteristics and propose new approaches to organizing the large amount of studies arising from this emerging research area, thus drawing new views, insights, and knowledge for interested communities. Specifically, we first classify the studies in terms of feature extraction types, language usage patterns, aesthetic preferences, and online behaviors. We then explored various methods (including machine learning and deep learning techniques) for detecting mental health problems. Building upon the in-depth review, we present our findings and discuss future research directions and niche areas in detecting mental health problems using social media data. We also elaborate on the challenges of this fast-growing research area, such as technical issues in deploying such systems at scale as well as privacy and ethical concerns

Modern Views of Machine Learning for Precision Psychiatry

In light of the NIMH's Research Domain Criteria (RDoC), the advent of functional neuroimaging, novel technologies and methods provide new opportunities to develop precise and personalized prognosis and diagnosis of mental disorders. Machine learning (ML) and artificial intelligence (AI) technologies are playing an increasingly critical role in the new era of precision psychiatry. Combining ML/AI with neuromodulation technologies can potentially provide explainable solutions in clinical practice and effective therapeutic treatment. Advanced wearable and mobile technologies also call for the new role of ML/AI for digital phenotyping in mobile mental health. In this review, we provide a comprehensive review of the ML methodologies and applications by combining neuroimaging, neuromodulation, and advanced mobile technologies in psychiatry practice. Additionally, we review the role of ML in molecular phenotyping and cross-species biomarker identification in precision psychiatry. We further discuss explainable AI (XAI) and causality testing in a closed-human-in-the-loop manner, and highlight the ML potential in multimedia information extraction and multimodal data fusion. Finally, we discuss conceptual and practical challenges in precision psychiatry and highlight ML opportunities in future research

Identifying Depressive Symptoms from Tweets: Figurative Language Enabled Multitask Learning Framework

Existing studies on using social media for deriving mental health status of users focus on the depression detection task. However, for case management and referral to psychiatrists, healthcare workers require practical and scalable depressive disorder screening and triage system. This study aims to design and evaluate a decision support system (DSS) to reliably determine the depressive triage level by capturing fine-grained depressive symptoms expressed in user tweets through the emulation of Patient Health Questionnaire-9 (PHQ-9) that is routinely used in clinical practice. The reliable detection of depressive symptoms from tweets is challenging because the 280-character limit on tweets incentivizes the use of creative artifacts in the utterances and figurative usage contributes to effective expression. We propose a novel BERT based robust multi-task learning framework to accurately identify the depressive symptoms using the auxiliary task of figurative usage detection. Specifically, our proposed novel task sharing mechanism, co-task aware attention, enables automatic selection of optimal information across the BERT layers and tasks by soft-sharing of parameters. Our results show that modeling figurative usage can demonstrably improve the model\u27s robustness and reliability for distinguishing the depression symptoms

Moment-to-moment mood change modelling in mobile mental health network

Human interests and behaviour change over time and often affected by multiple factors. In particular, human emotions, mood and its constituent processes change and interact over time. Therefore, modelling human behaviour should take into account the changes over time for customization and adaptation of systems to the users’ specific needs. Understanding and assessing the temporal dynamics of mood are critical for modelling human behaviour for both individuals and group of people who share similar habits, life style and personal circumstances. Thus, in order to construct a personalized recommendation for a given user, it is first necessary to have some knowledge about previous user interests and behaviours. However, the challenge of obtaining large-scale data on human emotions has left the most fundamental questions on emotions less explored: How do emotions vary across individuals, evolve over time, and are connected to social ties? We address these questions using a large-scale dataset of users that contains both their users’ interactions with momentary emotions and topical labels. Using this dataset, we identify patterns of human emotions on different levels, starting from the network level, group-level (cluster) and moving towards the user level. At the user-level, we identify how human emotions are distributed and vary over time. In particular, we model changes in mood using multi-level multimodal features including users’ sentimental status, engagement and linguistic queries. We also utilise language models to model and understand patterns of mood change. We model the changes of users’ mental states based on replies and responses to posts over time and predict future states. We find that the future mental states can be predicted with reasonable accuracy given users’ historical posts, current participation features. Our findings form a step forward towards better understand the interplay between user behaviour and mood change exhibited while interacting on mental health network and providing some interpretable summaries that can be used in the future by health experts and individuals and work on possible medical interventions together with clinical experts

