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Cooperative binary-real coded genetic algorithms for generating and adapting artificial neural networks Received: j / Accepted: j Ó Springer-Verlag London Limited 2003 Abstract This paper describes a genetic system for designing and training feed-forward artificial neural networks to solve any problem presented as a set of training patterns. This system, called GANN, employs two interconnected genetic algorithms that work parallelly to design and train the better neural network that solves the problem. Designing neural architectures is performed by a genetic algorithm that uses a new indirect binary codification of the neural connections based on an algebraic structure defined in the set of all possible architectures that could solve the problem. A crossover operation, known as Hamming crossover, has been designed to obtain better performance when working with this type of codification. Training neural networks is also accomplished by genetic algorithms but, this time, real number codification is employed. To do so, morphological crossover operation has been developed inspired on the mathematical morphology theory. Experimental results are reported from the application of GANN to the breast cancer diagnosis within a complete computer-aided diagnosis system