17,471 research outputs found
Efficient fetal-maternal ECG signal separation from two channel maternal abdominal ECG via diffusion-based channel selection
There is a need for affordable, widely deployable maternal-fetal ECG monitors
to improve maternal and fetal health during pregnancy and delivery. Based on
the diffusion-based channel selection, here we present the mathematical
formalism and clinical validation of an algorithm capable of accurate
separation of maternal and fetal ECG from a two channel signal acquired over
maternal abdomen
Aerospace Medicine and Biology: A continuing bibliography with indexes, supplement 127, April 1974
This special bibliography lists 279 reports, articles, and other documents introduced into the NASA scientific and technical information system in March 1974
Estimating Carotid Pulse and Breathing Rate from Near-infrared Video of the Neck
Objective: Non-contact physiological measurement is a growing research area
that allows capturing vital signs such as heart rate (HR) and breathing rate
(BR) comfortably and unobtrusively with remote devices. However, most of the
approaches work only in bright environments in which subtle
photoplethysmographic and ballistocardiographic signals can be easily analyzed
and/or require expensive and custom hardware to perform the measurements.
Approach: This work introduces a low-cost method to measure subtle motions
associated with the carotid pulse and breathing movement from the neck using
near-infrared (NIR) video imaging. A skin reflection model of the neck was
established to provide a theoretical foundation for the method. In particular,
the method relies on template matching for neck detection, Principal Component
Analysis for feature extraction, and Hidden Markov Models for data smoothing.
Main Results: We compared the estimated HR and BR measures with ones provided
by an FDA-cleared device in a 12-participant laboratory study: the estimates
achieved a mean absolute error of 0.36 beats per minute and 0.24 breaths per
minute under both bright and dark lighting.
Significance: This work advances the possibilities of non-contact
physiological measurement in real-life conditions in which environmental
illumination is limited and in which the face of the person is not readily
available or needs to be protected. Due to the increasing availability of NIR
imaging devices, the described methods are readily scalable.Comment: 21 pages, 15 figure
Aerospace medicine and biology: A continuing bibliography with indexes, supplement 183
This bibliography lists 273 reports, articles, and other documents introduced into the NASA scientific and technical information system in July 1978
Identification of cardiac signals in ambulatory ECG data
The Electrocardiogram (ECG) is the primary tool for monitoring heart function. ECG signals contain vital information about the heart which informs diagnosis and treatment of cardiac conditions. The diagnosis of many cardiac arrhythmias require long term and continuous ECG data, often while the participant engages in activity. Wearable ambulatory ECG (AECG) systems, such as the common Holter system, allow heart monitoring for hours or days. The technological trajectory of AECG systems aims towards continuous monitoring during a wide range of activities with data processed locally in real time and transmitted to a monitoring centre for further analysis. Furthermore, hierarchical decision systems will allow wearable systems to produce alerts or even interventions. These functions could be integrated into smartphones.A fundamental limitation of this technology is the ability to identify heart signal characteristics in ECG signals contaminated with high amplitude and non-stationary noise. Noise processing become more severe as activity levels increase, and this is also when many heart problems are present.This thesis focuses on the identification of heart signals in AECG data recorded during participant activity. In particular, it explored ECG filters to identify major heart conditions in noisy AECG data. Gold standard methods use Extended Kalman filters with extrapolation based on sum of Gaussian models. New methods are developed using linear Kalman filtering and extrapolation based on a sum of Principal Component basis signals. Unlike the gold standard methods, extrapolation is heartcycle by heartcycle. Several variants are explored where basic signals span one or two heartcycles, and applied to single or multi-channel ECG data.The proposed methods are extensively tested against standard databases or normal and abnormal ECG data and the performance is compared to gold standard methods. Two performance metrics are used: improvement in signal to noise ratio and the observability of clinically important features in the heart signal. In all tests the proposed method performs better, and often significantly better, than the gold standard methods. It is demonstrated that abnormal ECG signals can be identified in noisy AECG data
Aerospace medicine and biology: A continuing bibliography with indexes, supplement 130, July 1974
This special bibliography lists 291 reports, articles, and other documents introduced into the NASA scientific and technical information system in June 1974
Communications Biophysics
Contains research objectives, summary of research and reports on two research project.National Institutes of Health (Grant 5 PO1 GM14940-03)National Institutes of Health (Grant 5 TO1 GM01555-03)National Aeronautics and Space Administration (Grant NGL 22-009-304
Flexible Time Series Matching for Clinical and Behavioral Data
Time Series data became broadly applied by the research community in the last decades after
a massive explosion of its availability. Nonetheless, this rise required an improvement
in the existing analysis techniques which, in the medical domain, would help specialists
to evaluate their patients condition. One of the key tasks in time series analysis is pattern
recognition (segmentation and classification). Traditional methods typically perform subsequence
matching, making use of a pattern template and a similarity metric to search
for similar sequences throughout time series. However, real-world data is noisy and variable
(morphological distortions), making a template-based exact matching an elementary
approach. Intending to increase flexibility and generalize the pattern searching tasks
across domains, this dissertation proposes two Deep Learning-based frameworks to solve
pattern segmentation and anomaly detection problems.