EEG based Major Depressive disorder and Bipolar disorder detection using Neural Networks: A review

Mental disorders represent critical public health challenges as they are leading contributors to the global burden of disease and intensely influence social and financial welfare of individuals. The present comprehensive review concentrate on the two mental disorders: Major depressive Disorder (MDD) and Bipolar Disorder (BD) with noteworthy publications during the last ten years. There is a big need nowadays for phenotypic characterization of psychiatric disorders with biomarkers. Electroencephalography (EEG) signals could offer a rich signature for MDD and BD and then they could improve understanding of pathophysiological mechanisms underling these mental disorders. In this review, we focus on the literature works adopting neural networks fed by EEG signals. Among those studies using EEG and neural networks, we have discussed a variety of EEG based protocols, biomarkers and public datasets for depression and bipolar disorder detection. We conclude with a discussion and valuable recommendations that will help to improve the reliability of developed models and for more accurate and more deterministic computational intelligence based systems in psychiatry. This review will prove to be a structured and valuable initial point for the researchers working on depression and bipolar disorders recognition by using EEG signals.Comment: 29 pages,2 figures and 18 Table

Emotion-aware voice interfaces based on speech signal processing

Voice interfaces (VIs) will become increasingly widespread in current daily lives as AI techniques progress. VIs can be incorporated into smart devices like smartphones, as well as integrated into autos, home automation systems, computer operating systems, and home appliances, among other things. Current speech interfaces, however, are unaware of users’ emotional states and hence cannot support real communication. To overcome these limitations, it is necessary to implement emotional awareness in future VIs. This thesis focuses on how speech signal processing (SSP) and speech emotion recognition (SER) can enable VIs to gain emotional awareness. Following an explanation of what emotion is and how neural networks are implemented, this thesis presents the results of several user studies and surveys. Emotions are complicated, and they are typically characterized using category and dimensional models. They can be expressed verbally or nonverbally. Although existing voice interfaces are unaware of users’ emotional states and cannot support natural conversations, it is possible to perceive users’ emotions by speech based on SSP in future VIs. One section of this thesis, based on SSP, investigates mental restorative effects on humans and their measures from speech signals. SSP is less intrusive and more accessible than traditional measures such as attention scales or response tests, and it can provide a reliable assessment for attention and mental restoration. SSP can be implemented into future VIs and utilized in future HCI user research. The thesis then moves on to present a novel attention neural network based on sparse correlation features. The detection accuracy of emotions in the continuous speech was demonstrated in a user study utilizing recordings from a real classroom. In this section, a promising result will be shown. In SER research, it is unknown if existing emotion detection methods detect acted emotions or the genuine emotion of the speaker. Another section of this thesis is concerned with humans’ ability to act on their emotions. In a user study, participants were instructed to imitate five fundamental emotions. The results revealed that they struggled with this task; nevertheless, certain emotions were easier to replicate than others. A further study concern is how VIs should respond to users’ emotions if SER techniques are implemented in VIs and can recognize users’ emotions. The thesis includes research on ways for dealing with the emotions of users. In a user study, users were instructed to make sad, angry, and terrified VI avatars happy and were asked if they would like to be treated the same way if the situation were reversed. According to the results, the majority of participants tended to respond to these unpleasant emotions with neutral emotion, but there is a difference among genders in emotion selection. For a human-centered design approach, it is important to understand what the users’ preferences for future VIs are. In three distinct cultures, a questionnaire-based survey on users’ attitudes and preferences for emotion-aware VIs was conducted. It was discovered that there are almost no gender differences. Cluster analysis found that there are three fundamental user types that exist in all cultures: Enthusiasts, Pragmatists, and Sceptics. As a result, future VI development should consider diverse sorts of consumers. In conclusion, future VIs systems should be designed for various sorts of users as well as be able to detect the users’ disguised or actual emotions using SER and SSP technologies. Furthermore, many other applications, such as restorative effects assessments, can be included in the VIs system

