PENGARUH BUBUK KUNYIT HITAM (Curcuma caesia) TERHADAP PENURUNAN KADAR GLUKOSA DARAH PADA MENCIT (Mus musculus L.) SWISS WEBSTER JANTAN YANG MENGALAMI HIPERGLIKEMIA

Kegemukan merupakan keadaan di mana berat badan berada melebihi berat ideal yang disebabkan penumpukan zat gizi terutama karbohidrat, protein dan lemak. Obesitas dapat menyebabkan berlebihnya kadar glukosa dalam darah. Kunyit hitam (Curcuma caesia) selain memiliki kandungan fitokimia kurkumin, juga memiliki kandungan flavonoid, alkaloid dan tannin yang diduga kandungan tersebut mampu menurunkan kadar glukosa darah. Tujuan dari penelitian ini adalah mengetahui pengaruh bubuk kunyit hitam (Curcuma caesia) terhadap penurunan kadar glukosa darah Mus musculus L. Swiss Webster jantan yang telah diberi pakan berkarbohidrat tinggi. Dosis bubuk kunyit hitam (Curcuma caesia) yang digunakan adalah 15 mg/30 g BB/hari, 22,5 mg/30 g BB/hari dan 30 mg/30 g BB/hari. Hasil penelitian menunjukkan dosis pemberian bubuk kunyit hitam (Curcuma caesia) yang diberikan, menunujukkan penurunan kadar glukosa darah sebanyak 24.6 untuk dosis 15 mg/30 g BB/hari, dosis 22,5 mg/30 g BB/hari menununjukkan penurunan kadar glukosa darah sebanyak 56.8 dan pada dosis 30 mg//30 g BB/hari penurunan kadar glukosa darah sebanyak 21.5. Dapat disimpulkan bahwa secara keseluruhan dosis yang diberikan memperlihatkan adanya pengaruh terhadap kadar glukosa darah mencit, namun dosis yang menunjukkan penurunan kadar glukosa darah tertinggi adalah pada dosis 22.5 mg. Kata Kunci : Kegemukan, hiperglikemia, kadar glukosa darah, kunyit hitam (Curcuma caesia)

Curcuma Domestica Volatile Oil (Curcuma Domestica, Val) as Anti Inflamation Agent on Gout Arthritis Patient with High Purin Diet

Increased concentrations of crystal monosodium urea at joint and soft tissue represent induced of inflammation at gout arthritis (GA). Incidence and prevalence GA disseminate wide in developed countries in Asian range from 2-15% and In Indonesia, GA prevalence was 29% and mostly found in Minahasa, Toraja, and Batak ethnics. This research was aimed to analyse application of curcuma domestica volatile oil as anti inflammation agent on gout arthritis patient who has high purin diet and to assess specific cellular mediator Tumor Necrosis Factor-α (TNF-α). The design of the study was randomized pretest-posttest control group design with single blind treatment. The GCMS test was performed to identify active component in volatile oil. The sample was the new gout arthritis patient in Haji Public Hospital Surabaya. For a week, treatment group was assigned with volatile oil with dose 25 mg/kg body weight and the control group was given indometasin 150 mg/kg body weight. Blood samples were taken before and after treatment. Volatile oil of curcuma domestica (Curcuma domestica, val) has four fraction of active component. There was decreasing in blood urea level in treatment group (p = 0.001) and control group (p = 0.007). Both in control and treatment group, there was also decreasing in TNF-α, however it was not statistically significant

Documentation of ethno-medicinal practices: A case study on tribal forest fringe dwellers of Terai West Bengal in India

The ethno-medicinal practices were documented which were being used by tribal population dwelling forest fringe areas of Terai zone of West Bengal, India on under exploited, non conventional, traditional and indigenous plant species for the sustainable utilization of these resources to cure day to day ailments. A total number of forty seven medicinal plant species belonging to 25 families were documented during the survey period 2012-13, which was used in curing many diseases. Among the families, Euphorbiaceae, Zingeberaceae and Leguminosae were the dominant families that represented four species each. Herb was the highest proportion of plant species 18 (38%) followed by 15 tree species (32%), 8 species of shrubs (17%) and rest were climbers and fern. It was observed that the tribal forest fringe communities of the Terai zone of the West Bengal have a good ethno-medicinal knowledge of using plant resources and developed their own traditional practices to cure day to day diseases

