Computational simulations demonstrate altered wall shear stress in aortic coarctation patients previously treated by resection with end-to-end anastomosis

Background.  Atherosclerotic plaque in the descending thoracic aorta (dAo) is related to altered wall shear stress (WSS) for normal patients. Resection with end-to-end anastomosis (RWEA) is the gold standard for coarctation of the aorta (CoA) repair, but may lead to altered WSS indices that contribute to morbidity. Methods.  Computational fluid dynamics (CFD) models were created from imaging and blood pressure data for control subjects and age- and gender-matched CoA patients treated by RWEA (four males, two females, 15 ± 8 years). CFD analysis incorporated downstream vascular resistance and compliance to generate blood flow velocity, time-averaged WSS (TAWSS), and oscillatory shear index (OSI) results. These indices were quantified longitudinally and circumferentially in the dAo, and several visualization methods were used to highlight regions of potential hemodynamic susceptibility. Results.  The total dAo area exposed to subnormal TAWSS and OSI was similar between groups, but several statistically significant local differences were revealed. Control subjects experienced left-handed rotating patterns of TAWSS and OSI down the dAo. TAWSS was elevated in CoA patients near the site of residual narrowings and OSI was elevated distally, particularly along the left dAo wall. Differences in WSS indices between groups were negligible more than 5 dAo diameters distal to the aortic arch. Conclusions.  Localized differences in WSS indices within the dAo of CoA patients treated by RWEA suggest that plaque may form in unique locations influenced by the surgical repair. These regions can be visualized in familiar and intuitive ways allowing clinicians to track their contribution to morbidity in longitudinal studies

MOHIST APPROACH TO THE RULE-FOLLOWING PROBLEM

The Mohist conceives the dao-following issue as how we can put dao in words and speeches into practice. The dao-following issue is the Mohist counterpart of Wittgenstein\u27s rule-following problem. This paper aims to shed light on the rule-following issue in terms of the Mohist answer to the dao-following problem. The early Mohist takes fa(法, standard)and the later Mohist takes lei(類, analogy)as the key to the dao-following issue. I argue that the way of fa is not viable. Fa comes in various forms, but all of them are regarded as being cut off from everyday life and therefore subject to various interpretations and, hence, incapable of action-guiding. On the other hand, the Mohist lei represents a kind of life world action drama. A lei situates various elements of action in the context of an everyday life scene. I argue that lei is more qualified than fa in answering to the dao-following issue. I also show that lei substantializes what McDowell calls the course between a Scylla and a Charybdis hinted in terms of Wittgenstein\u27s idea of custom, practice, and institution in regard to the rule-following problem

Critical analysis of the philosophical conception of verification of being/the self in Heidegger's “Being and Time” against dao/the other in Laozi's Daodejing.

That dao and being are correct as written about by Laozi and Heidegger respectively is exposed through eight perspectives

Quantification of Local Hemodynamic Alterations Caused by Virtual Implantation of Three Commercially Available Stents for the Treatment of Aortic Coarctation

Patients with coarctation of the aorta (CoA) are prone to morbidity including atherosclerotic plaque that has been shown to correlate with altered wall shear stress (WSS) in the descending thoracic aorta (dAo). We created the first patient-specific computational fluid dynamics (CFD) model of a CoA patient treated by Palmaz stenting to date, and compared resulting WSS distributions to those from virtual implantation of Genesis XD and modified NuMED CP stents, also commonly used for CoA. CFD models were created from magnetic resonance imaging, fluoroscopy and blood pressure data. Simulations incorporated vessel deformation, downstream vascular resistance and compliance to match measured data and generate blood flow velocity and time-averaged WSS (TAWSS) results. TAWSS was quantified longitudinally and circumferentially in the stented region and dAo. While modest differences were seen in the distal portion of the stented region, marked differences were observed downstream along the posterior dAo and depended on stent type. The Genesis XD model had the least area of TAWSS values exceeding the threshold for platelet aggregation in vitro, followed by the Palmaz and NuMED CP stents. Alterations in local blood flow patterns and WSS imparted on the dAo appear to depend on the type of stent implanted for CoA. Following confirmation in larger studies, these findings may aid pediatric interventional cardiologists in selecting the most appropriate stent for each patient, and ultimately reduce long-term morbidity following treatment for CoA by stenting

Spectropolarimetry with the DAO 1.8-m telescope

The fast-switching DAO spectropolarimeter mounted on the 1.8-m Plaskett telescope started operation in 2007. Almost 14,000 medium-resolution (R=15,000) polarimetric spectra of 65 O - F type stars have been obtained since then in the course of three ongoing projects: the DAO Magnetic Field Survey, supporting observations for the CFHT MiMeS survey, and an investigation of the systematic differences between the observed longitudinal field measured with the Hbeta line and metallic lines. The projects are briefly described here. The current status as well as some results are presented.Comment: "Magnetic Stars", Proceedings of the International Conference, Nizhny Arkhyz, 27 August - 1 September 201

Discovery of the Host Cluster for the Fundamental Cepheid Calibrator Zeta Gem

New and existing CORAVEL, UBVJHKs, HST, HIP/Tycho, ARO, KPNO, and DAO observations imply that the fundamental Cepheid calibrator Zeta Gem is a cluster member. The following parameters were inferred for Zeta Gem from cluster membership and are tied to new spectral classifications (DAO) established for 26 nearby stars (e.g., HD53588/B7.5IV, HD54692/B9.5IV): E(B-V)=0.02+-0.02, log t=7.85+-0.15, and d=355+-15 pc. The mean distance to Zeta Gem from cluster membership and six recent estimates (e.g., IRSB) is d=363+-9(se)+-26(sd) pc. The results presented here support the color-excess and HST parallax derived for the Cepheid by Benedict et al. (2007). Forthcoming precise proper motions (DASCH) and Chandra/XMM-Newton observations of the broader field may be employed to identify cluster members, bolster the cluster's existence, and provide stronger constraints on the Cepheid's fundamental parameters.Comment: To appear in ApJ Letter

El Niño and the delayed action oscillator

We study the dynamics of the El Niño phenomenon using the mathematical model of delayedaction oscillator (DAO). Topics such as the influence of the annual cycle, global warming, stochastic influences due to weather conditions and even off-equatorial heat-sinks can all be discussed using only modest analytical and numerical resources. Thus the DAO allows for a pedagogical introduction to the science of El Niño and La Niña while at the same time avoiding the need for large-scale computing resources normally associated with much more sophisticated coupled atmosphere-ocean general circulation models. It is an approach which is ideally suited for student projects both at high school and undergraduate level

Critical analysis of the philosophical conception of dao in Laozi's Daodejing and being in Heidegger's “Being and Time”

That dao and being are correct as written about by Laozi and Heidegger respectively is exposed through eight focal points