Automatic vocalisation-based detection of fragile X syndrome and Rett syndrome

Fragile X syndrome (FXS) and Rett syndrome (RTT) are developmental disorders currently not diagnosed before toddlerhood. Even though speech-language deficits are among the key symptoms of both conditions, little is known about infant vocalisation acoustics for an automatic earlier identification of affected individuals. To bridge this gap, we applied intelligent audio analysis methodology to a compact dataset of 4454 home-recorded vocalisations of 3 individuals with FXS and 3 individuals with RTT aged 6 to 11 months, as well as 6 age- and gender-matched typically developing controls (TD). On the basis of a standardised set of 88 acoustic features, we trained linear kernel support vector machines to evaluate the feasibility of automatic classification of (a) FXS vs TD, (b) RTT vs TD, (c) atypical development (FXS+RTT) vs TD, and (d) FXS vs RTT vs TD. In paradigms (a)–(c), all infants were correctly classified; in paradigm (d), 9 of 12 were so. Spectral/cepstral and energy-related features were most relevant for classification across all paradigms. Despite the small sample size, this study reveals new insights into early vocalisation characteristics in FXS and RTT, and provides technical underpinnings for a future earlier identification of affected individuals, enabling earlier intervention and family counselling

Deep learning with knowledge graphs for fine-grained emotion classification in text

This PhD thesis investigates two key challenges in the area of fine-grained emotion detection in textual data. More specifically, this work focuses on (i) the accurate classification of emotion in tweets and (ii) improving the learning of representations from knowledge graphs using graph convolutional neural networks.The first part of this work outlines the task of emotion keyword detection in tweets and introduces a new resource called the EEK dataset. Tweets have previously been categorised as short sequences or sentence-level sentiment analysis, and it could be argued that this should no longer be the case, especially since Twitter increased its allowed character limit. Recurrent Neural Networks have become a well-established method to classify tweets over recent years, but have struggled with accurately classifying longer sequences due to the vanishing and exploding gradient descent problem. A common technique to overcome this problem has been to prune tweets to a shorter sequence length. However, this also meant that often potentially important emotion carrying information, which is often found towards the end of a tweet, was lost (e.g., emojis and hashtags). As such, tweets mostly face also problems with classifying long sequences, similar to other natural language processing tasks. To overcome these challenges, a multi-scale hierarchical recurrent neural network is proposed and benchmarked against other existing methods. The proposed learning model outperforms existing methods on the same task by up to 10.52%. Another key component for the accurate classification of tweets has been the use of language models, where more recent techniques such as BERT and ELMO have achieved great success in a range of different tasks. However, in Sentiment Analysis, a key challenge has always been to use language models that do not only take advantage of the context a word is used in but also the sentiment it carries. Therefore the second part of this work looks at improving representation learning for emotion classification by introducing both linguistic and emotion knowledge to language models. A new linguistically inspired knowledge graph called RELATE is introduced. Then a new language model is trained on a Graph Convolutional Neural Network and compared against several other existing language models, where it is found that the proposed embedding representations achieve competitive results to other LMs, whilst requiring less pre-training time and data. Finally, it is investigated how the proposed methods can be applied to document-level classification tasks. More specifically, this work focuses on the accurate classification of suicide notes and analyses whether sentiment and linguistic features are important for accurate classification