Phytotherapy of nephrotoxicity-induced by cancer drugs: An updated review

Context: Kidney is one of the vital organs maintaining homeostasis of body and thus dysfunction of kidney affects quality of life and health severely. Anticancer drugs, particularly chemotherapeutic agents, cause high toxicity leading kidney dysfunction and irreparable kidney injury. Therefore, attention has recently been paid to seeking out alternatives such as nature-based drugs that are effective but less toxic. In this regard, this systematic review article is to report and introduce the most important medicinal plants and their derivatives that are used to reduce anticancer drug-induced nephrotoxicity. Evidence Acquisitions: The word nephrotoxicity alongside the words cancer or chemotherapy in combination with some herbal terms such as medicinal plant, plants, herbs, and extracts were administered to search for relevant publications indexed in PubMed. Results: According to this study, 16 medicinal plants, 12 plant-based derivatives, and three traditional plant-based formulations were found to help control and modulate anticancer drug-induced nephrotoxicity indices. Conclusions: Anticancer drugs cause nephrotoxicity through activating pathways of oxidative stress, damage-associated molecular patterns (DAMPs) production, inflammatory processes, and cell apoptosis, while medicinal plants and their derivatives can cause reduction in nephrotoxicity and anticancer drugs side effects via their antioxidant and anti-inflammatory properties. © 2017 The Author(s); Published by Society of Diabetic Nephropathy Prevention

Analisis Kemiripan 20 Aksesi Temu Ireng (Curcuma Aeruginosa Roxb.) Berdasarkan Warna Rimpang, Hasil Ekstrak, dan Kandungan Fitokimia

Curcuma aeruginosa Roxb., popularly known as “temu ireng”, is considered as a potential source of medicinal plant for pharmacological activities. However, varieties of C. aeruginosa are still limited in Indonesia so it needs more accessions for improvement and development of new varieties. Rhizome colors, phytochemical contents and extract yield from 20 promising lines of C. aeruginosa were investigated by qualitative method for rhizome colors and phytochemical contents, and maceration method using 70% ethanol for yield extract. Similarity analysis was used for cluster analysis based on rhizome colors, phytochemical contents and yield extract. Blue was the color characterization of rhizome C. aeruginosa. The extract yield for 20 promising lines of C. aeruginosa varied from 7.92 to 19.71%, with KN and BH promising lines having the lowest and highest value, respectively. All promising lines of C. aeruginosa contain saponin and triterpenoid. Based on similarity analysis, all promising lines could be divided into 3 clusters. Cluster I consisted of 14 promising lines i.e. WG, SH, KA, GD, BH, KP, NW, PW, MB, PR, PT, KN, MD, and PK. Cluster II consisted of 4 promising lines i.e. LC, CB, KL, and GK. Cluster III consisted of 2 promising lines i.e. KD and SG

EFFICACY AND TOLERABILITY OF A NOVEL FORMULATION FOR WEIGHT MANAGEMENT IN OBESE SUBJECTS: A RANDOMIZED, DOUBLE BLIND, PLACEBO CONTROLLED, CLINICAL STUDY

Obesity is a complex interplay between environmental and genetic factors, is also associated with significant morbidity and mortality. The primary objective of the present study was to evaluate the efficacy and safety of Calebin A (standardized extract of Curcuma caesia) in the management of weight in obese or overweight individuals. A randomized, mono-centric, double-blind, placebo-controlled, clinical study was conducted by administering Calebin A (standardized extract of Curcuma caesia) capsules (25 mg, one capsule twice a day) and indistinguishable placebo capsules as daily supplements to 40 overweight and obese subjects for 90 days. The study participants were divided in 1:1 ratio to receive either Calebin A (standardized extract of Curcuma caesia) (n = 20) or placebo (n = 20).Efficacy was assessed by measuring body weight, body mass index, leptin, adiponectin levels, total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides and Hs-CRP. Safety was assessed by evaluating safety parameters (vital signs and laboratory investigations) and monitoring adverse events.After 90 days, significant reduction in body weight (P< 0.0001) and body mass index (P < 0.0001) were observed in the Calebin A (standardized extract of Curcuma caesia) group compared with placebo. Additionally, significant change in serum biomarkers was observed between Calebin A (standardized extract of Curcuma caesia) and placebo groups from baseline to final visits. Adverse events were mild and were unrelated to the investigational products. Supplementation with Calebin A (standardized extract of Curcuma caesia) resulted in significant decrease in weight loss than placebo over 90 days. It was safe and well tolerated by all subjects

