Machine Learning Framework to Identify Individuals at Risk of Rapid Progression of Coronary Atherosclerosis: From the PARADIGM Registry.

Background Rapid coronary plaque progression (RPP) is associated with incident cardiovascular events. To date, no method exists for the identification of individuals at risk of RPP at a single point in time. This study integrated coronary computed tomography angiography-determined qualitative and quantitative plaque features within a machine learning (ML) framework to determine its performance for predicting RPP. Methods and Results Qualitative and quantitative coronary computed tomography angiography plaque characterization was performed in 1083 patients who underwent serial coronary computed tomography angiography from the PARADIGM (Progression of Atherosclerotic Plaque Determined by Computed Tomographic Angiography Imaging) registry. RPP was defined as an annual progression of percentage atheroma volume ≥1.0%. We employed the following ML models: model 1, clinical variables; model 2, model 1 plus qualitative plaque features; model 3, model 2 plus quantitative plaque features. ML models were compared with the atherosclerotic cardiovascular disease risk score, Duke coronary artery disease score, and a logistic regression statistical model. 224 patients (21%) were identified as RPP. Feature selection in ML identifies that quantitative computed tomography variables were higher-ranking features, followed by qualitative computed tomography variables and clinical/laboratory variables. ML model 3 exhibited the highest discriminatory performance to identify individuals who would experience RPP when compared with atherosclerotic cardiovascular disease risk score, the other ML models, and the statistical model (area under the receiver operating characteristic curve in ML model 3, 0.83 [95% CI 0.78-0.89], versus atherosclerotic cardiovascular disease risk score, 0.60 [0.52-0.67]; Duke coronary artery disease score, 0.74 [0.68-0.79]; ML model 1, 0.62 [0.55-0.69]; ML model 2, 0.73 [0.67-0.80]; all P<0.001; statistical model, 0.81 [0.75-0.87], P=0.128). Conclusions Based on a ML framework, quantitative atherosclerosis characterization has been shown to be the most important feature when compared with clinical, laboratory, and qualitative measures in identifying patients at risk of RPP

A validation of mobile sensing actigraphy devices for generating a biomechanical model of posture

Mobile sensing actigraphy was tested and validated as a modality for computing dynamic posturography. Twelve healthy volunteer subjects (6 male) were administered risperidone and assessed for postural stability using a NeuroCom® Balance Master system and BioSensics® mobile sensors at baseline, 2 hours, 6 hours, and 24 hours post-dose. A strong positive correlation was shown between BioSensics and Balance Master systems in a modified Sensory Organization Task, with Pearson’s r = 0.76, p < 0.001 on composite equilibrium scores. Strong to moderate correlations during the same task showed r = 0.48, p < 0.001 to r = 0.74, p < 0.001. Mobile sensing actigraphy may be a viable alternative to force plate posturography in assessing drug-induced postural instability

Biopsychological traits of Sasang typology based on Sasang personality questionnaire and body mass index

BACKGROUND: The purpose of present study was to examine biological and psychological characteristics of people according to the Sasang typology, which is popular in Korea. We evaluated the Sasang Personality Questionnaire (SPQ) as a measure of temperament, and Body Mass Index (BMI) as a measure of the somatic properties of each Sasang type. METHODS: Subjects were 2506 (877 males, 1629 females) outpatients between the ages of 20 through 70 who requested traditional medical assessment and treatment in Korea. The structural validity of the SPQ was examined and its correlation with BMI was analyzed. The SPQ and BMI measures of each Sasang type across age and gender were presented and their differences were analyzed with Analysis of Variance. RESULTS: Confirmatory factor analysis and path analysis identified an acceptable three-factor structure of the SPQ measuring differences in individual’s behavior, emotion, and cognition. SPQ scores (29.71 ± 1.00, 28.29 ± 0.19 and 26.14 ± 0.22) and BMI scores (22.92 ± 0.09, 25.56 ± 0.10 and 21.44 ± 0.10) were significantly (p < 0.001) different among So-Yang, Tae-Eum and So-Eum Sasang types, respectively. CONCLUSIONS: The results showed that the SPQ and BMI is a reliable measure for quantifying the biopsychological characteristics of each types, and useful for guiding personalized and type-specific treatment with medical herbs and acupuncture