A step towards Advancing Digital Phenotyping In Mental Healthcare

Smartphones and wrist-wearable devices have infiltrated our lives in recent years. According to published statistics, nearly 84% of the world’s population owns a smartphone, and almost 10% own a wearable device today (2022). These devices continuously generate various data sources from multiple sensors and apps, creating our digital phenotypes. This opens new research opportunities, particularly in mental health care, which has previously relied almost exclusively on self-reports of mental health symptoms. Unobtrusive monitoring using patients’ devices may result in clinically valuable markers that can improve diagnostic processes, tailor treatment choices, provide continuous insights into their condition for actionable outcomes, such as early signs of relapse, and develop new intervention models. However, these data sources must be translated into meaningful, actionable features related to mental health to achieve their full potential. In the mental health field, there is a great need and much to be gained from defining a way to continuously assess the evolution of patients’ mental states, ideally in their everyday environment, to support the monitoring and treatments by health care providers. A smartphone-based approach may be valuable in gathering long-term objective data, aside from the usually used self-ratings, to predict clinical state changes and investigate causal inferences about state changes in patients (e.g., those with affective disorders). Being objective does not imply that passive data collection is also perfect. It has several challenges: some sensors generate vast volumes of data, and others cause significant battery drain. Furthermore, the analysis of raw passive data is complicated, and collecting certain types of data may interfere with the phenotype of interest. Nonetheless, machine learning is predisposed to address these matters and advance psychiatry’s era of personalised medicine. This work aimed to advance the research efforts on mobile and wearable sensors for mental health monitoring. We applied supervised and unsupervised machine learning methods to model and understand mental disease evolution based on the digital phenotype of patients and clinician assessments at the follow-up visits, which provide ground truths. We needed to cope with regularly and irregularly sampled, high-dimensional, and heterogeneous time series data susceptible to distortion and missingness. Hence, the developed methods must be robust to these limitations and handle missing data properly. Throughout the various projects presented here, we used probabilistic latent variable models for data imputation and feature extraction, namely, mixture models (MM) and hidden Markov models (HMM). These unsupervised models can learn even in the presence of missing data by marginalising the missing values in the function of the present observations. Once the generative models are trained on the data set with missing values, they can be used to generate samples for imputation. First, the most probable component/state has to be found for each sample. Then, sampling from the most probable distribution yields valid and robust parameter estimates and explicit imputed values for variables that can be analysed as outcomes or predictors. The imputation process can be repeated several times, creating multiple datasets, thereby accounting for the uncertainty in the imputed values and implicitly augmenting the data. Moreover, they are robust to moderate deviations of the observed data from the assumed underlying distribution and provide accurate estimates even when missingness is high. Depending on the properties of the data at hand, we employed feature extraction methods combined with classical machine learning algorithms or deep learning-based techniques for temporal modelling to predict various mental health outcomes - emotional state, World Health Organisation Disability Assessment Schedule (WHODAS 2.0) functionality scores and Generalised Anxiety Disorder-7 (GAD-7) scores, of psychiatric outpatients. We mainly focused on one-size-fits-all models, as the labelled sample size per patient was limited; however, in the mood prediction case, it was possible to apply personalised models. Integrating machines and algorithms into the clinical workflow require interpretability to increase acceptance. Therefore, we also analysed feature importance by computing Shapley additive explanations (SHAP) values. SHAP values provide an overview of essential features in the machine learning models by designating the weight of predictability of each feature positively or negatively to the target variable. The provided solutions, as such, are proof of concept, which require further clinical validation to be deployable in the clinical workflow. Still, the results are promising and lay some foundations for future research and collaboration among clinicians, patients, and computer scientists. They set the paths to advance future research prospects in technology-based mental healthcare.En los últimos años, los smartphones y los dispositivos y pulseras inteligentes, comúnmente conocidos como wearables, se han infiltrado en nuestras vidas. Según las estadísticas publicadas a día de hoy (2022), cerca del 84% de la población tiene un smartphone y aproximadamente un 10% también posee un wearable. Estos dispositivos generan datos de forma continua en base a distintos sensores y aplicaciones, creando así nuestro fenotipo digital. Estos datos abren nuevas vías de investigación, particularmente en el área de salud mental, dónde las fuentes de datos han sido casi exclusivamente autoevaluaciones de síntomas de salud mental. Monitorizar de forma no intrusiva a los pacientes mediante sus dispositivos puede dar lugar a marcadores valiosos en aplicación clínica. Esto permite mejorar los procesos de diagnóstico, adaptar tratamientos, e incluso