Regarding pattern segmentation, a Convolution/Deconvolution Neural Network is
proposed, learning to distinguish, point-by-point, desired sub-patterns from background
content within a time series. The proposed framework was validated in two use-cases:
electrocardiogram (ECG) and inertial sensor-based human activity (IMU) signals. It outperformed
two conventional matching techniques, being capable of notably detecting the
targeted cycles even in noise-corrupted or extremely distorted signals, without using any
reference template nor hand-coded similarity scores.
Concerning anomaly detection, the proposed unsupervised framework uses the reconstruction
ability of Variational Autoencoders and a local similarity score to identify
non-labeled abnormalities. The proposal was validated in two public ECG datasets (MITBIH
Arrhythmia and ECG5000), performing cardiac arrhythmia identification. Results
indicated competitiveness relative to recent techniques, achieving detection AUC scores
of 98.84% (ECG5000) and 93.32% (MIT-BIH Arrhythmia).Dados de séries temporais tornaram-se largamente aplicados pela comunidade cientÃfica
nas últimas decadas após um aumento massivo da sua disponibilidade. Contudo, este
aumento exigiu uma melhoria das atuais técnicas de análise que, no domÃnio clÃnico, auxiliaria
os especialistas na avaliação da condição dos seus pacientes. Um dos principais
tipos de análise em séries temporais é o reconhecimento de padrões (segmentação e classificação).
Métodos tradicionais assentam, tipicamente, em técnicas de correspondência em
subsequências, fazendo uso de um padrão de referência e uma métrica de similaridade
para procurar por subsequências similares ao longo de séries temporais. Todavia, dados
do mundo real são ruidosos e variáveis (morfologicamente), tornando uma correspondência
exata baseada num padrão de referência uma abordagem rudimentar. Pretendendo
aumentar a flexibilidade da análise de séries temporais e generalizar tarefas de procura
de padrões entre domÃnios, esta dissertação propõe duas abordagens baseadas em Deep
Learning para solucionar problemas de segmentação de padrões e deteção de anomalias.
Acerca da segmentação de padrões, a rede neuronal de Convolução/Deconvolução
proposta aprende a distinguir, ponto a ponto, sub-padrões pretendidos de conteúdo de
fundo numa série temporal. O modelo proposto foi validado em dois casos de uso: sinais
eletrocardiográficos (ECG) e de sensores inerciais em atividade humana (IMU). Este superou
duas técnicas convencionais, sendo capaz de detetar os ciclos-alvo notavelmente,
mesmo em sinais corrompidos por ruÃdo ou extremamente distorcidos, sem o uso de
nenhum padrão de referência nem métricas de similaridade codificadas manualmente.
A respeito da deteção de anomalias, a técnica não supervisionada proposta usa a
capacidade de reconstrução dos Variational Autoencoders e uma métrica de similaridade
local para identificar anomalias desconhecidas. A proposta foi validada na identificação
de arritmias cardÃacas em duas bases de dados públicas de ECG (MIT-BIH Arrhythmia e
ECG5000). Os resultados revelam competitividade face a técnicas recentes, alcançando
métricas AUC de deteção de 93.32% (MIT-BIH Arrhythmia) e 98.84% (ECG5000)
Deep Learning in Cardiology
The medical field is creating large amount of data that physicians are unable
to decipher and use efficiently. Moreover, rule-based expert systems are
inefficient in solving complicated medical tasks or for creating insights using
big data. Deep learning has emerged as a more accurate and effective technology
in a wide range of medical problems such as diagnosis, prediction and
intervention. Deep learning is a representation learning method that consists
of layers that transform the data non-linearly, thus, revealing hierarchical
relationships and structures. In this review we survey deep learning
application papers that use structured data, signal and imaging modalities from
cardiology. We discuss the advantages and limitations of applying deep learning
in cardiology that also apply in medicine in general, while proposing certain
directions as the most viable for clinical use.Comment: 27 pages, 2 figures, 10 table
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