3,149 research outputs found

    3D Printing of Dietary Products for the Management of Inborn Errors of Intermediary Metabolism in Pediatric Populations

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    © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY), https://creativecommons.org/licenses/by/4.0/The incidence of Inborn Error of Intermediary Metabolism (IEiM) diseases may be low, yet collectively, they impact approximately 6–10% of the global population, primarily affecting children. Precise treatment doses and strict adherence to prescribed diet and pharmacological treatment regimens are imperative to avert metabolic disturbances in patients. However, the existing dietary and pharmacological products suffer from poor palatability, posing challenges to patient adherence. Furthermore, frequent dose adjustments contingent on age and drug blood levels further complicate treatment. Semi-solid extrusion (SSE) 3D printing technology is currently under assessment as a pioneering method for crafting customized chewable dosage forms, surmounting the primary limitations prevalent in present therapies. This method offers a spectrum of advantages, including the flexibility to tailor patient-specific doses, excipients, and organoleptic properties. These elements are pivotal in ensuring the treatment’s efficacy, safety, and adherence. This comprehensive review presents the current landscape of available dietary products, diagnostic methods, therapeutic monitoring, and the latest advancements in SSE technology. It highlights the rationale underpinning their adoption while addressing regulatory aspects imperative for their seamless integration into clinical practice.Peer reviewe

    Africa's digital future

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    The main thrust of this book is to examine whether Africa is in a position to benefit from the digital age, given the continent’s many development challenges and slow adoption of digital technologies. While there is substantial literature on the digital economy and the quickening pace of the Fourth Industrial Revolution (4IR), comparatively little research has been conducted on what the digital age means for Africa. This book aims to close this research gap by using various qualitative and quantitative research methodologies to arrive at a cross-section of original findings and perspectives on how Africa can capitalise on the benefits of digital developments, including their potential to create jobs and bring about more inclusive growth. The book’s main contribution is its coverage of a range of topics that will affect Africa’s digital future, including industrialisation, global value chains, transport and logistics, trade facilitation, labour-market dynamics, employment and education. The theme of digital trade forms a backdrop to many of the chapters, along with references to the COVID-19 pandemic. The book acknowledges that although African countries should learn from international best practices, they need to chart their own course according to their own particular circumstances. By adopting a digital mindset, countries should be able to diversify economically and extend their market reach across the continent. Furthermore, while Africa should be looking to the future and determining how digital technologies can become effective tools of sustainable development, the continent has much catching up to do

    Design Transactions

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    Design Transactions presents the outcome of new research to emerge from ‘Innochain’, a consortium of six leading European architectural and engineering-focused institutions and their industry partners. The book presents new advances in digital design tooling that challenge established building cultures and systems. It offers new sustainable and materially smart design solutions with a strong focus on changing the way the industry thinks, designs, and builds our physical environment. Divided into sections exploring communication, simulation and materialisation, Design Transactions explores digital and physical prototyping and testing that challenges the traditional linear construction methods of incremental refinement. This novel research investigates ‘the digital chain’ between phases as an opportunity for extended interdisciplinary design collaboration. The highly illustrated book features work from 15 early-stage researchers alongside chapters from world-leading industry collaborators and academics

    Design Transactions: Rethinking Information for a New Material Age

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    Design Transactions presents the outcome of new research to emerge from ‘Innochain’, a consortium of six leading European architectural and engineering-focused institutions and their industry partners. The book presents new advances in digital design tooling that challenge established building cultures and systems. It offers new sustainable and materially smart design solutions with a strong focus on changing the way the industry thinks, designs, and builds our physical environment. Divided into sections exploring communication, simulation and materialisation, Design Transactions explores digital and physical prototyping and testing that challenges the traditional linear construction methods of incremental refinement. This novel research investigates ‘the digital chain’ between phases as an opportunity for extended interdisciplinary design collaboration. The highly illustrated book features work from 15 early-stage researchers alongside chapters from world-leading industry collaborators and academics

    Africa's digital future

    Get PDF
    The main thrust of this book is to examine whether Africa is in a position to benefit from the digital age, given the continent’s many development challenges and slow adoption of digital technologies. While there is substantial literature on the digital economy and the quickening pace of the Fourth Industrial Revolution (4IR), comparatively little research has been conducted on what the digital age means for Africa. This book aims to close this research gap by using various qualitative and quantitative research methodologies to arrive at a cross-section of original findings and perspectives on how Africa can capitalise on the benefits of digital developments, including their potential to create jobs and bring about more inclusive growth. The book’s main contribution is its coverage of a range of topics that will affect Africa’s digital future, including industrialisation, global value chains, transport and logistics, trade facilitation, labour-market dynamics, employment and education. The theme of digital trade forms a backdrop to many of the chapters, along with references to the COVID-19 pandemic. The book acknowledges that although African countries should learn from international best practices, they need to chart their own course according to their own particular circumstances. By adopting a digital mindset, countries should be able to diversify economically and extend their market reach across the continent. Furthermore, while Africa should be looking to the future and determining how digital technologies can become effective tools of sustainable development, the continent has much catching up to do
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