proporcionar información continua sobre el estado de los pacientes, como signos tempranos de recaída, y hasta desarrollar nuevos modelos de intervención. Aun así, estos datos en crudo han de ser traducidos a datos interpretables relacionados con la salud mental para conseguir un máximo rendimiento de los mismos. En salud mental existe una gran necesidad, y además hay mucho que ganar, de definir cómo evaluar de forma continuada la evolución del estado mental de los pacientes en su entorno cotidiano para ayudar en el tratamiento y seguimiento de los mismos por parte de los profesionales sanitarios. En este ámbito, un enfoque basado en datos recopilados desde sus smartphones puede ser valioso para recoger datos objetivos a largo plazo al mismo tiempo que se acompaña de las autoevaluaciones utilizadas habitualmente. La combinación de ambos tipos de datos puede ayudar a predecir los cambios en el estado clínico de estos pacientes e investigar las relaciones causales sobre estos cambios (por ejemplo, en aquellos que padecen trastornos afectivos). Aunque la recogida de datos de forma pasiva tiene la ventaja de ser objetiva, también implica varios retos. Por un lado, ciertos sensores generan grandes volúmenes de datos, provocando un importante consumo de batería. Además, el análisis de los datos pasivos en crudo es complicado, y la recogida de ciertos tipos de datos puede interferir con el fenotipo que se quiera analizar. No obstante, el machine learning o aprendizaje automático, está predispuesto a resolver estas cuestiones y aportar avances en la medicina personalizada aplicada a psiquiatría. Esta tesis tiene como objetivo avanzar en la investigación de los datos recogidos por sensores de smartphones y wearables para la monitorización en salud mental. Para ello, aplicamos métodos de aprendizaje automático supervisado y no supervisado para modelar y comprender la evolución de las enfermedades mentales basándonos en el fenotipo digital de los pacientes. Estos resultados se comparan con las evaluaciones de los médicos en las visitas de seguimiento, que proporcionan las etiquetas reales. Para aplicar estos métodos hemos lidiado con datos provenientes de series temporales con alta dimensionalidad, muestreados de forma regular e irregular, heterogéneos y, además, susceptibles a presentar patrones de datos perdidos y/o distorsionados. Por lo tanto, los métodos desarrollados deben ser resistentes a estas limitaciones y manejar adecuadamente los datos perdidos. A lo largo de los distintos proyectos presentados en este trabajo, hemos utilizado modelos probabilísticos de variables latentes para la imputación de datos y la extracción de características, como por ejemplo, Mixture Models (MM) y hidden Markov Models (HMM). Estos modelos no supervisados pueden aprender incluso en presencia de datos perdidos, marginalizando estos valores en función de las datos que sí han sido observados. Una vez entrenados los modelos generativos en el conjunto de datos con valores perdidos, pueden utilizarse para imputar dichos valores generando muestras. En primer lugar, hay que encontrar el componente/estado más probable para cada muestra. Luego, se muestrea de la distirbución más probable resultando en estimaciones de parámetros robustos y válidos. Además, genera imputaciones explícitas que pueden ser tratadas como resultados. Este proceso de imputación puede repetirse varias veces, creando múltiples conjuntos de datos, con lo que se tiene en cuenta la incertidumbre de los valores imputados y aumentándose así, implícitamente, los datos. Además, estas imputaciones son resistentes a desviaciones que puedan existir en los datos observados con respecto a la distribución subyacente asumida y proporcionan estimaciones precisas incluso cuando la falta de datos es elevada. Dependiendo de las propiedades de los datos en cuestión, hemos usado métodos de extracción de características combinados con algoritmos clásicos de aprendizaje automático o técnicas basadas en deep learning o aprendizaje profundo para el modelado temporal. La finalidad de ambas opciones es ser capaces de predecir varios resultados de salud mental/estado emocional, como la puntuación sobre el World Health Organisation Disability Assessment Schedule (WHODAS 2.0), o las puntuaciones del generalised anxiety disorder-7 (GAD-7) de pacientes psiquiátricos ambulatorios. Nos centramos principalmente en modelos generalizados, es decir, no personalizados para cada paciente sino explicativos para la mayoría, ya que el tamaño de muestras etiquetada por paciente es limitado; sin embargo, en el caso de la predicción del estado de ánimo, puidmos aplicar modelos personalizados. Para que la integración de las máquinas y algoritmos dentro del flujo de trabajo clínico sea aceptada, se requiere que los resultados sean interpretables. Por lo tanto, en este trabajo también analizamos la importancia de las características sacadas por cada algoritmo en base a los valores de las explicaciones aditivas de Shapley (SHAP). Estos valores proporcionan una visión general de las características esenciales en los modelos de aprendizaje automático designando el peso, positivo o negativo, de cada característica en su predictibilidad sobre la variable objetivo. Las soluciones aportadas en esta tesis, como tales, son pruebas de concepto, que requieren una mayor validación clínica para poder ser desplegadas en el flujo de trabajo clínico. Aun así, los resultados son prometedores y sientan base para futuras investigaciones y colaboraciones entre clínicos, pacientes y científicos de datos. Éstas establecen las guías para avanzar en las perspectivas de investigación futuras en la atención sanitaria mental basada en la tecnología.Programa de Doctorado en Multimedia y Comunicaciones por la Universidad Carlos III de Madrid y la Universidad Rey Juan CarlosPresidente: David Ramírez García.- Secretario: Alfredo Nazábal Rentería.- Vocal: María Luisa Barrigón Estéve