Categorical Ontology of Complex Systems, Meta-Systems and Theory of Levels: The Emergence of Life, Human Consciousness and Society

Single cell interactomics in simpler organisms, as well as somatic cell interactomics in multicellular organisms, involve biomolecular interactions in complex signalling pathways that were recently represented in modular terms by quantum automata with ‘reversible behavior’ representing normal cell cycling and division. Other implications of such quantum automata, modular modeling of signaling pathways and cell differentiation during development are in the fields of neural plasticity and brain development leading to quantum-weave dynamic patterns and specific molecular processes underlying extensive memory, learning, anticipation mechanisms and the emergence of human consciousness during the early brain development in children. Cell interactomics is here represented for the first time as a mixture of ‘classical’ states that determine molecular dynamics subject to Boltzmann statistics and ‘steady-state’, metabolic (multi-stable) manifolds, together with ‘configuration’ spaces of metastable quantum states emerging from complex quantum dynamics of interacting networks of biomolecules, such as proteins and nucleic acids that are now collectively defined as quantum interactomics. On the other hand, the time dependent evolution over several generations of cancer cells --that are generally known to undergo frequent and extensive genetic mutations and, indeed, suffer genomic transformations at the chromosome level (such as extensive chromosomal aberrations found in many colon cancers)-- cannot be correctly represented in the ‘standard’ terms of quantum automaton modules, as the normal somatic cells can. This significant difference at the cancer cell genomic level is therefore reflected in major changes in cancer cell interactomics often from one cancer cell ‘cycle’ to the next, and thus it requires substantial changes in the modeling strategies, mathematical tools and experimental designs aimed at understanding cancer mechanisms. Novel solutions to this important problem in carcinogenesis are proposed and experimental validation procedures are suggested. From a medical research and clinical standpoint, this approach has important consequences for addressing and preventing the development of cancer resistance to medical therapy in ongoing clinical trials involving stage III cancer patients, as well as improving the designs of future clinical trials for cancer treatments.\ud \ud \ud KEYWORDS: Emergence of Life and Human Consciousness;\ud Proteomics; Artificial Intelligence; Complex Systems Dynamics; Quantum Automata models and Quantum Interactomics; quantum-weave dynamic patterns underlying human consciousness; specific molecular processes underlying extensive memory, learning, anticipation mechanisms and human consciousness; emergence of human consciousness during the early brain development in children; Cancer cell ‘cycling’; interacting networks of proteins and nucleic acids; genetic mutations and chromosomal aberrations in cancers, such as colon cancer; development of cancer resistance to therapy; ongoing clinical trials involving stage III cancer patients’ possible improvements of the designs for future clinical trials and cancer treatments. \ud \u

Quantum Systems as results of Geometric Evolutions

In the framework of deterministic finslerian models, a mechanism producing dissipative dynamics at the Planck scale is introduced. It is based on a geometric evolution from Finsler to Riemann structures defined in ${\bf TM}$. Quantum states are generated and interpreted as equivalence classes, composed by the configurations that evolve through an internal dynamics, to the same final state. The existence of an hermitian scalar product in an associated linear space is discussed and related with the quantum pre-Hilbert space. This hermitian product emerges from geometric and statistical considerations. Our scheme recovers the main ingredients of the usual Quantum Mechanics. Several testable consequences of our scheme are discussed and compared with usual Quantum Mechanics. A tentative solution of the cosmological constant problem is proposed, as well as a mechanism for the absence of quantum interferences at classical scales.Comment: paper withdraw

A multidimensionally consistent version of Hirota's discrete KdV equation

A multidimensionally consistent generalisation of Hirota's discrete KdV equation is proposed, it is a quad equation defined by a polynomial that is quadratic in each variable. Soliton solutions and interpretation of the model as superposition principle are given. It is discussed how an important property of the defining polynomial, a factorisation of discriminants, appears also in the few other known discrete integrable multi-quadratic models.Comment: 11 pages, 2 figure

Homogeneous Loop Quantum Cosmology

Loop quantum cosmological methods are extended to homogeneous models in diagonalized form. It is shown that the diagonalization leads to a simplification of the volume operator such that its spectrum can be determined explicitly. This allows the calculation of composite operators, most importantly the Hamiltonian constraint. As an application the dynamics of the Bianchi I model is studied and it is shown that its loop quantization is free of singularities.Comment: 25 pages, 3 figure