4 research outputs found
Graph networks for molecular design
Deep learning methods applied to chemistry can be used to accelerate the discovery of new molecules. This work introduces GraphINVENT, a platform developed for graph-based molecular design using graph neural networks (GNNs). GraphINVENT uses a tiered deep neural network architecture to probabilistically generate new molecules a single bond at a time. All models implemented in GraphINVENT can quickly learn to build molecules resembling the training set molecules without any explicit programming of chemical rules. The models have been benchmarked using the MOSES distribution-based metrics, showing how GraphINVENT models compare well with state-of-the-art generative models. This work compares six different GNN-based generative models in GraphINVENT, and shows that ultimately the gated-graph neural network performs best against the metrics considered here
A Systematic Survey on Deep Generative Models for Graph Generation
Graphs are important data representations for describing objects and their
relationships, which appear in a wide diversity of real-world scenarios. As one
of a critical problem in this area, graph generation considers learning the
distributions of given graphs and generating more novel graphs. Owing to its
wide range of applications, generative models for graphs have a rich history,
which, however, are traditionally hand-crafted and only capable of modeling a
few statistical properties of graphs. Recent advances in deep generative models
for graph generation is an important step towards improving the fidelity of
generated graphs and paves the way for new kinds of applications. This article
provides an extensive overview of the literature in the field of deep
generative models for the graph generation. Firstly, the formal definition of
deep generative models for the graph generation as well as preliminary
knowledge is provided. Secondly, two taxonomies of deep generative models for
unconditional, and conditional graph generation respectively are proposed; the
existing works of each are compared and analyzed. After that, an overview of
the evaluation metrics in this specific domain is provided. Finally, the
applications that deep graph generation enables are summarized and five
promising future research directions are highlighted