Projection of Diabetes Population Size and Associated Economic Burden through 2030 in Iran : Evidence from Micro-Simulation Markov Model and Bayesian Meta-Analysis

Acknowledgments The authors would like to thank kindly all advisors and colleagues, for their valuable technical support. We would like to thank you Ms Laura Marie Dysart for editing the paper.Peer reviewedPublisher PD

Abstracts from the Twelfth Annual Conference on Ethnic and Minority Studies

In an attempt to record a sense of the formal sessions of the 1984 Conference, we asked the Chairs to assemble abstracts and discussant comments for their sessions. Although we are pleased with a response greater than in 1983, we are aiming for one hundred percent in 1985

The Road Ahead for the U.S. Auto Industry

[Excerpt] In 2004, U.S. light vehicle sales were up slightly, reversing a moderate slide that began in 2001. The 1.3 percent gain brought the market total to 16.8 million units, approximately the same level as 2002, and the fourth highest sales on record. The trend, which began in 2001 of offering low or no cost financing along with high rebates has cast a cloud over the otherwise sunny sales outcome for the year. American consumers have continued the long-term shift towards a preference for light trucks over passenger cars. Trucks passed cars in 2001, hitting over half the market for the first time that year. In 2004, light trucks accounted for over 55 percent of the U.S. passenger vehicle market. Light truck sales reached 9.3 million units, up 3.6 percent over 2003. Passenger car sales were down 1.4 percent compared to 2003, reaching only 7.5 million units

Кибербезопасность в образовательных сетях

The paper discusses the possible impact of digital space on a human, as well as human-related directions in cyber-security analysis in the education: levels of cyber-security, social engineering role in cyber-security of education, “cognitive vaccination”. “A Human” is considered in general meaning, mainly as a learner. The analysis is provided on the basis of experience of hybrid war in Ukraine that have demonstrated the change of the target of military operations from military personnel and critical infrastructure to a human in general. Young people are the vulnerable group that can be the main goal of cognitive operations in long-term perspective, and they are the weakest link of the System.У статті обговорюється можливий вплив цифрового простору на людину, а також пов'язані з людиною напрямки кібербезпеки в освіті: рівні кібербезпеки, роль соціального інжинірингу в кібербезпеці освіти, «когнітивна вакцинація». «Людина» розглядається в загальному значенні, головним чином як та, що навчається. Аналіз надається на основі досвіду гібридної війни в Україні, яка продемонструвала зміну цілей військових операцій з військовослужбовців та критичної інфраструктури на людину загалом. Молодь - це вразлива група, яка може бути основною метою таких операцій в довгостроковій перспективі, і вони є найслабшою ланкою системи.В документе обсуждается возможное влияние цифрового пространства на человека, а также связанные с ним направления в анализе кибербезопасности в образовании: уровни кибербезопасности, роль социальной инженерии в кибербезопасности образования, «когнитивная вакцинация». «Человек» рассматривается в общем смысле, в основном как ученик. Анализ представлен на основе опыта гибридной войны в Украине, которая продемонстрировала изменение цели военных действий с военного персонала и критической инфраструктуры на человека в целом. Молодые люди являются уязвимой группой, которая может быть главной целью когнитивных операций в долгосрочной перспективе, и они являются самым слабым звеном Систем

PRE working paper series : numbers 723 to 761

This paper contains a numerical listing of working papers produced by the Policy, Planning, and External Affairs Complex. Each citation contains a brief abstract, and the contact point for the paper.Environmental Economics&Policies,Health Monitoring&Evaluation,Banks&Banking Reform,Health Economics&Finance,Economic Theory&Research