22,135 research outputs found
A Statistical Model for Simultaneous Template Estimation, Bias Correction, and Registration of 3D Brain Images
Template estimation plays a crucial role in computational anatomy since it
provides reference frames for performing statistical analysis of the underlying
anatomical population variability. While building models for template
estimation, variability in sites and image acquisition protocols need to be
accounted for. To account for such variability, we propose a generative
template estimation model that makes simultaneous inference of both bias fields
in individual images, deformations for image registration, and variance
hyperparameters. In contrast, existing maximum a posterori based methods need
to rely on either bias-invariant similarity measures or robust image
normalization. Results on synthetic and real brain MRI images demonstrate the
capability of the model to capture heterogeneity in intensities and provide a
reliable template estimation from registration
Part-to-whole Registration of Histology and MRI using Shape Elements
Image registration between histology and magnetic resonance imaging (MRI) is
a challenging task due to differences in structural content and contrast. Too
thick and wide specimens cannot be processed all at once and must be cut into
smaller pieces. This dramatically increases the complexity of the problem,
since each piece should be individually and manually pre-aligned. To the best
of our knowledge, no automatic method can reliably locate such piece of tissue
within its respective whole in the MRI slice, and align it without any prior
information. We propose here a novel automatic approach to the joint problem of
multimodal registration between histology and MRI, when only a fraction of
tissue is available from histology. The approach relies on the representation
of images using their level lines so as to reach contrast invariance. Shape
elements obtained via the extraction of bitangents are encoded in a
projective-invariant manner, which permits the identification of common pieces
of curves between two images. We evaluated the approach on human brain
histology and compared resulting alignments against manually annotated ground
truths. Considering the complexity of the brain folding patterns, preliminary
results are promising and suggest the use of characteristic and meaningful
shape elements for improved robustness and efficiency.Comment: Paper accepted at ICCV Workshop (Bio-Image Computing
Anatomical landmark based registration of contrast enhanced T1-weighted MR images
In many problems involving multiple image analysis, an im- age registration step is required. One such problem appears in brain tumor imaging, where baseline and follow-up image volumes from a tu- mor patient are often to-be compared. Nature of the registration for a change detection problem in brain tumor growth analysis is usually rigid or affine. Contrast enhanced T1-weighted MR images are widely used in clinical practice for monitoring brain tumors. Over this modality, con- tours of the active tumor cells and whole tumor borders and margins are visually enhanced. In this study, a new technique to register serial contrast enhanced T1 weighted MR images is presented. The proposed fully-automated method is based on five anatomical landmarks: eye balls, nose, confluence of sagittal sinus, and apex of superior sagittal sinus. Af- ter extraction of anatomical landmarks from fixed and moving volumes, an affine transformation is estimated by minimizing the sum of squared distances between the landmark coordinates. Final result is refined with a surface registration, which is based on head masks confined to the sur- face of the scalp, as well as to a plane constructed from three of the extracted features. The overall registration is not intensity based, and it depends only on the invariant structures. Validation studies using both synthetically transformed MRI data, and real MRI scans, which included several markers over the head of the patient were performed. In addition, comparison studies against manual landmarks marked by a radiologist, as well as against the results obtained from a typical mutual information based method were carried out to demonstrate the effectiveness of the proposed method
WxBS: Wide Baseline Stereo Generalizations
We have presented a new problem -- the wide multiple baseline stereo (WxBS)
-- which considers matching of images that simultaneously differ in more than
one image acquisition factor such as viewpoint, illumination, sensor type or
where object appearance changes significantly, e.g. over time. A new dataset
with the ground truth for evaluation of matching algorithms has been introduced
and will be made public.
We have extensively tested a large set of popular and recent detectors and
descriptors and show than the combination of RootSIFT and HalfRootSIFT as
descriptors with MSER and Hessian-Affine detectors works best for many
different nuisance factors. We show that simple adaptive thresholding improves
Hessian-Affine, DoG, MSER (and possibly other) detectors and allows to use them
on infrared and low contrast images.
A novel matching algorithm for addressing the WxBS problem has been
introduced. We have shown experimentally that the WxBS-M matcher dominantes the
state-of-the-art methods both on both the new and existing datasets.Comment: Descriptor and detector evaluation expande
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