Ethno-Medico-Botanical Studies From Rayalaseema Region of Southern Eastern Ghats, Andhra Pradesh, India

This paper deals with Ethno- Medico botanical Studies of Rayalaseema Region, Andhra Pradesh, India. An ethno-botanical survey was carried out in Seshachalam hills of Chittoor District, Palakondas and Lankamalais of Kadapa District, Errmalais and Nallamalai hills of Kurnool District and some other isolated hill ranges in Ananthapur District are Kalasamudram-Nigidi forest range, Amagondapalem hills and Kikati forest

Ethnomedicinal plant use by Lepcha tribe of Dzongu valley, bordering Khangchendzonga Biosphere Reserve, in North Sikkim, India

Lepcha is the oldest and the first tribe reported from Sikkim, India; majority of its population inhabiting in Dzongu valley, an officially demarcated reserve for Lepcha community, bordering Khangchendzonga Biosphere Reserve, in north district. Lepchas of Dzongu are known for their retention of rich cultural heritage. In view of the on-going cultural and economic changes brought in by the process of globalization, the immediate need was felt to document in details the under-explored ethnomedicinal practices of Lepchas of Dzongu valley. This paper reports 118 species, belonging to 71 families and 108 genera, under ethnomedicinal utility by the Lepchas for curing approximately 66 ailments, which could be grouped under 14 broad categories. Zingiberaceae appeared as the most used family (8 species and 5 genera). As per use pattern, maximum of 30.50% species are to cure stomach related disorders/ailments, followed by 19.49% for curing cut, wounds, inflammation, sprains and joint pains. Administration of medicine orally is recorded in 75% cases. Root and rhizome harvesting targeted 30 species. The changing scenario over time both at socio-cultural front and passing traditional knowledge interests from older to younger generation and rich ethnomicinal wealth of the oldest tribe of Sikkim are discussed in the light of conservation strategies and techniques to adopt

COMPARATIVE ASSESSMENT OF IN VITRO ANTIMICROBIAL ACTIVITY OF CURCUMA CAESIA ROXB. AND CURCUMA AMADA ROXB

Objective: The aim of the present study was to compare the in vitro antimicrobial activity of Curcuma caesia Roxb. and Curcuma amada Roxb. family Zingiberaceae. Both plants have been used traditionally for curing a number of diseases and ailments. The plants have been specifically used in skin problems and inflammatory conditions.Methods: Each plant material was extracted with dichloromethane (DCM) and ethanol. All extracts were subjected to preliminary phytochemical screening. The antibacterial activity of the extracts was tested against two Gram-positive (Staphylococcus aureus, Streptococcus pyogenes), and two Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa) using the cup-plate method. The standard drug used was ofloxacin (0.2 ml) at a concentration of 5 mg/ml. The antifungal activity was tested against Aspergillus fumigatus, and Candida albicans using the cup-plate method and clotrimazole (10 mg/ml) was taken as standard reference.Results: Phytochemical screening performed on the extracts has shown the presence of various constituents such as glycosides, carbohydrates, saponins, phytosterols, resins, flavonoids, and diterpenoids. On comparing both species, C. amada was found to be stronger growth inhibitor against both Gram-positive and Gram-negative strains. C. caesia ethanol extract at a dose of 200 mg/ml was most effective and C. amada DCM extract 100 mg/ml was least effective in case of antifungal activity against C. albicans. In case of A. fumigatus, C. caesia DCM extract 100 mg/ml was least effective and C. caesia ethanol extract 200 mg/ml was most effective.Conclusion: The present study provides the information on phytochemical screening and antimicrobial activities of extracts prepared from two plants of family Zingiberaceae, i.e., C. caesia Roxb. and C. amada Roxb